Differential regulation of glucocorticoid receptor messenger RNA (GR-mRNA) by maternal deprivation in immature rat hypothalamus and limbic regions
Maternal deprivation (MDep) of neonatal rats significantly influences the hypothalamic–pituitary–adrenal (HPA) axis. This study hypothesized that GR-mRNA modulation constituted an early, critical mechanism for the acute effects of MDep on neuroendocrine stress-responses. GR-mRNA hybridization signal...
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| Veröffentlicht in: | Brain research. Developmental brain research 1999-05, Vol.114 (2), p.265-268 |
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| container_title | Brain research. Developmental brain research |
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| creator | Avishai-Eliner, Sarit Hatalski, Carolyn G Tabachnik, Elvan Eghbal-Ahmadi, Mariam Baram, Tallie Z |
| description | Maternal deprivation (MDep) of neonatal rats significantly influences the hypothalamic–pituitary–adrenal (HPA) axis. This study hypothesized that GR-mRNA modulation constituted an early, critical mechanism for the acute effects of MDep on neuroendocrine stress-responses. GR-mRNA hybridization signal in hippocampal CA1, hypothalamic paraventricular nucleus (PVN) and frontal cortex was significantly reduced immediately following 24 h MDep. In amygdala, cingulate cortex, PVN and CA1, apparent gender-dependent MDep effects on GR-mRNA expression were observed, without significant differences in absolute levels. Thus, rapid, region-specific MDep effects on GR-mRNA expression in HPA-regulating areas are shown, consistent with involvement of GR-expression in mechanisms of MDep influence on HPA tone. |
| doi_str_mv | 10.1016/S0165-3806(99)00031-0 |
| format | Article |
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This study hypothesized that GR-mRNA modulation constituted an early, critical mechanism for the acute effects of MDep on neuroendocrine stress-responses. GR-mRNA hybridization signal in hippocampal CA1, hypothalamic paraventricular nucleus (PVN) and frontal cortex was significantly reduced immediately following 24 h MDep. In amygdala, cingulate cortex, PVN and CA1, apparent gender-dependent MDep effects on GR-mRNA expression were observed, without significant differences in absolute levels. Thus, rapid, region-specific MDep effects on GR-mRNA expression in HPA-regulating areas are shown, consistent with involvement of GR-expression in mechanisms of MDep influence on HPA tone.</description><identifier>ISSN: 0165-3806</identifier><identifier>DOI: 10.1016/S0165-3806(99)00031-0</identifier><identifier>PMID: 10320766</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject><![CDATA[Aging - physiology ; Amygdala - growth & development ; Amygdala - metabolism ; Amygdala central nucleus ; Animals ; Cerebral Cortex - growth & development ; Cerebral Cortex - metabolism ; Female ; Gene Expression Regulation, Developmental ; Glucocorticoid receptor messenger RNA ; Hippocampus ; Hippocampus - growth & development ; Hippocampus - metabolism ; Hypothalamic paraventricular nucleus ; Hypothalamus - growth & development ; Hypothalamus - metabolism ; Limbic System - growth & development ; Limbic System - metabolism ; Male ; Maternal Deprivation ; Paraventricular Hypothalamic Nucleus - growth & development ; Paraventricular Hypothalamic Nucleus - metabolism ; Rat ; Rats ; Rats, Sprague-Dawley ; RNA, Messenger - genetics ; Sex Characteristics ; Stress ; Transcription, Genetic]]></subject><ispartof>Brain research. Developmental brain research, 1999-05, Vol.114 (2), p.265-268</ispartof><rights>1999 Elsevier Science B.V.</rights><rights>Copyright 1999 Elsevier Science B.V.</rights><rights>1999 Elsevier Science B.V. All rights reserved. 1999</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c494t-42adf33c5094f4a8c1db8249ac0aa9772ff51598c790d984780d86d83a0f78603</citedby><cites>FETCH-LOGICAL-c494t-42adf33c5094f4a8c1db8249ac0aa9772ff51598c790d984780d86d83a0f78603</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10320766$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Avishai-Eliner, Sarit</creatorcontrib><creatorcontrib>Hatalski, Carolyn G</creatorcontrib><creatorcontrib>Tabachnik, Elvan</creatorcontrib><creatorcontrib>Eghbal-Ahmadi, Mariam</creatorcontrib><creatorcontrib>Baram, Tallie Z</creatorcontrib><title>Differential regulation of glucocorticoid receptor messenger RNA (GR-mRNA) by maternal deprivation in immature rat hypothalamus and limbic regions</title><title>Brain research. Developmental brain research</title><addtitle>Brain Res Dev Brain Res</addtitle><description>Maternal deprivation (MDep) of neonatal rats significantly influences the hypothalamic–pituitary–adrenal (HPA) axis. This study hypothesized that GR-mRNA modulation constituted an early, critical mechanism for the acute effects of MDep on neuroendocrine stress-responses. GR-mRNA hybridization signal in hippocampal CA1, hypothalamic paraventricular nucleus (PVN) and frontal cortex was significantly reduced immediately following 24 h MDep. In amygdala, cingulate cortex, PVN and CA1, apparent gender-dependent MDep effects on GR-mRNA expression were observed, without significant differences in absolute levels. Thus, rapid, region-specific MDep effects on GR-mRNA expression in HPA-regulating areas are shown, consistent with involvement of GR-expression in mechanisms of MDep influence on HPA tone.</description><subject>Aging - physiology</subject><subject>Amygdala - growth & development</subject><subject>Amygdala - metabolism</subject><subject>Amygdala central nucleus</subject><subject>Animals</subject><subject>Cerebral Cortex - growth & development</subject><subject>Cerebral Cortex - metabolism</subject><subject>Female</subject><subject>Gene Expression Regulation, Developmental</subject><subject>Glucocorticoid receptor messenger RNA</subject><subject>Hippocampus</subject><subject>Hippocampus - growth & development</subject><subject>Hippocampus - metabolism</subject><subject>Hypothalamic paraventricular nucleus</subject><subject>Hypothalamus - growth & development</subject><subject>Hypothalamus - metabolism</subject><subject>Limbic System - growth & development</subject><subject>Limbic System - metabolism</subject><subject>Male</subject><subject>Maternal Deprivation</subject><subject>Paraventricular Hypothalamic Nucleus - growth & development</subject><subject>Paraventricular Hypothalamic Nucleus - metabolism</subject><subject>Rat</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>RNA, Messenger - genetics</subject><subject>Sex Characteristics</subject><subject>Stress</subject><subject>Transcription, Genetic</subject><issn>0165-3806</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFUV1vFCEU5UFja_UnaHgy7cMoDAwDL5qmatuk0aTqM2HhsouZGVZgNtm_4S-W7TRNfWpCLuSew7kfB6E3lLynhIoPP2roGiaJOFXqjBDCaEOeoeOH9BF6mfPvClAm6Qt0RAlrSS_EMfr7OXgPCaYSzIATrOfBlBAnHD1eD7ONNqYSbAyugha2JSY8Qs4wrSHh22_n-PTythnr4wyv9ng0BdJUlRxsU9gtUqGesSJzApxMwZv9NpaNGcw4Z2wmh4cwroI9VK_0_Ao992bI8Pr-PkG_vn75eXHV3Hy_vL44v2ksV7w0vDXOM2Y7orjnRlrqVrLlylhijOr71vuOdkraXhGnJO8lcVI4yQzxvRSEnaCPi-52Xo3gbN1BMoOufY8m7XU0Qf-PTGGj13GnGWWKi7YKvLsXSPHPDLnoMWQLw2AmiHPWQvW8J4I-SaR9qyjnohK7hWhTzDmBf-iGEn2wWt9ZrQ-eaqX0ndX6MMrbx6M8-rX4XAmfFgLUhe4CJJ1tgMmCC9XWol0MT5T4B8Gpvi0</recordid><startdate>19990514</startdate><enddate>19990514</enddate><creator>Avishai-Eliner, Sarit</creator><creator>Hatalski, Carolyn G</creator><creator>Tabachnik, Elvan</creator><creator>Eghbal-Ahmadi, Mariam</creator><creator>Baram, Tallie Z</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19990514</creationdate><title>Differential regulation of glucocorticoid receptor messenger RNA (GR-mRNA) by maternal deprivation in immature rat hypothalamus and limbic regions</title><author>Avishai-Eliner, Sarit ; Hatalski, Carolyn G ; Tabachnik, Elvan ; Eghbal-Ahmadi, Mariam ; Baram, Tallie Z</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c494t-42adf33c5094f4a8c1db8249ac0aa9772ff51598c790d984780d86d83a0f78603</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Aging - physiology</topic><topic>Amygdala - growth & development</topic><topic>Amygdala - metabolism</topic><topic>Amygdala central nucleus</topic><topic>Animals</topic><topic>Cerebral Cortex - growth & development</topic><topic>Cerebral Cortex - metabolism</topic><topic>Female</topic><topic>Gene Expression Regulation, Developmental</topic><topic>Glucocorticoid receptor messenger RNA</topic><topic>Hippocampus</topic><topic>Hippocampus - growth & development</topic><topic>Hippocampus - metabolism</topic><topic>Hypothalamic paraventricular nucleus</topic><topic>Hypothalamus - growth & development</topic><topic>Hypothalamus - metabolism</topic><topic>Limbic System - growth & development</topic><topic>Limbic System - metabolism</topic><topic>Male</topic><topic>Maternal Deprivation</topic><topic>Paraventricular Hypothalamic Nucleus - growth & development</topic><topic>Paraventricular Hypothalamic Nucleus - metabolism</topic><topic>Rat</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>RNA, Messenger - genetics</topic><topic>Sex Characteristics</topic><topic>Stress</topic><topic>Transcription, Genetic</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Avishai-Eliner, Sarit</creatorcontrib><creatorcontrib>Hatalski, Carolyn G</creatorcontrib><creatorcontrib>Tabachnik, Elvan</creatorcontrib><creatorcontrib>Eghbal-Ahmadi, Mariam</creatorcontrib><creatorcontrib>Baram, Tallie Z</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Brain research. Developmental brain research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Avishai-Eliner, Sarit</au><au>Hatalski, Carolyn G</au><au>Tabachnik, Elvan</au><au>Eghbal-Ahmadi, Mariam</au><au>Baram, Tallie Z</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Differential regulation of glucocorticoid receptor messenger RNA (GR-mRNA) by maternal deprivation in immature rat hypothalamus and limbic regions</atitle><jtitle>Brain research. Developmental brain research</jtitle><addtitle>Brain Res Dev Brain Res</addtitle><date>1999-05-14</date><risdate>1999</risdate><volume>114</volume><issue>2</issue><spage>265</spage><epage>268</epage><pages>265-268</pages><issn>0165-3806</issn><abstract>Maternal deprivation (MDep) of neonatal rats significantly influences the hypothalamic–pituitary–adrenal (HPA) axis. 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| subjects | Aging - physiology Amygdala - growth & development Amygdala - metabolism Amygdala central nucleus Animals Cerebral Cortex - growth & development Cerebral Cortex - metabolism Female Gene Expression Regulation, Developmental Glucocorticoid receptor messenger RNA Hippocampus Hippocampus - growth & development Hippocampus - metabolism Hypothalamic paraventricular nucleus Hypothalamus - growth & development Hypothalamus - metabolism Limbic System - growth & development Limbic System - metabolism Male Maternal Deprivation Paraventricular Hypothalamic Nucleus - growth & development Paraventricular Hypothalamic Nucleus - metabolism Rat Rats Rats, Sprague-Dawley RNA, Messenger - genetics Sex Characteristics Stress Transcription, Genetic |
| title | Differential regulation of glucocorticoid receptor messenger RNA (GR-mRNA) by maternal deprivation in immature rat hypothalamus and limbic regions |
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