Antitumor activity of mutant bacterial cytosine deaminase gene for colon cancer

AIM： To evaluate bacterial cytosine deaminase （bCD） mutant D314A and 5-fluorocytosine （5-FC） for treatment of colon cancer in a mouse model. METHODS： Recombinant lentivirus vectors that contained wild-type bCD gene （bCDwt）, and bCD mutant D314A gene （bCD-D314A） with green fluorescence protein gene w...

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Veröffentlicht in:	World journal of gastroenterology : WJG 2011-06, Vol.17 (24), p.2958-2964
Hauptverfasser:	Deng, Long-Ying, Wang, Jian-Ping, Gui, Zhi-Fu, Shen, Li-Zong
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antimetabolites - therapeutic use Bacterial Proteins - genetics Bacterial Proteins - metabolism Bacterial Proteins - therapeutic use Brief Cell Line, Tumor Colonic Neoplasms - drug therapy Colonic Neoplasms - genetics Cytosine Deaminase - genetics Cytosine Deaminase - metabolism Cytosine Deaminase - therapeutic use Female Flucytosine - therapeutic use Gene Transfer Techniques Genes, Transgenic, Suicide Genetic Therapy - methods Humans Mice Mice, Inbred BALB C Mice, Nude Neoplasm Transplantation Sequence Analysis, DNA Transplantation, Heterologous 慢病毒载体抗肿瘤活性突变细菌结肠癌绿色荧光蛋白基因胞嘧啶脱氨酶酶基因
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