Loss of Tsc1 in vivo impairs hippocampal mGluR-LTD and increases excitatory synaptic function

The autism spectrum disorder tuberous sclerosis complex (TSC) is caused by mutations in the Tsc1 or Tsc2 genes, whose protein products form a heterodimeric complex that negatively regulates mammalian target of rapamycin-dependent protein translation. Although several forms of synaptic plasticity, in...

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