Development of a Liver-specific Tet-On Inducible System for AAV Vectors and Its Application in the Treatment of Liver Cancer

Recombinant adeno-associated virus (rAAV) are effective gene delivery vehicles that can mediate long-lasting transgene expression. However, tight regulation and tissue-specific transgene expression is required for certain therapeutic applications. For regulatable expression from the liver we designe...

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Veröffentlicht in:	Molecular therapy 2011-07, Vol.19 (7), p.1245-1253
Hauptverfasser:	Vanrell, Lucia, Di Scala, Marianna, Blanco, Laura, Otano, Itziar, Gil-Farina, Irene, Baldim, Victor, Paneda, Astrid, Berraondo, Pedro, Beattie, Stuart G, Chtarto, Abdelwahed, Tenenbaum, Lilianne, Prieto, Jesús, Gonzalez-Aseguinolaza, Gloria
Format:	Artikel
Sprache:	eng
Schlagworte:	Adeno-associated virus Alanine Transaminase - blood Animals Aspartate Aminotransferases Cell Line Dependovirus - genetics Doxycycline - pharmacology Female Flow Cytometry Gene Expression Regulation, Neoplastic - drug effects Genetic Therapy - methods Genetic Vectors - genetics HEK293 Cells HeLa Cells Hep G2 Cells Humans Interferon-gamma Interleukin-12 - genetics Interleukin-12 - metabolism Liver cancer Liver Neoplasms - genetics Liver Neoplasms - metabolism Liver Neoplasms - therapy Male Mice Mice, Inbred BALB C Original Tetracycline - pharmacology
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