The Role of Platelet Factor 4 in Radiation-Induced Thrombocytopenia

Purpose Factors affecting the severity of radiation-induced thrombocytopenia (RIT) are not well described. We address whether platelet factor 4 (PF4; a negative paracrine for megakaryopoiesis) affects platelet recovery postradiation. Methods and Materials Using conditioned media from irradiated bone...

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Veröffentlicht in:	International journal of radiation oncology, biology, physics biology, physics, 2011-08, Vol.80 (5), p.1533-1540
Hauptverfasser:	Lambert, Michele P., M.D, Xiao, Liqing, Ph.D, Nguyen, Yvonne, Kowalska, M. Anna, Ph.D, Poncz, Mortimer, M.D
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES ANIMAL CELLS ANIMAL TISSUES ANIMALS ANTIBODIES Biological and medical sciences BIOLOGICAL MATERIALS BLOOD BLOOD CELLS BLOOD PLATELETS Blood Platelets - cytology Blood Platelets - radiation effects BODY BODY FLUIDS BONE MARROW Bone Marrow - radiation effects BONE MARROW CELLS Cell Survival - drug effects Cell Survival - physiology Cell Survival - radiation effects Chemokines COLONY FORMATION Colony-Forming Units Assay - methods CONNECTIVE TISSUE CELLS Culture Media, Conditioned - radiation effects Cytokines GROWTH FACTORS Hematologic and hematopoietic diseases Hematology, Oncology and Palliative Medicine HEMATOPOIETIC SYSTEM Humans LIPIDS LIPOPROTEINS LYMPHOKINES MAMMALS MATERIALS Medical sciences MEDICINE Megakaryocytes - cytology Megakaryocytes - drug effects Megakaryocytes - metabolism Megakaryocytes - radiation effects MEMBRANE PROTEINS MICE Mice, Knockout Mice, Transgenic MITOGENS ORGANIC COMPOUNDS ORGANS Platelet Count Platelet diseases and coagulopathies Platelet factor 4 Platelet Factor 4 - antagonists & inhibitors Platelet Factor 4 - physiology POST-IRRADIATION THERAPY PROTEINS Radiation-induced thrombocytopenia Radiology RECEPTORS Receptors, LDL - antagonists & inhibitors RODENTS SOMATIC CELLS THERAPY Thrombocytopenia - blood Thrombocytopenia - drug therapy Thrombocytopenia - etiology Thrombopoiesis - drug effects Thrombopoiesis - physiology Thrombopoiesis - radiation effects Thrombopoietin Thrombopoietin - pharmacology TRANSGENIC ANIMALS TRANSGENIC MICE Tumor Suppressor Proteins - antagonists & inhibitors VERTEBRATES
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