Simulated Surface-Induced Thrombin Generation in a Flow Field

A computational model of blood coagulation is presented with particular emphasis on the regulatory effects of blood flow, spatial distribution of tissue factor (TF), and the importance of the thrombomodulin-activated protein C inhibitory pathway. We define an effective prothrombotic zone that extend...

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Veröffentlicht in:	Biophysical journal 2011-07, Vol.101 (2), p.276-286
Hauptverfasser:	Jordan, S.W., Chaikof, E.L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological Systems and Multicellular Dynamics Blood blood coagulation blood flow coagulation Computer Simulation Enzymes Finite Element Analysis Molecules Protein C - metabolism Prothrombin - metabolism Rheology Simulation Stress, Mechanical Surface Properties thrombin Thrombin - metabolism Thrombomodulin - metabolism Thromboplastin - metabolism tissue distribution Tissues
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