Reactive oxygen species (ROS) from NADPH and xanthine oxidase modulate the cutaneous local heating response in healthy humans

Local cutaneous heating produces vasodilation that is largely nitric oxide (NO) dependent. We showed that angiotensin II (ANG II) attenuates this by an ANG II receptor, type 1 (AT1R)-dependent mechanism that is reversible with the antioxidant ascorbate, indicating oxidative stress. Reactive oxygen s...

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Veröffentlicht in:	Journal of applied physiology (1985) 2011-07, Vol.111 (1), p.20-26
Hauptverfasser:	MEDOW, Marvin S, BAMJI, Natasha, CLARKE, Debbie, OCON, Anthony J, STEWART, Julian M
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetophenones - administration & dosage Adult Allopurinol - administration & dosage Analysis of Variance Angiotensin II - administration & dosage Angiotensin II - metabolism Antioxidants - administration & dosage Azoles - administration & dosage Biological and medical sciences Blood Vessels - enzymology Chemical compounds Cyclic N-Oxides - administration & dosage Cytokines Enzyme Inhibitors - administration & dosage Female Fundamental and applied biological sciences. Psychology Heat Hot Temperature Humans Laser-Doppler Flowmetry Leg Male Microdialysis NADPH Oxidases - antagonists & inhibitors NADPH Oxidases - metabolism Organoselenium Compounds - administration & dosage Physiology Reactive Oxygen Species - metabolism Regional Blood Flow Skin Skin - blood supply Skin Temperature Spin Labels Time Factors Vasodilation - drug effects Xanthine Oxidase - antagonists & inhibitors Xanthine Oxidase - metabolism
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