Local insulin-like growth factor I expression is essential for Purkinje neuron survival at birth

IGF1, an anabolic and neuroprotective factor, promotes neuronal survival by blocking apoptosis. It is released into the bloodstream by the liver, or synthesized locally by muscles and neural cells, acting in an autocrine or paracrine fashion. Intriguingly, genetic studies conducted in invertebrate a...

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Veröffentlicht in:	Cell death and differentiation 2011-01, Vol.18 (1), p.48-59
Hauptverfasser:	Croci, L, Barili, V, Chia, D, Massimino, L, van Vugt, R, Masserdotti, G, Longhi, R, Rotwein, P, Consalez, G G
Format:	Artikel
Sprache:	eng
Schlagworte:	631/337/572 631/378/2571 631/45/612/1234 631/80/82/23 Animals Animals, Newborn Apoptosis Autophagy Basic Helix-Loop-Helix Transcription Factors - genetics Basic Helix-Loop-Helix Transcription Factors - metabolism Biochemistry Biomedical and Life Sciences Cell Biology Cell Cycle Analysis Cell death Cell Survival Cells, Cultured Cerebellum - metabolism Genes Insulin Insulin-Like Growth Factor I - genetics Insulin-Like Growth Factor I - metabolism Insulin-Like Growth Factor I - physiology Insulin-like growth factors Kinases Life Sciences Male Mice Mice, Inbred C57BL Mutation Neurons Neurosciences Original Paper Phosphatidylinositol 3-Kinases - metabolism Promoter Regions, Genetic Purkinje Cells - cytology Purkinje Cells - metabolism RNA Interference RNA, Small Interfering - metabolism Signal Transduction Stem Cells
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