Isolation of Bioactive Compounds That Relate to the Anti-Platelet Activity of Cymbopogon ambiguus
Infusions and decoctions of Cymbopogon ambiguus have been used traditionally in Australia for the treatment of headache, chest infections and muscle cramps. The aim of the present study was to screen and identify bioactive compounds from C. ambiguus that could explain this plant’s anti-headache acti...
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| Veröffentlicht in: | Evidence-based complementary and alternative medicine 2011-01, Vol.2011 (2011), p.1-8 |
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| creator | Grice, I. Darren Rogers, Kelly L. Griffiths, Lyn R. |
| description | Infusions and decoctions of Cymbopogon ambiguus have been used traditionally in Australia for the treatment of headache, chest infections and muscle cramps. The aim of the present study was to screen and identify bioactive compounds from C. ambiguus that could explain this plant’s anti-headache activity. A dichloromethane extract of C. ambiguus was identified as having activity in adenosine-diphosphate-induced human platelet aggregation and serotonin-release inhibition bioassays. Subsequent fractionation of this extract led to the isolation of four phenylpropenoids, eugenol, elemicin, eugenol methylether and trans-isoelemicin. While both eugenol and elemicin exhibited dose-dependent inhibition of ADP-induced human platelet serotonin release, only eugenol displayed potent inhibitory activity with an IC50 value of 46.6 μM, in comparison to aspirin, with an IC50 value of 46.1 μM. These findings provide evidence to support the therapeutic efficacy of C. ambiguus in the non-conventional treatment of headache and inflammatory conditions. |
| doi_str_mv | 10.1093/ecam/nep213 |
| format | Article |
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Darren ; Rogers, Kelly L. ; Griffiths, Lyn R.</creator><creatorcontrib>Grice, I. Darren ; Rogers, Kelly L. ; Griffiths, Lyn R.</creatorcontrib><description>Infusions and decoctions of Cymbopogon ambiguus have been used traditionally in Australia for the treatment of headache, chest infections and muscle cramps. The aim of the present study was to screen and identify bioactive compounds from C. ambiguus that could explain this plant’s anti-headache activity. A dichloromethane extract of C. ambiguus was identified as having activity in adenosine-diphosphate-induced human platelet aggregation and serotonin-release inhibition bioassays. Subsequent fractionation of this extract led to the isolation of four phenylpropenoids, eugenol, elemicin, eugenol methylether and trans-isoelemicin. While both eugenol and elemicin exhibited dose-dependent inhibition of ADP-induced human platelet serotonin release, only eugenol displayed potent inhibitory activity with an IC50 value of 46.6 μM, in comparison to aspirin, with an IC50 value of 46.1 μM. These findings provide evidence to support the therapeutic efficacy of C. ambiguus in the non-conventional treatment of headache and inflammatory conditions.</description><identifier>ISSN: 1741-427X</identifier><identifier>EISSN: 1741-4288</identifier><identifier>DOI: 10.1093/ecam/nep213</identifier><identifier>PMID: 20047890</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Puplishing Corporation</publisher><subject>Adenosine ; Adenosine diphosphate ; Alternative medicine ; Aspirin ; Bioactive compounds ; Biochemistry ; Cardiovascular disease ; Cramps ; Cymbopogon ambiguus ; Dichloromethane ; Eugenol ; Fractionation ; Headache ; Headaches ; Inflammation ; Inhibition ; Migraine ; Muscles ; Original ; Platelet aggregation ; Serotonin</subject><ispartof>Evidence-based complementary and alternative medicine, 2011-01, Vol.2011 (2011), p.1-8</ispartof><rights>Copyright © 2011 I. Darren Grice et al.</rights><rights>Copyright © 2011 I. Darren Grice et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. https://creativecommons.org/licenses/by/4.0</rights><rights>Copyright © 2011 I. Darren Grice et al. 2011</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c466t-2dcd8489200e90edf7a8993fbece838cb4bd00f5c7288df2ae9fbdccb4cf0fa43</citedby><cites>FETCH-LOGICAL-c466t-2dcd8489200e90edf7a8993fbece838cb4bd00f5c7288df2ae9fbdccb4cf0fa43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3135635/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3135635/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20047890$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Grice, I. Darren</creatorcontrib><creatorcontrib>Rogers, Kelly L.</creatorcontrib><creatorcontrib>Griffiths, Lyn R.</creatorcontrib><title>Isolation of Bioactive Compounds That Relate to the Anti-Platelet Activity of Cymbopogon ambiguus</title><title>Evidence-based complementary and alternative medicine</title><addtitle>Evid Based Complement Alternat Med</addtitle><description>Infusions and decoctions of Cymbopogon ambiguus have been used traditionally in Australia for the treatment of headache, chest infections and muscle cramps. The aim of the present study was to screen and identify bioactive compounds from C. ambiguus that could explain this plant’s anti-headache activity. A dichloromethane extract of C. ambiguus was identified as having activity in adenosine-diphosphate-induced human platelet aggregation and serotonin-release inhibition bioassays. Subsequent fractionation of this extract led to the isolation of four phenylpropenoids, eugenol, elemicin, eugenol methylether and trans-isoelemicin. While both eugenol and elemicin exhibited dose-dependent inhibition of ADP-induced human platelet serotonin release, only eugenol displayed potent inhibitory activity with an IC50 value of 46.6 μM, in comparison to aspirin, with an IC50 value of 46.1 μM. These findings provide evidence to support the therapeutic efficacy of C. ambiguus in the non-conventional treatment of headache and inflammatory conditions.</description><subject>Adenosine</subject><subject>Adenosine diphosphate</subject><subject>Alternative medicine</subject><subject>Aspirin</subject><subject>Bioactive compounds</subject><subject>Biochemistry</subject><subject>Cardiovascular disease</subject><subject>Cramps</subject><subject>Cymbopogon ambiguus</subject><subject>Dichloromethane</subject><subject>Eugenol</subject><subject>Fractionation</subject><subject>Headache</subject><subject>Headaches</subject><subject>Inflammation</subject><subject>Inhibition</subject><subject>Migraine</subject><subject>Muscles</subject><subject>Original</subject><subject>Platelet aggregation</subject><subject>Serotonin</subject><issn>1741-427X</issn><issn>1741-4288</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>RHX</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqFkUGL1DAYhoMo7rp68qwEvIhSN2naJrkI47DqwoIiK3gLafJlJkvb1CZdmX-_KV0H9eIp4cuTh_fjReg5Je8okewcjO7PBxhLyh6gU8orWlSlEA-Pd_7jBD2J8YaQUnLOH6OTkpCKC0lOkb6ModPJhwEHhz_4oE3yt4C3oR_DPNiIr_c64W-QIcAp4LQHvBmSL74ukw4S3iw_fDosgu2hb8MYdlmn-9bv5jk-RY-c7iI8uz_P0PePF9fbz8XVl0-X281VYaqmSUVpjRWVkDkaSALWcS2kZK4FA4IJ01atJcTVhufdrCs1SNdak-fGEacrdober95xbnuwBoY06U6Nk-_1dFBBe_X3y-D3ahduFaOsblidBa_vBVP4OUNMqvfRQNfpAcIcFeVN2QhSc5bRV_-gN2GehryeKklDBKE1J5l6u1JmCjFO4I5hKFFLdWqpTq3VZfrln_mP7O-uMvBmBfZ-sPqX_4_txQpDRsDpI1xxxiVldxHFsOo</recordid><startdate>20110101</startdate><enddate>20110101</enddate><creator>Grice, I. Darren</creator><creator>Rogers, Kelly L.</creator><creator>Griffiths, Lyn R.</creator><general>Hindawi Puplishing Corporation</general><general>Hindawi Publishing Corporation</general><general>Hindawi Limited</general><scope>ADJCN</scope><scope>AHFXO</scope><scope>RHU</scope><scope>RHW</scope><scope>RHX</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7T5</scope><scope>7TO</scope><scope>7X7</scope><scope>7XB</scope><scope>88G</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M2M</scope><scope>M2O</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20110101</creationdate><title>Isolation of Bioactive Compounds That Relate to the Anti-Platelet Activity of Cymbopogon ambiguus</title><author>Grice, I. Darren ; Rogers, Kelly L. ; Griffiths, Lyn R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c466t-2dcd8489200e90edf7a8993fbece838cb4bd00f5c7288df2ae9fbdccb4cf0fa43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adenosine</topic><topic>Adenosine diphosphate</topic><topic>Alternative medicine</topic><topic>Aspirin</topic><topic>Bioactive compounds</topic><topic>Biochemistry</topic><topic>Cardiovascular disease</topic><topic>Cramps</topic><topic>Cymbopogon ambiguus</topic><topic>Dichloromethane</topic><topic>Eugenol</topic><topic>Fractionation</topic><topic>Headache</topic><topic>Headaches</topic><topic>Inflammation</topic><topic>Inhibition</topic><topic>Migraine</topic><topic>Muscles</topic><topic>Original</topic><topic>Platelet aggregation</topic><topic>Serotonin</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Grice, I. 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Darren</au><au>Rogers, Kelly L.</au><au>Griffiths, Lyn R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Isolation of Bioactive Compounds That Relate to the Anti-Platelet Activity of Cymbopogon ambiguus</atitle><jtitle>Evidence-based complementary and alternative medicine</jtitle><addtitle>Evid Based Complement Alternat Med</addtitle><date>2011-01-01</date><risdate>2011</risdate><volume>2011</volume><issue>2011</issue><spage>1</spage><epage>8</epage><pages>1-8</pages><issn>1741-427X</issn><eissn>1741-4288</eissn><abstract>Infusions and decoctions of Cymbopogon ambiguus have been used traditionally in Australia for the treatment of headache, chest infections and muscle cramps. The aim of the present study was to screen and identify bioactive compounds from C. ambiguus that could explain this plant’s anti-headache activity. A dichloromethane extract of C. ambiguus was identified as having activity in adenosine-diphosphate-induced human platelet aggregation and serotonin-release inhibition bioassays. Subsequent fractionation of this extract led to the isolation of four phenylpropenoids, eugenol, elemicin, eugenol methylether and trans-isoelemicin. While both eugenol and elemicin exhibited dose-dependent inhibition of ADP-induced human platelet serotonin release, only eugenol displayed potent inhibitory activity with an IC50 value of 46.6 μM, in comparison to aspirin, with an IC50 value of 46.1 μM. These findings provide evidence to support the therapeutic efficacy of C. ambiguus in the non-conventional treatment of headache and inflammatory conditions.</abstract><cop>Cairo, Egypt</cop><pub>Hindawi Puplishing Corporation</pub><pmid>20047890</pmid><doi>10.1093/ecam/nep213</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Evidence-based complementary and alternative medicine, 2011-01, Vol.2011 (2011), p.1-8 |
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| source | Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central Open Access; Wiley-Blackwell Open Access Titles; PubMed Central; Alma/SFX Local Collection |
| subjects | Adenosine Adenosine diphosphate Alternative medicine Aspirin Bioactive compounds Biochemistry Cardiovascular disease Cramps Cymbopogon ambiguus Dichloromethane Eugenol Fractionation Headache Headaches Inflammation Inhibition Migraine Muscles Original Platelet aggregation Serotonin |
| title | Isolation of Bioactive Compounds That Relate to the Anti-Platelet Activity of Cymbopogon ambiguus |
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