Detection of a secreted metalloprotease within the nuclei of liver cells

ADAMTS13 is a secreted zinc metalloprotease expressed by various cell types. Here, we investigate its cellular pathway in endogenously expressing liver cell lines and after transient transfection with ADAMTS13. Besides compartmentalizations of the cellular secretory system, we detected an appreciabl...

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Veröffentlicht in:	Molecular bioSystems 2011-06, Vol.7 (6), p.2012-2018
Hauptverfasser:	Hunt, Ryan C, Geetha, S, Allen, Courtni E, Hershko, Klilah, Fathke, Robert, Kong, Philip L, Plum, Elizabeth, Struble, Evi Budo, Soejima, Kenji, Friedman, Scott, Garfield, Susan, Balaji, S, Kimchi-Sarfaty, Chava
Format:	Artikel
Sprache:	eng
Schlagworte:	ADAM Proteins - metabolism ADAMTS13 Protein Amino Acid Sequence Cell Line Cell Nucleus - metabolism Conserved Sequence Hepatocytes - metabolism Humans Models, Molecular Protein Interaction Domains and Motifs Protein Sorting Signals Protein Structure, Secondary Sequence Analysis, Protein
Online-Zugang:	Volltext
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