G4 motifs correlate with promoter-proximal transcriptional pausing in human genes

The RNA Pol II transcription complex pauses just downstream of the promoter in a significant fraction of human genes. The local features of genomic structure that contribute to pausing have not been defined. Here, we show that genes that pause are more G-rich within the region flanking the transcrip...

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Veröffentlicht in:	Nucleic acids research 2011-07, Vol.39 (12), p.4975-4983
Hauptverfasser:	Eddy, Johanna, Vallur, Aarthy C., Varma, Sudir, Liu, Hongfang, Reinhold, William C., Pommier, Yves, Maizels, Nancy
Format:	Artikel
Sprache:	eng
Schlagworte:	Binding Sites Cell Line, Tumor CpG Islands Gene Regulation, Chromatin and Epigenetics Guanine - analysis Heterogeneous-Nuclear Ribonucleoproteins - metabolism Humans Introns Promoter Regions, Genetic Regulatory Elements, Transcriptional RNA Polymerase II - metabolism Transcription Factors - metabolism Transcription Initiation Site Transcription, Genetic
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