Effects of Spray Drying on Physicochemical Properties of Chitosan Acid Salts
The effects of spray-drying process and acidic solvent system on physicochemical properties of chitosan salts were investigated. Chitosan used in spray dryings was obtained by deacetylation of chitin from lobster ( Panulirus argus ) origin. The chitosan acid salts were prepared in a laboratory-scale...
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| Veröffentlicht in: | AAPS PharmSciTech 2011-06, Vol.12 (2), p.637-649 |
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| creator | Cervera, Mirna Fernández Heinämäki, Jyrki de la Paz, Nilia López, Orestes Maunu, Sirkka Liisa Virtanen, Tommi Hatanpää, Timo Antikainen, Osmo Nogueira, Antonio Fundora, Jorge Yliruusi, Jouko |
| description | The effects of spray-drying process and acidic solvent system on physicochemical properties of chitosan salts were investigated. Chitosan used in spray dryings was obtained by deacetylation of chitin from lobster (
Panulirus argus
) origin. The chitosan acid salts were prepared in a laboratory-scale spray drier, and organic acetic acid, lactic acid, and citric acid were used as solvents in the process. The physicochemical properties of chitosan salts were investigated by means of solid-state CP-MAS
13
C nuclear magnetic resonance (NMR), X-ray powder diffraction (XRPD), differential scanning calorimetry, and Fourier transform infrared spectrometry (FTIR) and near-infrared spectroscopy. The morphology of spray-dried chitosan acid salts showed tendency toward higher sphericity when higher temperatures in a spray-drying process were applied. Analysis by XRPD indicated that all chitosan acid salts studied were amorphous solids. Solid-state
13
C NMR spectra revealed the evidence of the partial conversion of chitosan acetate to chitin and also conversion to acetyl amide form which appears to be dependent on the spray-drying process. The FTIR spectra suggested that the organic acids applied in spray drying may interact with chitosan at the position of amino groups to form chitosan salts. With all three chitosan acid salts, the FTIR bands at 1,597 and 1,615 cm
−1
were diminished suggesting that –NH groups are protonated. The FTIR spectra of all chitosan acid salts exhibited ammonium and carboxylate bands at 1,630 and 1,556 cm
−1
, respectively. In conclusion, spray drying is a potential method of preparing acid salts from chitosan obtained by deacetylation of chitin from lobster (
P. argus
) origin. |
| doi_str_mv | 10.1208/s12249-011-9620-3 |
| format | Article |
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Panulirus argus
) origin. The chitosan acid salts were prepared in a laboratory-scale spray drier, and organic acetic acid, lactic acid, and citric acid were used as solvents in the process. The physicochemical properties of chitosan salts were investigated by means of solid-state CP-MAS
13
C nuclear magnetic resonance (NMR), X-ray powder diffraction (XRPD), differential scanning calorimetry, and Fourier transform infrared spectrometry (FTIR) and near-infrared spectroscopy. The morphology of spray-dried chitosan acid salts showed tendency toward higher sphericity when higher temperatures in a spray-drying process were applied. Analysis by XRPD indicated that all chitosan acid salts studied were amorphous solids. Solid-state
13
C NMR spectra revealed the evidence of the partial conversion of chitosan acetate to chitin and also conversion to acetyl amide form which appears to be dependent on the spray-drying process. The FTIR spectra suggested that the organic acids applied in spray drying may interact with chitosan at the position of amino groups to form chitosan salts. With all three chitosan acid salts, the FTIR bands at 1,597 and 1,615 cm
−1
were diminished suggesting that –NH groups are protonated. The FTIR spectra of all chitosan acid salts exhibited ammonium and carboxylate bands at 1,630 and 1,556 cm
−1
, respectively. In conclusion, spray drying is a potential method of preparing acid salts from chitosan obtained by deacetylation of chitin from lobster (
P. argus
) origin.</description><identifier>ISSN: 1530-9932</identifier><identifier>EISSN: 1530-9932</identifier><identifier>DOI: 10.1208/s12249-011-9620-3</identifier><identifier>PMID: 21560022</identifier><language>eng</language><publisher>Boston: Springer US</publisher><subject>Acetic Acid - chemistry ; Acetic Acid - standards ; Animals ; Biochemistry ; Biomedical and Life Sciences ; Biomedicine ; Biotechnology ; Chemistry, Pharmaceutical - methods ; Chemistry, Pharmaceutical - standards ; Chitosan - chemistry ; Chitosan - isolation & purification ; Chitosan - standards ; Homarus americanus ; Lactic Acid - chemistry ; Lactic Acid - standards ; Marine ; Palinuridae ; Panulirus argus ; Particle Size ; Pharmacology/Toxicology ; Pharmacy ; Research Article ; Salts - chemistry ; Salts - standards</subject><ispartof>AAPS PharmSciTech, 2011-06, Vol.12 (2), p.637-649</ispartof><rights>American Association of Pharmaceutical Scientists 2011</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c614t-4df9435730c290730db5a9cc4f52d618feaaeac8d32c7c3fa4c16717d6705fa33</citedby><cites>FETCH-LOGICAL-c614t-4df9435730c290730db5a9cc4f52d618feaaeac8d32c7c3fa4c16717d6705fa33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3134675/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3134675/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,41488,42557,51319,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21560022$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cervera, Mirna Fernández</creatorcontrib><creatorcontrib>Heinämäki, Jyrki</creatorcontrib><creatorcontrib>de la Paz, Nilia</creatorcontrib><creatorcontrib>López, Orestes</creatorcontrib><creatorcontrib>Maunu, Sirkka Liisa</creatorcontrib><creatorcontrib>Virtanen, Tommi</creatorcontrib><creatorcontrib>Hatanpää, Timo</creatorcontrib><creatorcontrib>Antikainen, Osmo</creatorcontrib><creatorcontrib>Nogueira, Antonio</creatorcontrib><creatorcontrib>Fundora, Jorge</creatorcontrib><creatorcontrib>Yliruusi, Jouko</creatorcontrib><title>Effects of Spray Drying on Physicochemical Properties of Chitosan Acid Salts</title><title>AAPS PharmSciTech</title><addtitle>AAPS PharmSciTech</addtitle><addtitle>AAPS PharmSciTech</addtitle><description>The effects of spray-drying process and acidic solvent system on physicochemical properties of chitosan salts were investigated. Chitosan used in spray dryings was obtained by deacetylation of chitin from lobster (
Panulirus argus
) origin. The chitosan acid salts were prepared in a laboratory-scale spray drier, and organic acetic acid, lactic acid, and citric acid were used as solvents in the process. The physicochemical properties of chitosan salts were investigated by means of solid-state CP-MAS
13
C nuclear magnetic resonance (NMR), X-ray powder diffraction (XRPD), differential scanning calorimetry, and Fourier transform infrared spectrometry (FTIR) and near-infrared spectroscopy. The morphology of spray-dried chitosan acid salts showed tendency toward higher sphericity when higher temperatures in a spray-drying process were applied. Analysis by XRPD indicated that all chitosan acid salts studied were amorphous solids. Solid-state
13
C NMR spectra revealed the evidence of the partial conversion of chitosan acetate to chitin and also conversion to acetyl amide form which appears to be dependent on the spray-drying process. The FTIR spectra suggested that the organic acids applied in spray drying may interact with chitosan at the position of amino groups to form chitosan salts. With all three chitosan acid salts, the FTIR bands at 1,597 and 1,615 cm
−1
were diminished suggesting that –NH groups are protonated. The FTIR spectra of all chitosan acid salts exhibited ammonium and carboxylate bands at 1,630 and 1,556 cm
−1
, respectively. In conclusion, spray drying is a potential method of preparing acid salts from chitosan obtained by deacetylation of chitin from lobster (
P. argus
) origin.</description><subject>Acetic Acid - chemistry</subject><subject>Acetic Acid - standards</subject><subject>Animals</subject><subject>Biochemistry</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Biotechnology</subject><subject>Chemistry, Pharmaceutical - methods</subject><subject>Chemistry, Pharmaceutical - standards</subject><subject>Chitosan - chemistry</subject><subject>Chitosan - isolation & purification</subject><subject>Chitosan - standards</subject><subject>Homarus americanus</subject><subject>Lactic Acid - chemistry</subject><subject>Lactic Acid - standards</subject><subject>Marine</subject><subject>Palinuridae</subject><subject>Panulirus argus</subject><subject>Particle Size</subject><subject>Pharmacology/Toxicology</subject><subject>Pharmacy</subject><subject>Research Article</subject><subject>Salts - chemistry</subject><subject>Salts - standards</subject><issn>1530-9932</issn><issn>1530-9932</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kV1PwyAUhonRuDn9Ad6Y3ulNlQOFtjcmy5wfyRKXTK8Jo7CxdGVCZ9J_b_fhoje74UDOwxsOD0LXgO-B4OwhACFJHmOAOOcEx_QEdYFRHOc5Jad_9h10EcICY0Ihp-eoQ4Dx9kS6aDQ0Rqs6RM5Ek5WXTfTkG1vNIldF43kTrHJqrpdWyTIae7fSvrZ6Sw_mtnZBVlFf2SKayLIOl-jMyDLoq33toc_n4cfgNR69v7wN-qNYcUjqOClMnlCWUqxIjttSTJnMlUoMIwWHzGgptVRZQYlKFTUyUcBTSAueYmYkpT30uMtdradLXShd1V6WYuXtUvpGOGnF_05l52LmvgUFmvCUtQG3-wDvvtY61GJpg9JlKSvt1kFkKc-AsS15d5QEIIxQzNulh2CHKu9C8NocHgRYbHyJnS_R-hIbX2Izyc3fSQ43fgW1ANkBoW1VM-3Fwq191f7ukdQf_4yg5A</recordid><startdate>20110601</startdate><enddate>20110601</enddate><creator>Cervera, Mirna Fernández</creator><creator>Heinämäki, Jyrki</creator><creator>de la Paz, Nilia</creator><creator>López, Orestes</creator><creator>Maunu, Sirkka Liisa</creator><creator>Virtanen, Tommi</creator><creator>Hatanpää, Timo</creator><creator>Antikainen, Osmo</creator><creator>Nogueira, Antonio</creator><creator>Fundora, Jorge</creator><creator>Yliruusi, Jouko</creator><general>Springer US</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7TN</scope><scope>8FD</scope><scope>F1W</scope><scope>FR3</scope><scope>H95</scope><scope>L.G</scope><scope>P64</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20110601</creationdate><title>Effects of Spray Drying on Physicochemical Properties of Chitosan Acid Salts</title><author>Cervera, Mirna Fernández ; 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Chitosan used in spray dryings was obtained by deacetylation of chitin from lobster (
Panulirus argus
) origin. The chitosan acid salts were prepared in a laboratory-scale spray drier, and organic acetic acid, lactic acid, and citric acid were used as solvents in the process. The physicochemical properties of chitosan salts were investigated by means of solid-state CP-MAS
13
C nuclear magnetic resonance (NMR), X-ray powder diffraction (XRPD), differential scanning calorimetry, and Fourier transform infrared spectrometry (FTIR) and near-infrared spectroscopy. The morphology of spray-dried chitosan acid salts showed tendency toward higher sphericity when higher temperatures in a spray-drying process were applied. Analysis by XRPD indicated that all chitosan acid salts studied were amorphous solids. Solid-state
13
C NMR spectra revealed the evidence of the partial conversion of chitosan acetate to chitin and also conversion to acetyl amide form which appears to be dependent on the spray-drying process. The FTIR spectra suggested that the organic acids applied in spray drying may interact with chitosan at the position of amino groups to form chitosan salts. With all three chitosan acid salts, the FTIR bands at 1,597 and 1,615 cm
−1
were diminished suggesting that –NH groups are protonated. The FTIR spectra of all chitosan acid salts exhibited ammonium and carboxylate bands at 1,630 and 1,556 cm
−1
, respectively. In conclusion, spray drying is a potential method of preparing acid salts from chitosan obtained by deacetylation of chitin from lobster (
P. argus
) origin.</abstract><cop>Boston</cop><pub>Springer US</pub><pmid>21560022</pmid><doi>10.1208/s12249-011-9620-3</doi><tpages>13</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Acetic Acid - chemistry Acetic Acid - standards Animals Biochemistry Biomedical and Life Sciences Biomedicine Biotechnology Chemistry, Pharmaceutical - methods Chemistry, Pharmaceutical - standards Chitosan - chemistry Chitosan - isolation & purification Chitosan - standards Homarus americanus Lactic Acid - chemistry Lactic Acid - standards Marine Palinuridae Panulirus argus Particle Size Pharmacology/Toxicology Pharmacy Research Article Salts - chemistry Salts - standards |
| title | Effects of Spray Drying on Physicochemical Properties of Chitosan Acid Salts |
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