Effects of Inflammatory Factors on Mesenchymal Stem Cells and Their Role in the Promotion of Tumor Angiogenesis in Colon Cancer

Mesenchymal stem cells (MSCs), which are modulated by cytokines present in the tumor microenvironment, play an important role in tumor progression. It is well documented that inflammation is an important part of the tumor microenvironment, so we investigated whether stimulation of MSCs by inflammato...

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Veröffentlicht in:	The Journal of biological chemistry 2011-07, Vol.286 (28), p.25007-25015
Hauptverfasser:	Liu, Yan, Han, Zhi-peng, Zhang, Shan-shan, Jing, Ying-ying, Bu, Xin-xin, Wang, Chen-yang, Sun, Kai, Jiang, Guo-cheng, Zhao, Xue, Li, Rong, Gao, Lu, Zhao, Qiu-dong, Wu, Meng-chao, Wei, Li-xin
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antiviral Agents - metabolism Antiviral Agents - pharmacology Cell Biology Cell Line, Tumor Chick Embryo Chorioallantoic Membrane - metabolism Chorioallantoic Membrane - pathology Colon Cancer Colonic Neoplasms - metabolism Colonic Neoplasms - pathology Culture Media, Conditioned - pharmacology Hypoxia-Inducible Factor 1, alpha Subunit - metabolism Inflammation Inflammation Mediators - metabolism Inflammation Mediators - pharmacology Interferon-gamma - metabolism Interferon-gamma - pharmacology Male Mesenchymal Stem Cells - metabolism Mesenchymal Stem Cells - pathology Mice Mice, Inbred BALB C MicroRNA Neovascularization, Pathologic - metabolism Neovascularization, Pathologic - pathology Stem Cell Tumor Tumor Microenvironment Tumor Necrosis Factor-alpha - metabolism Vascular Endothelial Growth Factor A - metabolism
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