Informatic and Functional Approaches to Identifying a Regulatory Region for the Cardiac Sodium Channel

RATIONALE:Although multiple lines of evidence suggest that variable expression of the cardiac sodium channel gene SCN5A plays a role in susceptibility to arrhythmia, little is known about its transcriptional regulation. OBJECTIVE:We used in silico and in vitro experiments to identify possible noncod...

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Veröffentlicht in:	Circulation research 2011-06, Vol.109 (1), p.38-46
Hauptverfasser:	Atack, Thomas C, Myers Stroud, Dina, Watanabe, Hiroshi, Yang, Tao, Hall, Lynn, Hipkens, Susan B, Lowe, John S, Leake, Brenda, Magnuson, Mark A, Yang, Ping, Roden, Dan M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Base Sequence Biological and medical sciences CHO Cells Conserved Sequence Cricetinae Cricetulus Electrocardiography Fundamental and applied biological sciences. Psychology Gene Expression Regulation Heart Humans Mice Molecular Sequence Data NAV1.5 Voltage-Gated Sodium Channel Promoter Regions, Genetic Regulatory Sequences, Nucleic Acid Sodium Channels - genetics Sodium Channels - physiology Transcription, Genetic Vertebrates: cardiovascular system
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