Cassia auriculata : Aspects of Safety Pharmacology and Drug Interaction
Safety pharmacology studies help in identifying preclinical adverse drug reactions. We carried out routine safety pharmacology with focus on cardiovascular variables and pharmacokinetic herb-drug interaction studies on rats fed with standardized traditional hydro-alcoholic extract and technology-bas...
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| Veröffentlicht in: | Evidence-based complementary and alternative medicine 2011-01, Vol.2011 (2011), p.1-8 |
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| container_title | Evidence-based complementary and alternative medicine |
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| creator | Halade, Ganesh Puranik, Amrutesh S. Kumar, Sandeep Mogre, Ranjan Apte, Kishori Vaidya, Ashok D. B. Patwardhan, Bhushan |
| description | Safety pharmacology studies help in identifying preclinical adverse drug reactions. We carried out routine safety pharmacology with focus on cardiovascular variables and pharmacokinetic herb-drug interaction studies on rats fed with standardized traditional hydro-alcoholic extract and technology-based supercritical extract of Cassia auriculata for 12 weeks. Our studies indicate that both these extracts are pharmacologically safe and did not show any significant adverse reactions at the tested doses. The traditional hydro-alcoholic extract did not show any significant effect on pharmacokinetics; however, the technology-based supercritical extract caused a significant reduction in absorption of metformin. Our results indicate the need to include pharmacokinetic herb-drug interaction studies as evidence for safety especially for technology-based extracts. |
| doi_str_mv | 10.1093/ecam/nep237 |
| format | Article |
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B. ; Patwardhan, Bhushan</creator><creatorcontrib>Halade, Ganesh ; Puranik, Amrutesh S. ; Kumar, Sandeep ; Mogre, Ranjan ; Apte, Kishori ; Vaidya, Ashok D. B. ; Patwardhan, Bhushan</creatorcontrib><description>Safety pharmacology studies help in identifying preclinical adverse drug reactions. We carried out routine safety pharmacology with focus on cardiovascular variables and pharmacokinetic herb-drug interaction studies on rats fed with standardized traditional hydro-alcoholic extract and technology-based supercritical extract of Cassia auriculata for 12 weeks. Our studies indicate that both these extracts are pharmacologically safe and did not show any significant adverse reactions at the tested doses. The traditional hydro-alcoholic extract did not show any significant effect on pharmacokinetics; however, the technology-based supercritical extract caused a significant reduction in absorption of metformin. Our results indicate the need to include pharmacokinetic herb-drug interaction studies as evidence for safety especially for technology-based extracts.</description><identifier>ISSN: 1741-427X</identifier><identifier>EISSN: 1741-4288</identifier><identifier>DOI: 10.1093/ecam/nep237</identifier><identifier>PMID: 21785642</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Puplishing Corporation</publisher><subject>Ayurvedic medicine ; Cassia auriculata ; Chromatography ; Chronic illnesses ; Diabetes ; Drug interaction ; Drug interactions ; Drugs ; Glucose ; Herbal medicine ; Herbs ; Homocysteine ; Metformin ; Original ; Oxidative stress ; Pharmacokinetics ; Pharmacology ; Polyphenols ; R&D ; Research & development ; Safety ; Side effects ; Technology</subject><ispartof>Evidence-based complementary and alternative medicine, 2011-01, Vol.2011 (2011), p.1-8</ispartof><rights>Copyright © 2011 Amrutesh S. Puranik et al.</rights><rights>Copyright © 2011 Amrutesh S. Puranik et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. https://creativecommons.org/licenses/by/4.0</rights><rights>Copyright © 2011 Amrutesh S. 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B.</creatorcontrib><creatorcontrib>Patwardhan, Bhushan</creatorcontrib><title>Cassia auriculata : Aspects of Safety Pharmacology and Drug Interaction</title><title>Evidence-based complementary and alternative medicine</title><addtitle>Evid Based Complement Alternat Med</addtitle><description>Safety pharmacology studies help in identifying preclinical adverse drug reactions. We carried out routine safety pharmacology with focus on cardiovascular variables and pharmacokinetic herb-drug interaction studies on rats fed with standardized traditional hydro-alcoholic extract and technology-based supercritical extract of Cassia auriculata for 12 weeks. Our studies indicate that both these extracts are pharmacologically safe and did not show any significant adverse reactions at the tested doses. The traditional hydro-alcoholic extract did not show any significant effect on pharmacokinetics; however, the technology-based supercritical extract caused a significant reduction in absorption of metformin. Our results indicate the need to include pharmacokinetic herb-drug interaction studies as evidence for safety especially for technology-based extracts.</description><subject>Ayurvedic medicine</subject><subject>Cassia auriculata</subject><subject>Chromatography</subject><subject>Chronic illnesses</subject><subject>Diabetes</subject><subject>Drug interaction</subject><subject>Drug interactions</subject><subject>Drugs</subject><subject>Glucose</subject><subject>Herbal medicine</subject><subject>Herbs</subject><subject>Homocysteine</subject><subject>Metformin</subject><subject>Original</subject><subject>Oxidative stress</subject><subject>Pharmacokinetics</subject><subject>Pharmacology</subject><subject>Polyphenols</subject><subject>R&D</subject><subject>Research & development</subject><subject>Safety</subject><subject>Side effects</subject><subject>Technology</subject><issn>1741-427X</issn><issn>1741-4288</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>RHX</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqFkEFLAzEQRoMotlZPnpWAN6U22Ww2WQ9CqVoLBQUVvIVpNttuaTc12VX6703ZWvTkaQbm8c3MQ-iUkmtKUtYzGpa90qwiJvZQm4qYduNIyv1dL95b6Mj7OSFRKoQ4RK2ICsmTOGqj4QC8LwBD7QpdL6ACfIP7fmV05bHN8Qvkplrj5xm4JWi7sNM1hjLDd66e4lFZGQe6Kmx5jA5yWHhzsq0d9PZw_zp47I6fhqNBf9zVccKrrs4YzRjTXIPQwkCWaGqknmQkTbKc8ciEMuFpxCWRoWMTCQkJ7-S5TDgVrINum9xVPVmaTJuycrBQK1cswa2VhUL9nZTFTE3tp2KUCZEmIeBiG-DsR218pea2dmW4WUUkIZLEIkjtoKuG0s5670y-20CJ2lhXG-uqsR7o899H7dgfzQG4bIBZUWbwVfyTdtbAJiAmhx3MiRCcsG-jxphk</recordid><startdate>20110101</startdate><enddate>20110101</enddate><creator>Halade, Ganesh</creator><creator>Puranik, Amrutesh S.</creator><creator>Kumar, Sandeep</creator><creator>Mogre, Ranjan</creator><creator>Apte, Kishori</creator><creator>Vaidya, Ashok D. 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B. ; Patwardhan, Bhushan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c465t-cd31d33c5ca7c7ead6c1e8cbd096df352e6dfb5925808dfb3b8a60428ff865173</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Ayurvedic medicine</topic><topic>Cassia auriculata</topic><topic>Chromatography</topic><topic>Chronic illnesses</topic><topic>Diabetes</topic><topic>Drug interaction</topic><topic>Drug interactions</topic><topic>Drugs</topic><topic>Glucose</topic><topic>Herbal medicine</topic><topic>Herbs</topic><topic>Homocysteine</topic><topic>Metformin</topic><topic>Original</topic><topic>Oxidative stress</topic><topic>Pharmacokinetics</topic><topic>Pharmacology</topic><topic>Polyphenols</topic><topic>R&D</topic><topic>Research & development</topic><topic>Safety</topic><topic>Side effects</topic><topic>Technology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Halade, Ganesh</creatorcontrib><creatorcontrib>Puranik, Amrutesh S.</creatorcontrib><creatorcontrib>Kumar, Sandeep</creatorcontrib><creatorcontrib>Mogre, Ranjan</creatorcontrib><creatorcontrib>Apte, Kishori</creatorcontrib><creatorcontrib>Vaidya, Ashok D. 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B.</au><au>Patwardhan, Bhushan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cassia auriculata : Aspects of Safety Pharmacology and Drug Interaction</atitle><jtitle>Evidence-based complementary and alternative medicine</jtitle><addtitle>Evid Based Complement Alternat Med</addtitle><date>2011-01-01</date><risdate>2011</risdate><volume>2011</volume><issue>2011</issue><spage>1</spage><epage>8</epage><pages>1-8</pages><issn>1741-427X</issn><eissn>1741-4288</eissn><abstract>Safety pharmacology studies help in identifying preclinical adverse drug reactions. We carried out routine safety pharmacology with focus on cardiovascular variables and pharmacokinetic herb-drug interaction studies on rats fed with standardized traditional hydro-alcoholic extract and technology-based supercritical extract of Cassia auriculata for 12 weeks. 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| source | PubMed Central Open Access; Wiley Online Library Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Ayurvedic medicine Cassia auriculata Chromatography Chronic illnesses Diabetes Drug interaction Drug interactions Drugs Glucose Herbal medicine Herbs Homocysteine Metformin Original Oxidative stress Pharmacokinetics Pharmacology Polyphenols R&D Research & development Safety Side effects Technology |
| title | Cassia auriculata : Aspects of Safety Pharmacology and Drug Interaction |
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