Electroacupuncture at the Zusanli (ST-36) Acupoint Induces a Hypoglycemic Effect by Stimulating the Cholinergic Nerve in a Rat Model of Streptozotocine-Induced Insulin-Dependent Diabetes Mellitus
Animal studies have shown that electroacupuncture (EA) at Zusanli (ST-36) and Zhongwan (CV-12) acupoints reduces plasma glucose concentrations in rats with type II diabetes. However, whether EA reduces plasma glucose levels in type I diabetes is still unknown. In this study, we explore the various n...
Gespeichert in:
| Veröffentlicht in: | Evidence-based complementary and alternative medicine 2011-01, Vol.2011 (2011), p.1-6 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 6 |
|---|---|
| container_issue | 2011 |
| container_start_page | 1 |
| container_title | Evidence-based complementary and alternative medicine |
| container_volume | 2011 |
| creator | Lee, Yu-Chen Li, Te-Mao Tzeng, Chung-Yuh Chen, Ying-I Ho, Wai-Jane Lin, Jaung-Geng Chang, Shih-Liang |
| description | Animal studies have shown that electroacupuncture (EA) at Zusanli (ST-36) and Zhongwan (CV-12) acupoints reduces plasma glucose concentrations in rats with type II diabetes. However, whether EA reduces plasma glucose levels in type I diabetes is still unknown. In this study, we explore the various non-insulin-dependent pathways involved in EA-induced lowering of plasma glucose. Streptozotocin (STZ) (60 mg kg−1, i.v.) was administered via the femoral vein to induce insulin-dependent diabetes in non-adrenalectomized and in adrenalectomomized rats. EA (15 Hz) was applied for 30 min to bilateral ST-36 acupoints after administration of Atropine (0.1 mg kg−1 i.p.), Eserine (0.01 mg kg−1 i.p.), or Hemicholinium-3 (5 μg kg−1 i.p.) in non-adrenalectomized rats. Rats administered acetylcholine (0.01 mg kg−1 i.v.) did not undergo EA. Adrenalectomized rats underwent EA at bilateral ST-36 acupoints without further treatment. Blood samples were drawn from all rats before and after EA to measure changes in plasma glucose levels. Expression of insulin signaling proteins (IRS1, AKT2) in atropine-exposed rats before and after EA was measured by western blot. Atropine and hemicholinium-3 completely blocked the plasma glucose lowering effects of EA, whereas eserine led to a significant hypoglycemic response. In addition, plasma glucose levels after administration of acetylcholine were significantly lower than the fasting glucose levels. In STZ-adrenalectomized rats, EA did not induce a hypoglycemic response. EA stimulated the expression of IRS1 and AKT2 and atropine treatment blocked the EA-induced expression of those insulin signaling proteins. Taken together, EA at the ST-36 acupoint reduces plasma glucose concentrations by stimulating the cholinergic nerves. |
| doi_str_mv | 10.1093/ecam/neq068 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3136799</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2060804830</sourcerecordid><originalsourceid>FETCH-LOGICAL-c465t-dd00157e9ee406d7d9560cc1d2fa93ac68cc7b18263e76daf32b368ce6219f873</originalsourceid><addsrcrecordid>eNqFkk9rFDEYxgdRbK2ePCsBD1ZlbDKZTTIXoWxXW2gVbAXxMmSTd3ZTZpJp_rSsX88vZurURb14Skh-7_M8CU9RPCX4LcENPQAlhwMLV5iJe8Uu4TUp60qI-9s9_7pTPArhEuOq4Zw_LHYqwpuGCbZb_Fj0oKJ3UqUxWRWTByQjimtA31KQtjdo__yipOwVOsyIMzaiE6uTgoAkOt6MbtVvFAxGoUXXZSm03KDzaIbUy2js6pfSfO16Y8GvMvUR_DUgY_P052x05jT0yHV5xsMY3XcXncpsOZnobBZSHi6PYASrIdsfGbmEmP3PoO9NTOFx8aCTfYAnd-te8eX94mJ-XJ5--nAyPzwtVc1msdQaYzLj0ADUmGmumxnDShFddbKhUjGhFF8SUTEKnGnZ0WpJ8yGwijSd4HSveDfpjmk5gFY5jJd9O3ozSL9pnTTt3zfWrNuVu24poSx_eBZ4eSfg3VWCENvBBJVfIS24FFohMKGcMpLJF_-Qly55m1_XVphhgWtBcabeTJTyLgQP3TYLwe1tN9rbbrRTNzL9_M_4W_Z3GTLwegLWxmp5Y_6j9myCISPQyS1cC5Ej0p8Hp9MJ</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2060804830</pqid></control><display><type>article</type><title>Electroacupuncture at the Zusanli (ST-36) Acupoint Induces a Hypoglycemic Effect by Stimulating the Cholinergic Nerve in a Rat Model of Streptozotocine-Induced Insulin-Dependent Diabetes Mellitus</title><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central Open Access</source><source>Wiley Online Library (Open Access Collection)</source><source>PubMed Central</source><source>Alma/SFX Local Collection</source><creator>Lee, Yu-Chen ; Li, Te-Mao ; Tzeng, Chung-Yuh ; Chen, Ying-I ; Ho, Wai-Jane ; Lin, Jaung-Geng ; Chang, Shih-Liang</creator><creatorcontrib>Lee, Yu-Chen ; Li, Te-Mao ; Tzeng, Chung-Yuh ; Chen, Ying-I ; Ho, Wai-Jane ; Lin, Jaung-Geng ; Chang, Shih-Liang</creatorcontrib><description>Animal studies have shown that electroacupuncture (EA) at Zusanli (ST-36) and Zhongwan (CV-12) acupoints reduces plasma glucose concentrations in rats with type II diabetes. However, whether EA reduces plasma glucose levels in type I diabetes is still unknown. In this study, we explore the various non-insulin-dependent pathways involved in EA-induced lowering of plasma glucose. Streptozotocin (STZ) (60 mg kg−1, i.v.) was administered via the femoral vein to induce insulin-dependent diabetes in non-adrenalectomized and in adrenalectomomized rats. EA (15 Hz) was applied for 30 min to bilateral ST-36 acupoints after administration of Atropine (0.1 mg kg−1 i.p.), Eserine (0.01 mg kg−1 i.p.), or Hemicholinium-3 (5 μg kg−1 i.p.) in non-adrenalectomized rats. Rats administered acetylcholine (0.01 mg kg−1 i.v.) did not undergo EA. Adrenalectomized rats underwent EA at bilateral ST-36 acupoints without further treatment. Blood samples were drawn from all rats before and after EA to measure changes in plasma glucose levels. Expression of insulin signaling proteins (IRS1, AKT2) in atropine-exposed rats before and after EA was measured by western blot. Atropine and hemicholinium-3 completely blocked the plasma glucose lowering effects of EA, whereas eserine led to a significant hypoglycemic response. In addition, plasma glucose levels after administration of acetylcholine were significantly lower than the fasting glucose levels. In STZ-adrenalectomized rats, EA did not induce a hypoglycemic response. EA stimulated the expression of IRS1 and AKT2 and atropine treatment blocked the EA-induced expression of those insulin signaling proteins. Taken together, EA at the ST-36 acupoint reduces plasma glucose concentrations by stimulating the cholinergic nerves.</description><identifier>ISSN: 1741-427X</identifier><identifier>EISSN: 1741-4288</identifier><identifier>DOI: 10.1093/ecam/neq068</identifier><identifier>PMID: 21799686</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Puplishing Corporation</publisher><subject>Acetylcholine ; Acupuncture ; AKT2 protein ; Atropine ; Cholinergic nerves ; Diabetes mellitus ; Diabetes mellitus (insulin dependent) ; Diabetes mellitus (non-insulin dependent) ; Electroacupuncture ; Femur ; Glucose ; Hypoglycemia ; Insulin ; Insulin resistance ; Kinases ; Nerves ; Neurosciences ; Original ; Physostigmine ; Plasma ; Proteins ; Rats ; Rodents ; Streptozocin ; Tempering</subject><ispartof>Evidence-based complementary and alternative medicine, 2011-01, Vol.2011 (2011), p.1-6</ispartof><rights>Copyright © 2011 Yu-Chen Lee et al.</rights><rights>Copyright © 2011 Yu-Chen Lee et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. https://creativecommons.org/licenses/by/4.0</rights><rights>Copyright © 2011 Yu-Chen Lee et al. 2011</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c465t-dd00157e9ee406d7d9560cc1d2fa93ac68cc7b18263e76daf32b368ce6219f873</citedby><cites>FETCH-LOGICAL-c465t-dd00157e9ee406d7d9560cc1d2fa93ac68cc7b18263e76daf32b368ce6219f873</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3136799/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3136799/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,728,781,785,886,27929,27930,53796,53798</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21799686$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lee, Yu-Chen</creatorcontrib><creatorcontrib>Li, Te-Mao</creatorcontrib><creatorcontrib>Tzeng, Chung-Yuh</creatorcontrib><creatorcontrib>Chen, Ying-I</creatorcontrib><creatorcontrib>Ho, Wai-Jane</creatorcontrib><creatorcontrib>Lin, Jaung-Geng</creatorcontrib><creatorcontrib>Chang, Shih-Liang</creatorcontrib><title>Electroacupuncture at the Zusanli (ST-36) Acupoint Induces a Hypoglycemic Effect by Stimulating the Cholinergic Nerve in a Rat Model of Streptozotocine-Induced Insulin-Dependent Diabetes Mellitus</title><title>Evidence-based complementary and alternative medicine</title><addtitle>Evid Based Complement Alternat Med</addtitle><description>Animal studies have shown that electroacupuncture (EA) at Zusanli (ST-36) and Zhongwan (CV-12) acupoints reduces plasma glucose concentrations in rats with type II diabetes. However, whether EA reduces plasma glucose levels in type I diabetes is still unknown. In this study, we explore the various non-insulin-dependent pathways involved in EA-induced lowering of plasma glucose. Streptozotocin (STZ) (60 mg kg−1, i.v.) was administered via the femoral vein to induce insulin-dependent diabetes in non-adrenalectomized and in adrenalectomomized rats. EA (15 Hz) was applied for 30 min to bilateral ST-36 acupoints after administration of Atropine (0.1 mg kg−1 i.p.), Eserine (0.01 mg kg−1 i.p.), or Hemicholinium-3 (5 μg kg−1 i.p.) in non-adrenalectomized rats. Rats administered acetylcholine (0.01 mg kg−1 i.v.) did not undergo EA. Adrenalectomized rats underwent EA at bilateral ST-36 acupoints without further treatment. Blood samples were drawn from all rats before and after EA to measure changes in plasma glucose levels. Expression of insulin signaling proteins (IRS1, AKT2) in atropine-exposed rats before and after EA was measured by western blot. Atropine and hemicholinium-3 completely blocked the plasma glucose lowering effects of EA, whereas eserine led to a significant hypoglycemic response. In addition, plasma glucose levels after administration of acetylcholine were significantly lower than the fasting glucose levels. In STZ-adrenalectomized rats, EA did not induce a hypoglycemic response. EA stimulated the expression of IRS1 and AKT2 and atropine treatment blocked the EA-induced expression of those insulin signaling proteins. Taken together, EA at the ST-36 acupoint reduces plasma glucose concentrations by stimulating the cholinergic nerves.</description><subject>Acetylcholine</subject><subject>Acupuncture</subject><subject>AKT2 protein</subject><subject>Atropine</subject><subject>Cholinergic nerves</subject><subject>Diabetes mellitus</subject><subject>Diabetes mellitus (insulin dependent)</subject><subject>Diabetes mellitus (non-insulin dependent)</subject><subject>Electroacupuncture</subject><subject>Femur</subject><subject>Glucose</subject><subject>Hypoglycemia</subject><subject>Insulin</subject><subject>Insulin resistance</subject><subject>Kinases</subject><subject>Nerves</subject><subject>Neurosciences</subject><subject>Original</subject><subject>Physostigmine</subject><subject>Plasma</subject><subject>Proteins</subject><subject>Rats</subject><subject>Rodents</subject><subject>Streptozocin</subject><subject>Tempering</subject><issn>1741-427X</issn><issn>1741-4288</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>RHX</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqFkk9rFDEYxgdRbK2ePCsBD1ZlbDKZTTIXoWxXW2gVbAXxMmSTd3ZTZpJp_rSsX88vZurURb14Skh-7_M8CU9RPCX4LcENPQAlhwMLV5iJe8Uu4TUp60qI-9s9_7pTPArhEuOq4Zw_LHYqwpuGCbZb_Fj0oKJ3UqUxWRWTByQjimtA31KQtjdo__yipOwVOsyIMzaiE6uTgoAkOt6MbtVvFAxGoUXXZSm03KDzaIbUy2js6pfSfO16Y8GvMvUR_DUgY_P052x05jT0yHV5xsMY3XcXncpsOZnobBZSHi6PYASrIdsfGbmEmP3PoO9NTOFx8aCTfYAnd-te8eX94mJ-XJ5--nAyPzwtVc1msdQaYzLj0ADUmGmumxnDShFddbKhUjGhFF8SUTEKnGnZ0WpJ8yGwijSd4HSveDfpjmk5gFY5jJd9O3ozSL9pnTTt3zfWrNuVu24poSx_eBZ4eSfg3VWCENvBBJVfIS24FFohMKGcMpLJF_-Qly55m1_XVphhgWtBcabeTJTyLgQP3TYLwe1tN9rbbrRTNzL9_M_4W_Z3GTLwegLWxmp5Y_6j9myCISPQyS1cC5Ej0p8Hp9MJ</recordid><startdate>20110101</startdate><enddate>20110101</enddate><creator>Lee, Yu-Chen</creator><creator>Li, Te-Mao</creator><creator>Tzeng, Chung-Yuh</creator><creator>Chen, Ying-I</creator><creator>Ho, Wai-Jane</creator><creator>Lin, Jaung-Geng</creator><creator>Chang, Shih-Liang</creator><general>Hindawi Puplishing Corporation</general><general>Hindawi Publishing Corporation</general><general>Hindawi Limited</general><scope>ADJCN</scope><scope>AHFXO</scope><scope>RHU</scope><scope>RHW</scope><scope>RHX</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7T5</scope><scope>7TO</scope><scope>7X7</scope><scope>7XB</scope><scope>88G</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M2M</scope><scope>M2O</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20110101</creationdate><title>Electroacupuncture at the Zusanli (ST-36) Acupoint Induces a Hypoglycemic Effect by Stimulating the Cholinergic Nerve in a Rat Model of Streptozotocine-Induced Insulin-Dependent Diabetes Mellitus</title><author>Lee, Yu-Chen ; Li, Te-Mao ; Tzeng, Chung-Yuh ; Chen, Ying-I ; Ho, Wai-Jane ; Lin, Jaung-Geng ; Chang, Shih-Liang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c465t-dd00157e9ee406d7d9560cc1d2fa93ac68cc7b18263e76daf32b368ce6219f873</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Acetylcholine</topic><topic>Acupuncture</topic><topic>AKT2 protein</topic><topic>Atropine</topic><topic>Cholinergic nerves</topic><topic>Diabetes mellitus</topic><topic>Diabetes mellitus (insulin dependent)</topic><topic>Diabetes mellitus (non-insulin dependent)</topic><topic>Electroacupuncture</topic><topic>Femur</topic><topic>Glucose</topic><topic>Hypoglycemia</topic><topic>Insulin</topic><topic>Insulin resistance</topic><topic>Kinases</topic><topic>Nerves</topic><topic>Neurosciences</topic><topic>Original</topic><topic>Physostigmine</topic><topic>Plasma</topic><topic>Proteins</topic><topic>Rats</topic><topic>Rodents</topic><topic>Streptozocin</topic><topic>Tempering</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lee, Yu-Chen</creatorcontrib><creatorcontrib>Li, Te-Mao</creatorcontrib><creatorcontrib>Tzeng, Chung-Yuh</creatorcontrib><creatorcontrib>Chen, Ying-I</creatorcontrib><creatorcontrib>Ho, Wai-Jane</creatorcontrib><creatorcontrib>Lin, Jaung-Geng</creatorcontrib><creatorcontrib>Chang, Shih-Liang</creatorcontrib><collection>الدوريات العلمية والإحصائية - e-Marefa Academic and Statistical Periodicals</collection><collection>معرفة - المحتوى العربي الأكاديمي المتكامل - e-Marefa Academic Complete</collection><collection>Hindawi Publishing Complete</collection><collection>Hindawi Publishing Subscription Journals</collection><collection>Hindawi Publishing Open Access</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Immunology Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Psychology Database (Alumni)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Proquest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Psychology Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>Access via ProQuest (Open Access)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Evidence-based complementary and alternative medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lee, Yu-Chen</au><au>Li, Te-Mao</au><au>Tzeng, Chung-Yuh</au><au>Chen, Ying-I</au><au>Ho, Wai-Jane</au><au>Lin, Jaung-Geng</au><au>Chang, Shih-Liang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Electroacupuncture at the Zusanli (ST-36) Acupoint Induces a Hypoglycemic Effect by Stimulating the Cholinergic Nerve in a Rat Model of Streptozotocine-Induced Insulin-Dependent Diabetes Mellitus</atitle><jtitle>Evidence-based complementary and alternative medicine</jtitle><addtitle>Evid Based Complement Alternat Med</addtitle><date>2011-01-01</date><risdate>2011</risdate><volume>2011</volume><issue>2011</issue><spage>1</spage><epage>6</epage><pages>1-6</pages><issn>1741-427X</issn><eissn>1741-4288</eissn><abstract>Animal studies have shown that electroacupuncture (EA) at Zusanli (ST-36) and Zhongwan (CV-12) acupoints reduces plasma glucose concentrations in rats with type II diabetes. However, whether EA reduces plasma glucose levels in type I diabetes is still unknown. In this study, we explore the various non-insulin-dependent pathways involved in EA-induced lowering of plasma glucose. Streptozotocin (STZ) (60 mg kg−1, i.v.) was administered via the femoral vein to induce insulin-dependent diabetes in non-adrenalectomized and in adrenalectomomized rats. EA (15 Hz) was applied for 30 min to bilateral ST-36 acupoints after administration of Atropine (0.1 mg kg−1 i.p.), Eserine (0.01 mg kg−1 i.p.), or Hemicholinium-3 (5 μg kg−1 i.p.) in non-adrenalectomized rats. Rats administered acetylcholine (0.01 mg kg−1 i.v.) did not undergo EA. Adrenalectomized rats underwent EA at bilateral ST-36 acupoints without further treatment. Blood samples were drawn from all rats before and after EA to measure changes in plasma glucose levels. Expression of insulin signaling proteins (IRS1, AKT2) in atropine-exposed rats before and after EA was measured by western blot. Atropine and hemicholinium-3 completely blocked the plasma glucose lowering effects of EA, whereas eserine led to a significant hypoglycemic response. In addition, plasma glucose levels after administration of acetylcholine were significantly lower than the fasting glucose levels. In STZ-adrenalectomized rats, EA did not induce a hypoglycemic response. EA stimulated the expression of IRS1 and AKT2 and atropine treatment blocked the EA-induced expression of those insulin signaling proteins. Taken together, EA at the ST-36 acupoint reduces plasma glucose concentrations by stimulating the cholinergic nerves.</abstract><cop>Cairo, Egypt</cop><pub>Hindawi Puplishing Corporation</pub><pmid>21799686</pmid><doi>10.1093/ecam/neq068</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1741-427X |
| ispartof | Evidence-based complementary and alternative medicine, 2011-01, Vol.2011 (2011), p.1-6 |
| issn | 1741-427X 1741-4288 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3136799 |
| source | Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central Open Access; Wiley Online Library (Open Access Collection); PubMed Central; Alma/SFX Local Collection |
| subjects | Acetylcholine Acupuncture AKT2 protein Atropine Cholinergic nerves Diabetes mellitus Diabetes mellitus (insulin dependent) Diabetes mellitus (non-insulin dependent) Electroacupuncture Femur Glucose Hypoglycemia Insulin Insulin resistance Kinases Nerves Neurosciences Original Physostigmine Plasma Proteins Rats Rodents Streptozocin Tempering |
| title | Electroacupuncture at the Zusanli (ST-36) Acupoint Induces a Hypoglycemic Effect by Stimulating the Cholinergic Nerve in a Rat Model of Streptozotocine-Induced Insulin-Dependent Diabetes Mellitus |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-14T20%3A57%3A46IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Electroacupuncture%20at%20the%20Zusanli%20(ST-36)%20Acupoint%20Induces%20a%20Hypoglycemic%20Effect%20by%20Stimulating%20the%20Cholinergic%20Nerve%20in%20a%20Rat%20Model%20of%20Streptozotocine-Induced%20Insulin-Dependent%20Diabetes%20Mellitus&rft.jtitle=Evidence-based%20complementary%20and%20alternative%20medicine&rft.au=Lee,%20Yu-Chen&rft.date=2011-01-01&rft.volume=2011&rft.issue=2011&rft.spage=1&rft.epage=6&rft.pages=1-6&rft.issn=1741-427X&rft.eissn=1741-4288&rft_id=info:doi/10.1093/ecam/neq068&rft_dat=%3Cproquest_pubme%3E2060804830%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2060804830&rft_id=info:pmid/21799686&rfr_iscdi=true |