p75 neurotrophin receptor mediates apoptosis in transit-amplifying cells and its overexpression restores cell death in psoriatic keratinocytes

p75 neurotrophin receptor (p75NTR) belongs to the TNF-receptor superfamily and signals apoptosis in many cell settings. In human epidermis, p75NTR is mostly confined to the transit-amplifying (TA) sub-population of basal keratinocytes. Brain-derived neurotrophic factor (BDNF) or neurotrophin-4 (NT-4...

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Veröffentlicht in:	Cell death and differentiation 2011-06, Vol.18 (6), p.948-958
Hauptverfasser:	Truzzi, F, Marconi, A, Atzei, P, Panza, M C, Lotti, R, Dallaglio, K, Tiberio, R, Palazzo, E, Vaschieri, C, Pincelli, C
Format:	Artikel
Sprache:	eng
Schlagworte:	631/80/82/23 631/80/86 692/699/2743/1313/1758 Adaptor Proteins, Vesicular Transport - genetics Adaptor Proteins, Vesicular Transport - metabolism Amyloid beta-Peptides Apoptosis Biochemistry Biomedical and Life Sciences Brain-derived neurotrophic factor Brain-Derived Neurotrophic Factor - genetics Brain-Derived Neurotrophic Factor - metabolism Caspase 3 - genetics Caspase 3 - metabolism Cell Biology Cell Cycle Analysis Cell death Cell Line Dermatology Enzyme Activation - genetics Growth factors Homeostasis Humans Keratinocytes - metabolism Keratinocytes - pathology Kinases Life Sciences Ligands Nervous system NF-kappa B - genetics NF-kappa B - metabolism Original Paper Phosphorylation Psoriasis Psoriasis - genetics Psoriasis - metabolism Receptor, Nerve Growth Factor - genetics Receptor, Nerve Growth Factor - metabolism Signal Transduction Stem Cells Tumor necrosis factor-TNF
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