MicroRNA Sequence and Expression Analysis in Breast Tumors by Deep Sequencing

MicroRNAs (miRNA) regulate many genes critical for tumorigenesis. We profiled miRNAs from 11 normal breast tissues, 17 noninvasive, 151 invasive breast carcinomas, and 6 cell lines by in-house-developed barcoded Solexa sequencing. miRNAs were organized in genomic clusters representing promoter-contr...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2011-07, Vol.71 (13), p.4443-4453
Hauptverfasser:	FARAZI, Thalia A, HORLINGS, Hugo M, KREIKE, Bas, SIE, Daoud, HOVESTADT, Volker, WESSELS, Lodewyk F. A, VAN DE VIJVER, Marc J, TUSCHL, Thomas, TEN HOEVE, Jelle J, MIHAILOVIC, Aleksandra, HALFWERK, Hans, MOROZOV, Pavel, BROWN, Miguel, HAFNER, Markus, REYAL, Fabien, VAN KOUWENHOVE, Marieke
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic agents Biological and medical sciences Breast carcinoma Breast Neoplasms - genetics Breast Neoplasms - metabolism Breast Neoplasms - pathology Carcinoma, Ductal, Breast - genetics Carcinoma, Ductal, Breast - metabolism Carcinoma, Ductal, Breast - pathology Cell Line, Tumor Cluster Analysis Differentiation DNA, Complementary - genetics Female Gene expression Gene Expression Profiling genomics Gynecology. Andrology. Obstetrics Humans Invasiveness Mammary gland diseases Medical sciences Metastases MicroRNAs - genetics miRNA Neoplasm Invasiveness Nucleotides Pharmacology. Drug treatments Polymorphism, Single Nucleotide Receptor, ErbB-2 - biosynthesis Receptors, Estrogen - biosynthesis Receptors, Progesterone - biosynthesis Tumor suppressor genes Tumorigenesis Tumors
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