Structural and Functional Analyses Reveal That Staphylococcus aureus Antibiotic Resistance Factor HmrA Is a Zinc-dependent Endopeptidase

HmrA is an antibiotic resistance factor of methicillin-resistant Staphylococcus aureus. Molecular analysis of this protein revealed that it is not a muramidase or β-lactamase but a nonspecific double-zinc endopeptidase consisting of a catalytic domain and an inserted oligomerization domain, which pr...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The Journal of biological chemistry 2011-07, Vol.286 (29), p.25697-25709
Hauptverfasser:	Botelho, Tiago O., Guevara, Tibisay, Marrero, Aniebrys, Arêde, Pedro, Fluxà, Viviana S., Reymond, Jean-Louis, Oliveira, Duarte C., Gomis-Rüth, F. Xavier
Format:	Artikel
Sprache:	eng
Schlagworte:	ADAM ADAMTS Anti-Bacterial Agents - pharmacology Antibiotics Bacterial Proteins - antagonists & inhibitors Bacterial Proteins - chemistry Bacterial Proteins - metabolism Biophysical Phenomena Catalytic Domain Drug Design Drug Resistance, Bacterial Endopeptidases - chemistry Endopeptidases - metabolism Matrix Metalloproteinase (MMP) Metalloprotease Models, Molecular Movement Peptidases Protease Inhibitors - pharmacology Protein Multimerization Protein Structure and Folding Protein Structure, Quaternary Staphylococcus aureus - drug effects Staphylococcus aureus - enzymology Zinc - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!