Individual Differences in Subconscious Motor Control Predicted by GABA Concentration in SMA
Subliminal visual stimuli affect motor planning [ 1], but the size of such effects differs greatly between individuals [ 2, 3]. Here, we investigated whether such variation may be related to neurochemical differences between people. Cortical responsiveness is expected to be lower under the influence...
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| creator | Boy, Frederic Evans, C. John Edden, Richard A.E. Singh, Krish D. Husain, Masud Sumner, Petroc |
| description | Subliminal visual stimuli affect motor planning [
1], but the size of such effects differs greatly between individuals [
2, 3]. Here, we investigated whether such variation may be related to neurochemical differences between people. Cortical responsiveness is expected to be lower under the influence of more of the main inhibitory neurotransmitter, GABA [
4]. Thus, we hypothesized that, if an individual has more GABA in the supplementary motor area (SMA)—a region previously associated with automatic motor control [
5]—this would result in smaller subliminal effects. We measured the reversed masked prime—or negative compatibility—effect, and found that it correlated strongly with GABA concentration, measured with magnetic resonance spectroscopy. This occurred specifically in the SMA region, and not in other regions from which spectroscopy measurements were taken. We replicated these results in an independent cohort: more GABA in the SMA region is reliably associated with smaller effect size. These findings suggest that, across individuals, the responsiveness of subconscious motor mechanisms is related to GABA concentration in the SMA.
[Display omitted]
► Reversed masked priming correlates with GABA concentration in SMA ► GABA measured in other sensorimotor control regions does not correlate with priming |
| doi_str_mv | 10.1016/j.cub.2010.09.003 |
| format | Article |
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1], but the size of such effects differs greatly between individuals [
2, 3]. Here, we investigated whether such variation may be related to neurochemical differences between people. Cortical responsiveness is expected to be lower under the influence of more of the main inhibitory neurotransmitter, GABA [
4]. Thus, we hypothesized that, if an individual has more GABA in the supplementary motor area (SMA)—a region previously associated with automatic motor control [
5]—this would result in smaller subliminal effects. We measured the reversed masked prime—or negative compatibility—effect, and found that it correlated strongly with GABA concentration, measured with magnetic resonance spectroscopy. This occurred specifically in the SMA region, and not in other regions from which spectroscopy measurements were taken. We replicated these results in an independent cohort: more GABA in the SMA region is reliably associated with smaller effect size. These findings suggest that, across individuals, the responsiveness of subconscious motor mechanisms is related to GABA concentration in the SMA.
[Display omitted]
► Reversed masked priming correlates with GABA concentration in SMA ► GABA measured in other sensorimotor control regions does not correlate with priming</description><identifier>ISSN: 0960-9822</identifier><identifier>ISSN: 1879-0445</identifier><identifier>EISSN: 1879-0445</identifier><identifier>DOI: 10.1016/j.cub.2010.09.003</identifier><identifier>PMID: 20888227</identifier><language>eng</language><publisher>England: Elsevier Inc</publisher><subject>Adult ; Brain Mapping - methods ; gamma-Aminobutyric Acid - metabolism ; Humans ; Individuality ; Magnetic Resonance Imaging ; Magnetic resonance spectroscopy ; Male ; Motor Cortex - anatomy & histology ; Motor Cortex - physiology ; Movement - physiology ; Neuropsychological Tests ; Unconscious, Psychology ; Young Adult</subject><ispartof>Current biology, 2010-10, Vol.20 (19), p.1779-1785</ispartof><rights>2010 Elsevier Ltd</rights><rights>Copyright © 2010 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c482t-1cc80e46c83ed7c9ae7a7d11e836bdbbc4c61b8b766fe8a29fe8f5c95a2b8c543</citedby><cites>FETCH-LOGICAL-c482t-1cc80e46c83ed7c9ae7a7d11e836bdbbc4c61b8b766fe8a29fe8f5c95a2b8c543</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.cub.2010.09.003$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>230,314,778,782,883,3539,27911,27912,45982</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20888227$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Boy, Frederic</creatorcontrib><creatorcontrib>Evans, C. John</creatorcontrib><creatorcontrib>Edden, Richard A.E.</creatorcontrib><creatorcontrib>Singh, Krish D.</creatorcontrib><creatorcontrib>Husain, Masud</creatorcontrib><creatorcontrib>Sumner, Petroc</creatorcontrib><title>Individual Differences in Subconscious Motor Control Predicted by GABA Concentration in SMA</title><title>Current biology</title><addtitle>Curr Biol</addtitle><description>Subliminal visual stimuli affect motor planning [
1], but the size of such effects differs greatly between individuals [
2, 3]. Here, we investigated whether such variation may be related to neurochemical differences between people. Cortical responsiveness is expected to be lower under the influence of more of the main inhibitory neurotransmitter, GABA [
4]. Thus, we hypothesized that, if an individual has more GABA in the supplementary motor area (SMA)—a region previously associated with automatic motor control [
5]—this would result in smaller subliminal effects. We measured the reversed masked prime—or negative compatibility—effect, and found that it correlated strongly with GABA concentration, measured with magnetic resonance spectroscopy. This occurred specifically in the SMA region, and not in other regions from which spectroscopy measurements were taken. We replicated these results in an independent cohort: more GABA in the SMA region is reliably associated with smaller effect size. These findings suggest that, across individuals, the responsiveness of subconscious motor mechanisms is related to GABA concentration in the SMA.
[Display omitted]
► Reversed masked priming correlates with GABA concentration in SMA ► GABA measured in other sensorimotor control regions does not correlate with priming</description><subject>Adult</subject><subject>Brain Mapping - methods</subject><subject>gamma-Aminobutyric Acid - metabolism</subject><subject>Humans</subject><subject>Individuality</subject><subject>Magnetic Resonance Imaging</subject><subject>Magnetic resonance spectroscopy</subject><subject>Male</subject><subject>Motor Cortex - anatomy & histology</subject><subject>Motor Cortex - physiology</subject><subject>Movement - physiology</subject><subject>Neuropsychological Tests</subject><subject>Unconscious, Psychology</subject><subject>Young Adult</subject><issn>0960-9822</issn><issn>1879-0445</issn><issn>1879-0445</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU9v1DAQxS0EotvCB-CCcuOUxXYS_xES0rKUUqkVSMCJg2WPJ-BVNi52slK_PQ5bKrjAxZb93jzNzI-QZ4yuGWXi5W4Ns1tzWt5UryltHpAVU1LXtG27h2RFtaC1VpyfkNOcd5QyrrR4TE44Vap8yxX5ejn6cAh-tkP1NvQ9JhwBcxXG6tPsII4ZQpxzdR2nmKptHKcUh-pjQh9gQl-52-pi82azKIBFtFOI46_q680T8qi3Q8and_cZ-fLu_PP2fX314eJyu7mqoVV8qhmAotgKUA16CdqitNIzhqoRzjsHLQjmlJNC9Kgs1-XsO9Cd5U5B1zZn5PUx92Z2e_THPgZzk8LeplsTbTB_K2P4br7Fg2mWfShRAl7cBaT4Y8Y8mX3IgMNgRyzDG82FUrQR3X-dspNSd7RZnOzohBRzTtjf98OoWeiZnSn0zELPUG0KvVLz_M9B7it-4yqGV0cDlnUeAiZT8CzAfEgIk_Ex_CP-JyAArIE</recordid><startdate>20101012</startdate><enddate>20101012</enddate><creator>Boy, Frederic</creator><creator>Evans, C. John</creator><creator>Edden, Richard A.E.</creator><creator>Singh, Krish D.</creator><creator>Husain, Masud</creator><creator>Sumner, Petroc</creator><general>Elsevier Inc</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7TK</scope><scope>5PM</scope></search><sort><creationdate>20101012</creationdate><title>Individual Differences in Subconscious Motor Control Predicted by GABA Concentration in SMA</title><author>Boy, Frederic ; Evans, C. John ; Edden, Richard A.E. ; Singh, Krish D. ; Husain, Masud ; Sumner, Petroc</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c482t-1cc80e46c83ed7c9ae7a7d11e836bdbbc4c61b8b766fe8a29fe8f5c95a2b8c543</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Adult</topic><topic>Brain Mapping - methods</topic><topic>gamma-Aminobutyric Acid - metabolism</topic><topic>Humans</topic><topic>Individuality</topic><topic>Magnetic Resonance Imaging</topic><topic>Magnetic resonance spectroscopy</topic><topic>Male</topic><topic>Motor Cortex - anatomy & histology</topic><topic>Motor Cortex - physiology</topic><topic>Movement - physiology</topic><topic>Neuropsychological Tests</topic><topic>Unconscious, Psychology</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Boy, Frederic</creatorcontrib><creatorcontrib>Evans, C. John</creatorcontrib><creatorcontrib>Edden, Richard A.E.</creatorcontrib><creatorcontrib>Singh, Krish D.</creatorcontrib><creatorcontrib>Husain, Masud</creatorcontrib><creatorcontrib>Sumner, Petroc</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Neurosciences Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Current biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Boy, Frederic</au><au>Evans, C. John</au><au>Edden, Richard A.E.</au><au>Singh, Krish D.</au><au>Husain, Masud</au><au>Sumner, Petroc</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Individual Differences in Subconscious Motor Control Predicted by GABA Concentration in SMA</atitle><jtitle>Current biology</jtitle><addtitle>Curr Biol</addtitle><date>2010-10-12</date><risdate>2010</risdate><volume>20</volume><issue>19</issue><spage>1779</spage><epage>1785</epage><pages>1779-1785</pages><issn>0960-9822</issn><issn>1879-0445</issn><eissn>1879-0445</eissn><abstract>Subliminal visual stimuli affect motor planning [
1], but the size of such effects differs greatly between individuals [
2, 3]. Here, we investigated whether such variation may be related to neurochemical differences between people. Cortical responsiveness is expected to be lower under the influence of more of the main inhibitory neurotransmitter, GABA [
4]. Thus, we hypothesized that, if an individual has more GABA in the supplementary motor area (SMA)—a region previously associated with automatic motor control [
5]—this would result in smaller subliminal effects. We measured the reversed masked prime—or negative compatibility—effect, and found that it correlated strongly with GABA concentration, measured with magnetic resonance spectroscopy. This occurred specifically in the SMA region, and not in other regions from which spectroscopy measurements were taken. We replicated these results in an independent cohort: more GABA in the SMA region is reliably associated with smaller effect size. These findings suggest that, across individuals, the responsiveness of subconscious motor mechanisms is related to GABA concentration in the SMA.
[Display omitted]
► Reversed masked priming correlates with GABA concentration in SMA ► GABA measured in other sensorimotor control regions does not correlate with priming</abstract><cop>England</cop><pub>Elsevier Inc</pub><pmid>20888227</pmid><doi>10.1016/j.cub.2010.09.003</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Cell Press Free Archives; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; ScienceDirect Journals (5 years ago - present) |
| subjects | Adult Brain Mapping - methods gamma-Aminobutyric Acid - metabolism Humans Individuality Magnetic Resonance Imaging Magnetic resonance spectroscopy Male Motor Cortex - anatomy & histology Motor Cortex - physiology Movement - physiology Neuropsychological Tests Unconscious, Psychology Young Adult |
| title | Individual Differences in Subconscious Motor Control Predicted by GABA Concentration in SMA |
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