Diet-induced obesity leads to the development of leptin resistance in vagal afferent neurons

Ingestion of high-fat, high-calorie diets is associated with hyperphagia, increased body fat, and obesity. The mechanisms responsible are currently unclear; however, altered leptin signaling may be an important factor. Vagal afferent neurons (VAN) integrate signals from the gut in response to ingest...

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Veröffentlicht in:	American journal of physiology: endocrinology and metabolism 2011-07, Vol.301 (1), p.E187-E195
Hauptverfasser:	de Lartigue, Guillaume, Barbier de la Serre, Claire, Espero, Elvis, Lee, Jennifer, Raybould, Helen E
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Body Weight - drug effects Diet - adverse effects Diet, Atherogenic Dietary Fats - pharmacology Drug Resistance - drug effects Drug Resistance - physiology Energy Intake - drug effects Energy Intake - physiology Gene expression Leptin - metabolism Leptin - pharmacology Lipopolysaccharides - pharmacology Neurons Neurons, Afferent - drug effects Neurons, Afferent - metabolism Neurons, Afferent - pathology Obesity - complications Obesity - etiology Obesity - metabolism Obesity - pathology Proteins Rats Rats, Sprague-Dawley Receptors, Leptin - metabolism Rodents Suppressor of Cytokine Signaling 3 Protein Suppressor of Cytokine Signaling Proteins - metabolism Suppressor of Cytokine Signaling Proteins - physiology Vagus Nerve - drug effects Vagus Nerve - metabolism Vagus Nerve - pathology Vagus Nerve Diseases - etiology Vagus Nerve Diseases - metabolism
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