Diminished Gray Matter Within the Hypothalamus in Autism Disorder: A Potential Link to Hormonal Effects?
Background Subjects with autism suffer from impairments of social interaction, deviations in language usage, as well as restricted and stereotyped patterns of behavior. These characteristics are found irrespective of age, IQ, and gender of affected subjects. However, brain changes due to age, IQ, an...
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| Veröffentlicht in: | Biological psychiatry (1969) 2011-08, Vol.70 (3), p.278-282 |
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| creator | Kurth, Florian Narr, Katherine L Woods, Roger P O'Neill, Joseph Alger, Jeffry R Caplan, Rochelle McCracken, James T Toga, Arthur W Levitt, Jennifer G |
| description | Background Subjects with autism suffer from impairments of social interaction, deviations in language usage, as well as restricted and stereotyped patterns of behavior. These characteristics are found irrespective of age, IQ, and gender of affected subjects. However, brain changes due to age, IQ, and gender might pose potential confounds in autism neuroimaging analyses. Methods To investigate gray matter differences in autism that are not related to these potential confounds, we performed a voxel-based morphometry analysis in 52 affected children and adolescents and 52 matched control subjects. Results We observed diminished gray matter in a region of the hypothalamus, which synthesizes the behaviorally relevant hormones oxytocin and arginine vasopressin. Conclusions This finding provides support for further investigations of the theory of abnormal functioning of this hormonal system in autism and potentially for experimental therapeutic approaches with oxytocin and related neuropeptides. |
| doi_str_mv | 10.1016/j.biopsych.2011.03.026 |
| format | Article |
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These characteristics are found irrespective of age, IQ, and gender of affected subjects. However, brain changes due to age, IQ, and gender might pose potential confounds in autism neuroimaging analyses. Methods To investigate gray matter differences in autism that are not related to these potential confounds, we performed a voxel-based morphometry analysis in 52 affected children and adolescents and 52 matched control subjects. Results We observed diminished gray matter in a region of the hypothalamus, which synthesizes the behaviorally relevant hormones oxytocin and arginine vasopressin. Conclusions This finding provides support for further investigations of the theory of abnormal functioning of this hormonal system in autism and potentially for experimental therapeutic approaches with oxytocin and related neuropeptides.</description><identifier>ISSN: 0006-3223</identifier><identifier>EISSN: 1873-2402</identifier><identifier>DOI: 10.1016/j.biopsych.2011.03.026</identifier><identifier>PMID: 21531390</identifier><identifier>CODEN: BIPCBF</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Adolescent ; Adolescents ; ASD ; Autistic Disorder - pathology ; Biological and medical sciences ; Child ; Child clinical studies ; Child, Preschool ; children ; Developmental disorders ; Female ; Humans ; Hypothalamus - pathology ; Infantile autism ; Magnetic Resonance Imaging ; Male ; Medical sciences ; morphometry ; Nerve Fibers, Unmyelinated - pathology ; Organ Size ; oxytocin ; Pituitary Hormones, Posterior - physiology ; Psychiatry ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; voxel-based morphometry (VBM) ; Young Adult</subject><ispartof>Biological psychiatry (1969), 2011-08, Vol.70 (3), p.278-282</ispartof><rights>Society of Biological Psychiatry</rights><rights>2011 Society of Biological Psychiatry</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2011 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.</rights><rights>2011 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved. 2011</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c621t-ae725549be08d711dad5c13962a9ce2a038a7582a22df0c6d01b9851e5cea3b3</citedby><cites>FETCH-LOGICAL-c621t-ae725549be08d711dad5c13962a9ce2a038a7582a22df0c6d01b9851e5cea3b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.biopsych.2011.03.026$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,780,784,885,3548,27923,27924,45994</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24391858$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21531390$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kurth, Florian</creatorcontrib><creatorcontrib>Narr, Katherine L</creatorcontrib><creatorcontrib>Woods, Roger P</creatorcontrib><creatorcontrib>O'Neill, Joseph</creatorcontrib><creatorcontrib>Alger, Jeffry R</creatorcontrib><creatorcontrib>Caplan, Rochelle</creatorcontrib><creatorcontrib>McCracken, James T</creatorcontrib><creatorcontrib>Toga, Arthur W</creatorcontrib><creatorcontrib>Levitt, Jennifer G</creatorcontrib><title>Diminished Gray Matter Within the Hypothalamus in Autism Disorder: A Potential Link to Hormonal Effects?</title><title>Biological psychiatry (1969)</title><addtitle>Biol Psychiatry</addtitle><description>Background Subjects with autism suffer from impairments of social interaction, deviations in language usage, as well as restricted and stereotyped patterns of behavior. These characteristics are found irrespective of age, IQ, and gender of affected subjects. However, brain changes due to age, IQ, and gender might pose potential confounds in autism neuroimaging analyses. Methods To investigate gray matter differences in autism that are not related to these potential confounds, we performed a voxel-based morphometry analysis in 52 affected children and adolescents and 52 matched control subjects. Results We observed diminished gray matter in a region of the hypothalamus, which synthesizes the behaviorally relevant hormones oxytocin and arginine vasopressin. Conclusions This finding provides support for further investigations of the theory of abnormal functioning of this hormonal system in autism and potentially for experimental therapeutic approaches with oxytocin and related neuropeptides.</description><subject>Adolescent</subject><subject>Adolescents</subject><subject>ASD</subject><subject>Autistic Disorder - pathology</subject><subject>Biological and medical sciences</subject><subject>Child</subject><subject>Child clinical studies</subject><subject>Child, Preschool</subject><subject>children</subject><subject>Developmental disorders</subject><subject>Female</subject><subject>Humans</subject><subject>Hypothalamus - pathology</subject><subject>Infantile autism</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Medical sciences</subject><subject>morphometry</subject><subject>Nerve Fibers, Unmyelinated - pathology</subject><subject>Organ Size</subject><subject>oxytocin</subject><subject>Pituitary Hormones, Posterior - physiology</subject><subject>Psychiatry</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><subject>voxel-based morphometry (VBM)</subject><subject>Young Adult</subject><issn>0006-3223</issn><issn>1873-2402</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkltv1DAQhSMEokvhL1R-QTwltcebGw-FVW-LtAgkKvFoOfaEeJvEi-1Uyr_Hq92WywtPlu1vzhzNmSQ5YzRjlBXn26wxdudn1WVAGcsozygUz5IFq0qewpLC82RBKS1SDsBPklfeb-O1BGAvkxNgOWe8poukuzKDGY3vUJNbJ2fyWYaAjnw3oTMjCR2S9byzoZO9HCZP4ttqCsYP5Mp46zS692RFvtqAYzCyJxsz3pNgydq6wY7x4bptUQX_4XXyopW9xzfH8zS5u7m-u1ynmy-3ny5Xm1QVwEIqsYQ8X9YN0kqXjGmpcxWtFiBrhSApr2SZVyABdEtVoSlr6ipnmCuUvOGnycVBdjc1A2oVbTnZi50zg3SzsNKIv39G04kf9kHEeSzzEqLAu6OAsz8n9EEMxivsezminbyoygJ4XVZ1JIsDqZz13mH71IVRsQ9JbMVjSGIfkqBcxJBi4dmfHp_KHlOJwNsjIL2SfevkqIz_zS15zaq8itzHA4dxoA8GnfDK4KhQGxeHLrQ1__dy8Y-E6uM-xK73OKPf2snFFL1gwoOg4tt-pfYbxRilUBY1_wUFNcn8</recordid><startdate>20110801</startdate><enddate>20110801</enddate><creator>Kurth, Florian</creator><creator>Narr, Katherine L</creator><creator>Woods, Roger P</creator><creator>O'Neill, Joseph</creator><creator>Alger, Jeffry R</creator><creator>Caplan, Rochelle</creator><creator>McCracken, James T</creator><creator>Toga, Arthur W</creator><creator>Levitt, Jennifer G</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20110801</creationdate><title>Diminished Gray Matter Within the Hypothalamus in Autism Disorder: A Potential Link to Hormonal Effects?</title><author>Kurth, Florian ; Narr, Katherine L ; Woods, Roger P ; O'Neill, Joseph ; Alger, Jeffry R ; Caplan, Rochelle ; McCracken, James T ; Toga, Arthur W ; Levitt, Jennifer G</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c621t-ae725549be08d711dad5c13962a9ce2a038a7582a22df0c6d01b9851e5cea3b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adolescent</topic><topic>Adolescents</topic><topic>ASD</topic><topic>Autistic Disorder - pathology</topic><topic>Biological and medical sciences</topic><topic>Child</topic><topic>Child clinical studies</topic><topic>Child, Preschool</topic><topic>children</topic><topic>Developmental disorders</topic><topic>Female</topic><topic>Humans</topic><topic>Hypothalamus - pathology</topic><topic>Infantile autism</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Medical sciences</topic><topic>morphometry</topic><topic>Nerve Fibers, Unmyelinated - pathology</topic><topic>Organ Size</topic><topic>oxytocin</topic><topic>Pituitary Hormones, Posterior - physiology</topic><topic>Psychiatry</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><topic>voxel-based morphometry (VBM)</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kurth, Florian</creatorcontrib><creatorcontrib>Narr, Katherine L</creatorcontrib><creatorcontrib>Woods, Roger P</creatorcontrib><creatorcontrib>O'Neill, Joseph</creatorcontrib><creatorcontrib>Alger, Jeffry R</creatorcontrib><creatorcontrib>Caplan, Rochelle</creatorcontrib><creatorcontrib>McCracken, James T</creatorcontrib><creatorcontrib>Toga, Arthur W</creatorcontrib><creatorcontrib>Levitt, Jennifer G</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Biological psychiatry (1969)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kurth, Florian</au><au>Narr, Katherine L</au><au>Woods, Roger P</au><au>O'Neill, Joseph</au><au>Alger, Jeffry R</au><au>Caplan, Rochelle</au><au>McCracken, James T</au><au>Toga, Arthur W</au><au>Levitt, Jennifer G</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Diminished Gray Matter Within the Hypothalamus in Autism Disorder: A Potential Link to Hormonal Effects?</atitle><jtitle>Biological psychiatry (1969)</jtitle><addtitle>Biol Psychiatry</addtitle><date>2011-08-01</date><risdate>2011</risdate><volume>70</volume><issue>3</issue><spage>278</spage><epage>282</epage><pages>278-282</pages><issn>0006-3223</issn><eissn>1873-2402</eissn><coden>BIPCBF</coden><abstract>Background Subjects with autism suffer from impairments of social interaction, deviations in language usage, as well as restricted and stereotyped patterns of behavior. These characteristics are found irrespective of age, IQ, and gender of affected subjects. However, brain changes due to age, IQ, and gender might pose potential confounds in autism neuroimaging analyses. Methods To investigate gray matter differences in autism that are not related to these potential confounds, we performed a voxel-based morphometry analysis in 52 affected children and adolescents and 52 matched control subjects. Results We observed diminished gray matter in a region of the hypothalamus, which synthesizes the behaviorally relevant hormones oxytocin and arginine vasopressin. 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| subjects | Adolescent Adolescents ASD Autistic Disorder - pathology Biological and medical sciences Child Child clinical studies Child, Preschool children Developmental disorders Female Humans Hypothalamus - pathology Infantile autism Magnetic Resonance Imaging Male Medical sciences morphometry Nerve Fibers, Unmyelinated - pathology Organ Size oxytocin Pituitary Hormones, Posterior - physiology Psychiatry Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry voxel-based morphometry (VBM) Young Adult |
| title | Diminished Gray Matter Within the Hypothalamus in Autism Disorder: A Potential Link to Hormonal Effects? |
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