Chemotactic cell trapping in controlled alternating gradient fields

Directed cell migration toward spatio-temporally varying chemotactic stimuli requires rapid cytoskeletal reorganization. Numerous studies provide evidence that actin reorganization is controlled by intracellular redistribution of signaling molecules, such as the PI4,5P2/PI3,4,5P3 gradient. However,...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2011-07, Vol.108 (28), p.11417-11422
Hauptverfasser:	Meier, BÃ¶rn, Zielinski, Alejandro, Weber, Christoph, Arcizet, Delphine, Youssef, Simon, Franosch, Thomas, RÃ¤dler, Joachim O, Heinrich, Doris
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase Actin Actins Actins - metabolism Aggregation Bacteria Biological Sciences Biophysical Phenomena Cell adhesion & migration Cell migration Cell motility cell movement Chemotactic Factors - administration & dosage Chemotaxis Chemotaxis - drug effects Chemotaxis - physiology Cortex Culture Media Cytoskeleton Dictyostelium - drug effects Dictyostelium - physiology Dictyostelium discoideum Endothelial cells External stimuli Feedback Finite Element Analysis Fluorescence Fusion protein Gradient fields Intracellular signalling Kinases Microfluidic Analytical Techniques Microfluidics Models, Biological Movement - physiology Neurons Phosphatidylinositol 3-Kinases - metabolism Physical Sciences Polarity Polarization Polymerization Protozoan Proteins - metabolism Signal Transduction - drug effects Signal Transduction - physiology Starvation Statistical analysis Trapping
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