CHD8 suppresses p53-mediated apoptosis through histone H1 recruitment during early embryogenesis

The DNA-binding chromodomain helicase CHD8 regulates gene expression but how it acts on specific genes has been unclear. During early embryogenesis in mice, CHD8 recruits histone H1 to the p53-dependent promotors of apoptotic genes and thereby prevents massive cell death at this stage of development...

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Veröffentlicht in:	Nature cell biology 2009-02, Vol.11 (2), p.172-182
Hauptverfasser:	Nishiyama, Masaaki, Oshikawa, Kiyotaka, Tsukada, Yu-ichi, Nakagawa, Tadashi, Iemura, Shun-ichiro, Natsume, Tohru, Fan, Yuhong, Kikuchi, Akira, Skoultchi, Arthur I., Nakayama, Keiichi I.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Apoptosis - genetics Bioengineering Biology Biomedical and Life Sciences Cadherins - genetics Cancer Research Cell Biology Cell death Cell Line Cellular proteins Deoxyribonucleic acid Developmental Biology DNA DNA methylation Down-Regulation - genetics Embryonic development Embryonic Development - genetics Embryonic growth stage Embryos Enzymes Gene Expression Regulation, Developmental - genetics Gene mutations Genetic aspects HeLa Cells Histones - genetics Humans Life Sciences Macromolecular Substances - metabolism Mice Mice, Knockout Physiological aspects Protein Binding - genetics Proteins Repressor Proteins - genetics Repressor Proteins - metabolism Stem Cells Tumor Suppressor Protein p53 - genetics
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