Glucocorticoid-induced activation of caspase-8 protects the glucocorticoid-induced protein Gilz from proteasomal degradation and induces its binding to SUMO-1 in murine thymocytes

In this study, we evaluated the possible cross-talk between glucocorticoid (GC)-induced leucine zipper (Gilz) and caspase-8 in dexamethasone (Dex)-treated thymocytes. We determined that expression of Dex-induced Gilz protein was reduced when caspase-8 activity was inhibited, and this effect was not...

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Veröffentlicht in:	Cell death and differentiation 2011-01, Vol.18 (1), p.183-190
Hauptverfasser:	Delfino, D V, Spinicelli, S, Pozzesi, N, Pierangeli, S, Velardi, E, Bruscoli, S, Martelli, M P, Pettirossi, V, Falchi, L, Kang, T-b, Riccardi, C
Format:	Artikel
Sprache:	eng
Schlagworte:	631/250/1619/554 631/45/474/2085 631/80/458/538 631/80/82/23 Amino Acid Sequence Animals Antibodies - immunology Apoptosis Binding Sites Biochemistry Biomedical and Life Sciences Caspase 8 - genetics Caspase 8 - metabolism Caspase 8 - physiology Cell Biology Cell Cycle Analysis Cell death Cells, Cultured Chemotherapy Dexamethasone - pharmacology Enzymes Glucocorticoids - pharmacology Hematology Life Sciences Medicine Mice Molecular Sequence Data Original Paper Proteasome Endopeptidase Complex - metabolism Protein Binding Proteins Stem Cells SUMO-1 Protein - metabolism Sumoylation Thyroid Gland - cytology Thyroid Gland - metabolism Toxicology Transcription Factors - chemistry Transcription Factors - genetics Transcription Factors - metabolism Ubiquitin-Conjugating Enzymes - metabolism
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