Aborted germinal center reactions and B cell memory by follicular T cells specific for a B cell receptor V region peptide
A fundamental problem in immunoregulation is how CD4(+) T cells react to immunogenic peptides derived from the V region of the BCR that are created by somatic mechanisms, presented in MHC II, and amplified to abundance by B cell clonal expansion during immunity. BCR neo Ags open a potentially danger...
Gespeichert in:
| Veröffentlicht in: | The Journal of immunology (1950) 2011-07, Vol.187 (1), p.212-221 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 221 |
|---|---|
| container_issue | 1 |
| container_start_page | 212 |
| container_title | The Journal of immunology (1950) |
| container_volume | 187 |
| creator | Heiser, Ryan A Snyder, Christopher M St Clair, James Wysocki, Lawrence J |
| description | A fundamental problem in immunoregulation is how CD4(+) T cells react to immunogenic peptides derived from the V region of the BCR that are created by somatic mechanisms, presented in MHC II, and amplified to abundance by B cell clonal expansion during immunity. BCR neo Ags open a potentially dangerous avenue of T cell help in violation of the principle of linked Ag recognition. To analyze this issue, we developed a murine adoptive transfer model using paired donor B cells and CD4 T cells specific for a BCR-derived peptide. BCR peptide-specific T cells aborted ongoing germinal center reactions and impeded the secondary immune response. Instead, they induced the B cells to differentiate into short-lived extrafollicular plasmablasts that secreted modest quantities of Ig. These results uncover an immunoregulatory process that restricts the memory pathway to B cells that communicate with CD4 T cells via exogenous foreign Ag. |
| doi_str_mv | 10.4049/jimmunol.1002328 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3133611</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>904476729</sourcerecordid><originalsourceid>FETCH-LOGICAL-c427t-fb05a3a744634e8cf6a53cbe494b3a528053b13a2d0a0a76eee322199908b5923</originalsourceid><addsrcrecordid>eNqFUctO3DAUtaqiMtDuWVXedRW4fsRJNkgUlYeE1A2wtRznZjBy4tROkObv64EZRFdd2b7noXt8CDlhcCpBNmfPbhiWMfhTBsAFrz-RFStLKJQC9Zms8pAXrFLVITlK6RkAFHD5hRxypjivlVqRzUUb4owdXWMc3Gg8tTjOGGlEY2cXxkTN2NGfeew9HXAIcUPbDe2D984u3kR6_4olmia0rnc2Y5GavSSixWnOk8d8XWdDOuW36_ArOeiNT_htdx6Th6tf95c3xd3v69vLi7vCSl7NRd9CaYSppFRCYm17ZUphW5SNbIUpeQ2laJkwvAMDplKIKDhnTdNA3ZYNF8fk_M13WtoBu228aLyeohtM3OhgnP4XGd2TXocXLZgQirFs8GNnEMOfBdOsB5e22cyIYUm6ASnzH_Pmv8y6EoJJVZWZCW9MG0NKEfv3fRjobbV6X63eVZsl3z_meBfsuxR_AYnjouM</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>873314675</pqid></control><display><type>article</type><title>Aborted germinal center reactions and B cell memory by follicular T cells specific for a B cell receptor V region peptide</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Alma/SFX Local Collection</source><creator>Heiser, Ryan A ; Snyder, Christopher M ; St Clair, James ; Wysocki, Lawrence J</creator><creatorcontrib>Heiser, Ryan A ; Snyder, Christopher M ; St Clair, James ; Wysocki, Lawrence J</creatorcontrib><description>A fundamental problem in immunoregulation is how CD4(+) T cells react to immunogenic peptides derived from the V region of the BCR that are created by somatic mechanisms, presented in MHC II, and amplified to abundance by B cell clonal expansion during immunity. BCR neo Ags open a potentially dangerous avenue of T cell help in violation of the principle of linked Ag recognition. To analyze this issue, we developed a murine adoptive transfer model using paired donor B cells and CD4 T cells specific for a BCR-derived peptide. BCR peptide-specific T cells aborted ongoing germinal center reactions and impeded the secondary immune response. Instead, they induced the B cells to differentiate into short-lived extrafollicular plasmablasts that secreted modest quantities of Ig. These results uncover an immunoregulatory process that restricts the memory pathway to B cells that communicate with CD4 T cells via exogenous foreign Ag.</description><identifier>ISSN: 0022-1767</identifier><identifier>EISSN: 1550-6606</identifier><identifier>DOI: 10.4049/jimmunol.1002328</identifier><identifier>PMID: 21622866</identifier><language>eng</language><publisher>United States</publisher><subject>Adoptive Transfer ; Amino Acid Sequence ; Animals ; Antigen Presentation - genetics ; Antigen Presentation - immunology ; B-Lymphocyte Subsets - immunology ; B-Lymphocyte Subsets - pathology ; B-Lymphocyte Subsets - transplantation ; CD4-Positive T-Lymphocytes - classification ; CD4-Positive T-Lymphocytes - immunology ; CD4-Positive T-Lymphocytes - pathology ; Cell Communication - genetics ; Cell Communication - immunology ; Epitopes, B-Lymphocyte - administration & dosage ; Epitopes, B-Lymphocyte - immunology ; Female ; Germinal Center - immunology ; Germinal Center - pathology ; Growth Inhibitors - administration & dosage ; Growth Inhibitors - genetics ; Growth Inhibitors - immunology ; Immunoglobulin kappa-Chains - genetics ; Immunoglobulin Variable Region - administration & dosage ; Immunoglobulin Variable Region - immunology ; Immunologic Memory - genetics ; Mice ; Mice, Inbred A ; Mice, Knockout ; Mice, Transgenic ; Molecular Sequence Data ; Peptides - administration & dosage ; Peptides - genetics ; Peptides - immunology ; Plasma Cells - immunology ; Plasma Cells - pathology ; Receptors, Antigen, B-Cell - administration & dosage ; Receptors, Antigen, B-Cell - immunology</subject><ispartof>The Journal of immunology (1950), 2011-07, Vol.187 (1), p.212-221</ispartof><rights>Copyright ©2011 by The American Association of Immunologists, Inc. 2011</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c427t-fb05a3a744634e8cf6a53cbe494b3a528053b13a2d0a0a76eee322199908b5923</citedby><cites>FETCH-LOGICAL-c427t-fb05a3a744634e8cf6a53cbe494b3a528053b13a2d0a0a76eee322199908b5923</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21622866$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Heiser, Ryan A</creatorcontrib><creatorcontrib>Snyder, Christopher M</creatorcontrib><creatorcontrib>St Clair, James</creatorcontrib><creatorcontrib>Wysocki, Lawrence J</creatorcontrib><title>Aborted germinal center reactions and B cell memory by follicular T cells specific for a B cell receptor V region peptide</title><title>The Journal of immunology (1950)</title><addtitle>J Immunol</addtitle><description>A fundamental problem in immunoregulation is how CD4(+) T cells react to immunogenic peptides derived from the V region of the BCR that are created by somatic mechanisms, presented in MHC II, and amplified to abundance by B cell clonal expansion during immunity. BCR neo Ags open a potentially dangerous avenue of T cell help in violation of the principle of linked Ag recognition. To analyze this issue, we developed a murine adoptive transfer model using paired donor B cells and CD4 T cells specific for a BCR-derived peptide. BCR peptide-specific T cells aborted ongoing germinal center reactions and impeded the secondary immune response. Instead, they induced the B cells to differentiate into short-lived extrafollicular plasmablasts that secreted modest quantities of Ig. These results uncover an immunoregulatory process that restricts the memory pathway to B cells that communicate with CD4 T cells via exogenous foreign Ag.</description><subject>Adoptive Transfer</subject><subject>Amino Acid Sequence</subject><subject>Animals</subject><subject>Antigen Presentation - genetics</subject><subject>Antigen Presentation - immunology</subject><subject>B-Lymphocyte Subsets - immunology</subject><subject>B-Lymphocyte Subsets - pathology</subject><subject>B-Lymphocyte Subsets - transplantation</subject><subject>CD4-Positive T-Lymphocytes - classification</subject><subject>CD4-Positive T-Lymphocytes - immunology</subject><subject>CD4-Positive T-Lymphocytes - pathology</subject><subject>Cell Communication - genetics</subject><subject>Cell Communication - immunology</subject><subject>Epitopes, B-Lymphocyte - administration & dosage</subject><subject>Epitopes, B-Lymphocyte - immunology</subject><subject>Female</subject><subject>Germinal Center - immunology</subject><subject>Germinal Center - pathology</subject><subject>Growth Inhibitors - administration & dosage</subject><subject>Growth Inhibitors - genetics</subject><subject>Growth Inhibitors - immunology</subject><subject>Immunoglobulin kappa-Chains - genetics</subject><subject>Immunoglobulin Variable Region - administration & dosage</subject><subject>Immunoglobulin Variable Region - immunology</subject><subject>Immunologic Memory - genetics</subject><subject>Mice</subject><subject>Mice, Inbred A</subject><subject>Mice, Knockout</subject><subject>Mice, Transgenic</subject><subject>Molecular Sequence Data</subject><subject>Peptides - administration & dosage</subject><subject>Peptides - genetics</subject><subject>Peptides - immunology</subject><subject>Plasma Cells - immunology</subject><subject>Plasma Cells - pathology</subject><subject>Receptors, Antigen, B-Cell - administration & dosage</subject><subject>Receptors, Antigen, B-Cell - immunology</subject><issn>0022-1767</issn><issn>1550-6606</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFUctO3DAUtaqiMtDuWVXedRW4fsRJNkgUlYeE1A2wtRznZjBy4tROkObv64EZRFdd2b7noXt8CDlhcCpBNmfPbhiWMfhTBsAFrz-RFStLKJQC9Zms8pAXrFLVITlK6RkAFHD5hRxypjivlVqRzUUb4owdXWMc3Gg8tTjOGGlEY2cXxkTN2NGfeew9HXAIcUPbDe2D984u3kR6_4olmia0rnc2Y5GavSSixWnOk8d8XWdDOuW36_ArOeiNT_htdx6Th6tf95c3xd3v69vLi7vCSl7NRd9CaYSppFRCYm17ZUphW5SNbIUpeQ2laJkwvAMDplKIKDhnTdNA3ZYNF8fk_M13WtoBu228aLyeohtM3OhgnP4XGd2TXocXLZgQirFs8GNnEMOfBdOsB5e22cyIYUm6ASnzH_Pmv8y6EoJJVZWZCW9MG0NKEfv3fRjobbV6X63eVZsl3z_meBfsuxR_AYnjouM</recordid><startdate>20110701</startdate><enddate>20110701</enddate><creator>Heiser, Ryan A</creator><creator>Snyder, Christopher M</creator><creator>St Clair, James</creator><creator>Wysocki, Lawrence J</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7T5</scope><scope>H94</scope><scope>5PM</scope></search><sort><creationdate>20110701</creationdate><title>Aborted germinal center reactions and B cell memory by follicular T cells specific for a B cell receptor V region peptide</title><author>Heiser, Ryan A ; Snyder, Christopher M ; St Clair, James ; Wysocki, Lawrence J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c427t-fb05a3a744634e8cf6a53cbe494b3a528053b13a2d0a0a76eee322199908b5923</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adoptive Transfer</topic><topic>Amino Acid Sequence</topic><topic>Animals</topic><topic>Antigen Presentation - genetics</topic><topic>Antigen Presentation - immunology</topic><topic>B-Lymphocyte Subsets - immunology</topic><topic>B-Lymphocyte Subsets - pathology</topic><topic>B-Lymphocyte Subsets - transplantation</topic><topic>CD4-Positive T-Lymphocytes - classification</topic><topic>CD4-Positive T-Lymphocytes - immunology</topic><topic>CD4-Positive T-Lymphocytes - pathology</topic><topic>Cell Communication - genetics</topic><topic>Cell Communication - immunology</topic><topic>Epitopes, B-Lymphocyte - administration & dosage</topic><topic>Epitopes, B-Lymphocyte - immunology</topic><topic>Female</topic><topic>Germinal Center - immunology</topic><topic>Germinal Center - pathology</topic><topic>Growth Inhibitors - administration & dosage</topic><topic>Growth Inhibitors - genetics</topic><topic>Growth Inhibitors - immunology</topic><topic>Immunoglobulin kappa-Chains - genetics</topic><topic>Immunoglobulin Variable Region - administration & dosage</topic><topic>Immunoglobulin Variable Region - immunology</topic><topic>Immunologic Memory - genetics</topic><topic>Mice</topic><topic>Mice, Inbred A</topic><topic>Mice, Knockout</topic><topic>Mice, Transgenic</topic><topic>Molecular Sequence Data</topic><topic>Peptides - administration & dosage</topic><topic>Peptides - genetics</topic><topic>Peptides - immunology</topic><topic>Plasma Cells - immunology</topic><topic>Plasma Cells - pathology</topic><topic>Receptors, Antigen, B-Cell - administration & dosage</topic><topic>Receptors, Antigen, B-Cell - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Heiser, Ryan A</creatorcontrib><creatorcontrib>Snyder, Christopher M</creatorcontrib><creatorcontrib>St Clair, James</creatorcontrib><creatorcontrib>Wysocki, Lawrence J</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The Journal of immunology (1950)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Heiser, Ryan A</au><au>Snyder, Christopher M</au><au>St Clair, James</au><au>Wysocki, Lawrence J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Aborted germinal center reactions and B cell memory by follicular T cells specific for a B cell receptor V region peptide</atitle><jtitle>The Journal of immunology (1950)</jtitle><addtitle>J Immunol</addtitle><date>2011-07-01</date><risdate>2011</risdate><volume>187</volume><issue>1</issue><spage>212</spage><epage>221</epage><pages>212-221</pages><issn>0022-1767</issn><eissn>1550-6606</eissn><abstract>A fundamental problem in immunoregulation is how CD4(+) T cells react to immunogenic peptides derived from the V region of the BCR that are created by somatic mechanisms, presented in MHC II, and amplified to abundance by B cell clonal expansion during immunity. BCR neo Ags open a potentially dangerous avenue of T cell help in violation of the principle of linked Ag recognition. To analyze this issue, we developed a murine adoptive transfer model using paired donor B cells and CD4 T cells specific for a BCR-derived peptide. BCR peptide-specific T cells aborted ongoing germinal center reactions and impeded the secondary immune response. Instead, they induced the B cells to differentiate into short-lived extrafollicular plasmablasts that secreted modest quantities of Ig. These results uncover an immunoregulatory process that restricts the memory pathway to B cells that communicate with CD4 T cells via exogenous foreign Ag.</abstract><cop>United States</cop><pmid>21622866</pmid><doi>10.4049/jimmunol.1002328</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0022-1767 |
| ispartof | The Journal of immunology (1950), 2011-07, Vol.187 (1), p.212-221 |
| issn | 0022-1767 1550-6606 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3133611 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Adoptive Transfer Amino Acid Sequence Animals Antigen Presentation - genetics Antigen Presentation - immunology B-Lymphocyte Subsets - immunology B-Lymphocyte Subsets - pathology B-Lymphocyte Subsets - transplantation CD4-Positive T-Lymphocytes - classification CD4-Positive T-Lymphocytes - immunology CD4-Positive T-Lymphocytes - pathology Cell Communication - genetics Cell Communication - immunology Epitopes, B-Lymphocyte - administration & dosage Epitopes, B-Lymphocyte - immunology Female Germinal Center - immunology Germinal Center - pathology Growth Inhibitors - administration & dosage Growth Inhibitors - genetics Growth Inhibitors - immunology Immunoglobulin kappa-Chains - genetics Immunoglobulin Variable Region - administration & dosage Immunoglobulin Variable Region - immunology Immunologic Memory - genetics Mice Mice, Inbred A Mice, Knockout Mice, Transgenic Molecular Sequence Data Peptides - administration & dosage Peptides - genetics Peptides - immunology Plasma Cells - immunology Plasma Cells - pathology Receptors, Antigen, B-Cell - administration & dosage Receptors, Antigen, B-Cell - immunology |
| title | Aborted germinal center reactions and B cell memory by follicular T cells specific for a B cell receptor V region peptide |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-01T20%3A54%3A23IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Aborted%20germinal%20center%20reactions%20and%20B%20cell%20memory%20by%20follicular%20T%20cells%20specific%20for%20a%20B%20cell%20receptor%20V%20region%20peptide&rft.jtitle=The%20Journal%20of%20immunology%20(1950)&rft.au=Heiser,%20Ryan%20A&rft.date=2011-07-01&rft.volume=187&rft.issue=1&rft.spage=212&rft.epage=221&rft.pages=212-221&rft.issn=0022-1767&rft.eissn=1550-6606&rft_id=info:doi/10.4049/jimmunol.1002328&rft_dat=%3Cproquest_pubme%3E904476729%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=873314675&rft_id=info:pmid/21622866&rfr_iscdi=true |