Toxoplasma gondii Hsp70 as a danger signal in Toxoplasma gondii-infected mice
Toxoplasma gondii Hsp70, T gondii Hsp30/bag1, and surface antigen 1 messenger RNAs were shown to be useful in analyzing stage conversion of T gondii between bradyzoites and tachyzoites. The high-level expression of T gondii Hsp70 was correlated with mortality in interferon-γ knockout mice infected w...
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| Veröffentlicht in: | Cell stress & chaperones 2000-10, Vol.5 (4), p.328-335 |
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| container_title | Cell stress & chaperones |
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| creator | Mun, Hye-Seong Aosai, Fumie Norose, Kazumi Chen, Mei Hata, Hidekazu Tagawa, Yoh-ichi Iwakura, Yoichi Byun, Dae-Seok Yano, Akihiko |
| description | Toxoplasma gondii Hsp70, T gondii Hsp30/bag1, and surface antigen 1 messenger RNAs were shown to be useful in analyzing stage conversion of T gondii between bradyzoites and tachyzoites. The high-level expression of T gondii Hsp70 was correlated with mortality in interferon-γ knockout mice infected with T gondii. T gondii Hsp70 inhibited the induction of nitric oxide release by peritoneal macrophages of T gondii-infected mice. These findings identify T gondii Hsp70 as a danger signal during lethal, acute T gondii infection. |
| doi_str_mv | 10.1379/1466-1268(2000)005<0328:TGHAAD>2.0.CO;2 |
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The high-level expression of T gondii Hsp70 was correlated with mortality in interferon-γ knockout mice infected with T gondii. T gondii Hsp70 inhibited the induction of nitric oxide release by peritoneal macrophages of T gondii-infected mice. These findings identify T gondii Hsp70 as a danger signal during lethal, acute T gondii infection.</description><identifier>ISSN: 1355-8145</identifier><identifier>EISSN: 1466-1268</identifier><identifier>DOI: 10.1379/1466-1268(2000)005<0328:TGHAAD>2.0.CO;2</identifier><identifier>PMID: 11048655</identifier><language>eng</language><publisher>Netherlands: Cell Stress Society International</publisher><subject><![CDATA[Animals ; Antigens, Protozoan ; Bradyzoites ; Cysts ; Heat-Shock Proteins - genetics ; Heat-Shock Proteins - isolation & purification ; HSP30 Heat-Shock Proteins ; HSP70 Heat-Shock Proteins - isolation & purification ; Immunity ; Immunity, Innate ; Infections ; Interferon-gamma - genetics ; Interferon-gamma - pharmacology ; Macrophages, Peritoneal - metabolism ; Membrane Proteins - genetics ; Membrane Proteins - isolation & purification ; Messenger RNA ; Mice ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Mice, Knockout ; Nitric Oxide - metabolism ; Original ; Original s ; Peritoneal macrophages ; Protozoan Proteins - genetics ; Protozoan Proteins - isolation & purification ; Reverse transcriptase polymerase chain reaction ; RNA, Messenger - isolation & purification ; RNA, Protozoan - isolation & purification ; T lymphocytes ; Tachyzoites ; Toxoplasmosis, Animal - mortality]]></subject><ispartof>Cell stress & chaperones, 2000-10, Vol.5 (4), p.328-335</ispartof><rights>Cell Stress Society International</rights><rights>Copyright 2000 Cell Stress Society International</rights><rights>Copyright © 2000, Cell Stress Society International 2000</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-b3882-15c22e89a73e10bdf58e7343273617dc0e1778c633ce0b37b625d01d968551b63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://bioone.org/doi/pdf/10.1379/1466-1268(2000)005<0328:TGHAAD>2.0.CO;2$$EPDF$$P50$$Gbioone$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/1601822$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,314,724,777,781,800,882,26959,27905,27906,52344,53772,53774,57998,58231</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11048655$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mun, Hye-Seong</creatorcontrib><creatorcontrib>Aosai, Fumie</creatorcontrib><creatorcontrib>Norose, Kazumi</creatorcontrib><creatorcontrib>Chen, Mei</creatorcontrib><creatorcontrib>Hata, Hidekazu</creatorcontrib><creatorcontrib>Tagawa, Yoh-ichi</creatorcontrib><creatorcontrib>Iwakura, Yoichi</creatorcontrib><creatorcontrib>Byun, Dae-Seok</creatorcontrib><creatorcontrib>Yano, Akihiko</creatorcontrib><title>Toxoplasma gondii Hsp70 as a danger signal in Toxoplasma gondii-infected mice</title><title>Cell stress & chaperones</title><addtitle>Cell Stress Chaperones</addtitle><description>Toxoplasma gondii Hsp70, T gondii Hsp30/bag1, and surface antigen 1 messenger RNAs were shown to be useful in analyzing stage conversion of T gondii between bradyzoites and tachyzoites. The high-level expression of T gondii Hsp70 was correlated with mortality in interferon-γ knockout mice infected with T gondii. T gondii Hsp70 inhibited the induction of nitric oxide release by peritoneal macrophages of T gondii-infected mice. These findings identify T gondii Hsp70 as a danger signal during lethal, acute T gondii infection.</description><subject>Animals</subject><subject>Antigens, Protozoan</subject><subject>Bradyzoites</subject><subject>Cysts</subject><subject>Heat-Shock Proteins - genetics</subject><subject>Heat-Shock Proteins - isolation & purification</subject><subject>HSP30 Heat-Shock Proteins</subject><subject>HSP70 Heat-Shock Proteins - isolation & purification</subject><subject>Immunity</subject><subject>Immunity, Innate</subject><subject>Infections</subject><subject>Interferon-gamma - genetics</subject><subject>Interferon-gamma - pharmacology</subject><subject>Macrophages, Peritoneal - metabolism</subject><subject>Membrane Proteins - genetics</subject><subject>Membrane Proteins - isolation & purification</subject><subject>Messenger RNA</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Mice, Inbred C57BL</subject><subject>Mice, Knockout</subject><subject>Nitric Oxide - metabolism</subject><subject>Original</subject><subject>Original s</subject><subject>Peritoneal macrophages</subject><subject>Protozoan Proteins - genetics</subject><subject>Protozoan Proteins - isolation & purification</subject><subject>Reverse transcriptase polymerase chain reaction</subject><subject>RNA, Messenger - isolation & purification</subject><subject>RNA, Protozoan - isolation & purification</subject><subject>T lymphocytes</subject><subject>Tachyzoites</subject><subject>Toxoplasmosis, Animal - mortality</subject><issn>1355-8145</issn><issn>1466-1268</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqdkU1vEzEQhi0EoqXwDxDyCZXDpmM7_lgolaLQJkhFuYTzyOt1gqtdO6wTVP49u9qoBfXGyZbmeWdG8xBywWDChC4v2FSpgnFlzjkAfACQlyC4-bheLGezL1d8ApP56hN_Rk4fyOf9X0hZGDaVJ-RVznd9UmvNXpITxmBqlJSn5Ns63addY3Nr6TbFOgS6zDsN1GZqaW3j1nc0h220DQ2RPqGLEDfe7X1N2-D8a_JiY5vs3xzfM_L95no9Xxa3q8XX-ey2qIQxvGDSce5NabXwDKp6I43XYiq4Forp2oFnWhunhHAeKqErxWUNrC6VkZJVSpyRz2Pf3aFqfe183He2wV0XWtv9xmQD_luJ4Qdu0y8UjBvF-_z7Y75LPw8-77EN2fmmsdGnQ0bNhSyVLHtwMYKuSzl3fvMwgwEOZnC4Nw73xsEM9mZwMIOjGeQIOF_hMPLd3ys_9jmq6IG3I3CX96l7rCtghg_567FchZSi_-89_gD79qop</recordid><startdate>20001001</startdate><enddate>20001001</enddate><creator>Mun, Hye-Seong</creator><creator>Aosai, Fumie</creator><creator>Norose, Kazumi</creator><creator>Chen, Mei</creator><creator>Hata, Hidekazu</creator><creator>Tagawa, Yoh-ichi</creator><creator>Iwakura, Yoichi</creator><creator>Byun, Dae-Seok</creator><creator>Yano, Akihiko</creator><general>Cell Stress Society International</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20001001</creationdate><title>Toxoplasma gondii Hsp70 as a danger signal in Toxoplasma gondii-infected mice</title><author>Mun, Hye-Seong ; Aosai, Fumie ; Norose, Kazumi ; Chen, Mei ; Hata, Hidekazu ; Tagawa, Yoh-ichi ; Iwakura, Yoichi ; Byun, Dae-Seok ; Yano, Akihiko</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b3882-15c22e89a73e10bdf58e7343273617dc0e1778c633ce0b37b625d01d968551b63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Animals</topic><topic>Antigens, Protozoan</topic><topic>Bradyzoites</topic><topic>Cysts</topic><topic>Heat-Shock Proteins - genetics</topic><topic>Heat-Shock Proteins - isolation & purification</topic><topic>HSP30 Heat-Shock Proteins</topic><topic>HSP70 Heat-Shock Proteins - isolation & purification</topic><topic>Immunity</topic><topic>Immunity, Innate</topic><topic>Infections</topic><topic>Interferon-gamma - genetics</topic><topic>Interferon-gamma - pharmacology</topic><topic>Macrophages, Peritoneal - metabolism</topic><topic>Membrane Proteins - genetics</topic><topic>Membrane Proteins - isolation & purification</topic><topic>Messenger RNA</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Mice, Inbred C57BL</topic><topic>Mice, Knockout</topic><topic>Nitric Oxide - metabolism</topic><topic>Original</topic><topic>Original s</topic><topic>Peritoneal macrophages</topic><topic>Protozoan Proteins - genetics</topic><topic>Protozoan Proteins - isolation & purification</topic><topic>Reverse transcriptase polymerase chain reaction</topic><topic>RNA, Messenger - isolation & purification</topic><topic>RNA, Protozoan - isolation & purification</topic><topic>T lymphocytes</topic><topic>Tachyzoites</topic><topic>Toxoplasmosis, Animal - mortality</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mun, Hye-Seong</creatorcontrib><creatorcontrib>Aosai, Fumie</creatorcontrib><creatorcontrib>Norose, Kazumi</creatorcontrib><creatorcontrib>Chen, Mei</creatorcontrib><creatorcontrib>Hata, Hidekazu</creatorcontrib><creatorcontrib>Tagawa, Yoh-ichi</creatorcontrib><creatorcontrib>Iwakura, Yoichi</creatorcontrib><creatorcontrib>Byun, Dae-Seok</creatorcontrib><creatorcontrib>Yano, Akihiko</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Cell stress & chaperones</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mun, Hye-Seong</au><au>Aosai, Fumie</au><au>Norose, Kazumi</au><au>Chen, Mei</au><au>Hata, Hidekazu</au><au>Tagawa, Yoh-ichi</au><au>Iwakura, Yoichi</au><au>Byun, Dae-Seok</au><au>Yano, Akihiko</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Toxoplasma gondii Hsp70 as a danger signal in Toxoplasma gondii-infected mice</atitle><jtitle>Cell stress & chaperones</jtitle><addtitle>Cell Stress Chaperones</addtitle><date>2000-10-01</date><risdate>2000</risdate><volume>5</volume><issue>4</issue><spage>328</spage><epage>335</epage><pages>328-335</pages><issn>1355-8145</issn><eissn>1466-1268</eissn><abstract>Toxoplasma gondii Hsp70, T gondii Hsp30/bag1, and surface antigen 1 messenger RNAs were shown to be useful in analyzing stage conversion of T gondii between bradyzoites and tachyzoites. The high-level expression of T gondii Hsp70 was correlated with mortality in interferon-γ knockout mice infected with T gondii. T gondii Hsp70 inhibited the induction of nitric oxide release by peritoneal macrophages of T gondii-infected mice. These findings identify T gondii Hsp70 as a danger signal during lethal, acute T gondii infection.</abstract><cop>Netherlands</cop><pub>Cell Stress Society International</pub><pmid>11048655</pmid><doi>10.1379/1466-1268(2000)005<0328:TGHAAD>2.0.CO;2</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Cell stress & chaperones, 2000-10, Vol.5 (4), p.328-335 |
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| source | MEDLINE; SpringerLink Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; BioOne Complete; Jstor Complete Legacy; PubMed Central; Alma/SFX Local Collection |
| subjects | Animals Antigens, Protozoan Bradyzoites Cysts Heat-Shock Proteins - genetics Heat-Shock Proteins - isolation & purification HSP30 Heat-Shock Proteins HSP70 Heat-Shock Proteins - isolation & purification Immunity Immunity, Innate Infections Interferon-gamma - genetics Interferon-gamma - pharmacology Macrophages, Peritoneal - metabolism Membrane Proteins - genetics Membrane Proteins - isolation & purification Messenger RNA Mice Mice, Inbred BALB C Mice, Inbred C57BL Mice, Knockout Nitric Oxide - metabolism Original Original s Peritoneal macrophages Protozoan Proteins - genetics Protozoan Proteins - isolation & purification Reverse transcriptase polymerase chain reaction RNA, Messenger - isolation & purification RNA, Protozoan - isolation & purification T lymphocytes Tachyzoites Toxoplasmosis, Animal - mortality |
| title | Toxoplasma gondii Hsp70 as a danger signal in Toxoplasma gondii-infected mice |
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