Biomarkers of folate status in NHANES: a roundtable summary
A roundtable to discuss the measurement of folate status biomarkers in NHANES took place in July 2010. NHANES has measured serum folate since 1974 and red blood cell (RBC) folate since 1978 with the use of several different measurement procedures. Data on serum 5-methyltetrahydrofolate (5MTHF) and f...
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| creator | YETLEY, Elizabeth A PFEIFFER, Christine M RANDY CURTIN, L DURAZO-ARVIZU, Ramón A ECKFELDT, John H GREEN, Ralph GREGORY, Jesse F HOOFNAGLE, Andrew N JACOBSEN, Donald W JACQUES, Paul F MOLLOY, Anne M MASSARO, Joseph PHINNEY, Karen W MILLS, James L NEXO, Ebba RADER, Jeanne I SELHUB, Jacob SEMPOS, Christopher SHANE, Barry PATRICK STOVER, Sally Stabler TAMURA, Tsunenobu TEDSTONE, Alison THORPE, Susan J FAZILI, Zia COATES, Paul M JOHNSON, Clifford L PICCIANO, Mary Frances LACHER, David A BAILEY, Regan L BLACKMORE, Sheena BOCK, Jay L BRODY, Lawrence C CARMEL, Ralph |
| description | A roundtable to discuss the measurement of folate status biomarkers in NHANES took place in July 2010. NHANES has measured serum folate since 1974 and red blood cell (RBC) folate since 1978 with the use of several different measurement procedures. Data on serum 5-methyltetrahydrofolate (5MTHF) and folic acid (FA) concentrations in persons aged ≥60 y are available in NHANES 1999-2002. The roundtable reviewed data that showed that folate concentrations from the Bio-Rad Quantaphase II procedure (Bio-Rad Laboratories, Hercules, CA; used in NHANES 1991-1994 and NHANES 1999-2006) were, on average, 29% lower for serum and 45% lower for RBC than were those from the microbiological assay (MA), which was used in NHANES 2007-2010. Roundtable experts agreed that these differences required a data adjustment for time-trend analyses. The roundtable reviewed the possible use of an isotope-dilution liquid chromatography-tandem mass spectrometry (LC-MS/MS) measurement procedure for future NHANES and agreed that the close agreement between the MA and LC-MS/MS results for serum folate supported conversion to the LC-MS/MS procedure. However, for RBC folate, the MA gave 25% higher concentrations than did the LC-MS/MS procedure. The roundtable agreed that the use of the LC-MS/MS procedure to measure RBC folate is premature at this time. The roundtable reviewed the reference materials available or under development at the National Institute of Standards and Technology and recognized the challenges related to, and the scientific need for, these materials. They noted the need for a commutability study for the available reference materials for serum 5MTHF and FA. |
| doi_str_mv | 10.3945/ajcn.111.013011 |
| format | Article |
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NHANES has measured serum folate since 1974 and red blood cell (RBC) folate since 1978 with the use of several different measurement procedures. Data on serum 5-methyltetrahydrofolate (5MTHF) and folic acid (FA) concentrations in persons aged ≥60 y are available in NHANES 1999-2002. The roundtable reviewed data that showed that folate concentrations from the Bio-Rad Quantaphase II procedure (Bio-Rad Laboratories, Hercules, CA; used in NHANES 1991-1994 and NHANES 1999-2006) were, on average, 29% lower for serum and 45% lower for RBC than were those from the microbiological assay (MA), which was used in NHANES 2007-2010. Roundtable experts agreed that these differences required a data adjustment for time-trend analyses. The roundtable reviewed the possible use of an isotope-dilution liquid chromatography-tandem mass spectrometry (LC-MS/MS) measurement procedure for future NHANES and agreed that the close agreement between the MA and LC-MS/MS results for serum folate supported conversion to the LC-MS/MS procedure. However, for RBC folate, the MA gave 25% higher concentrations than did the LC-MS/MS procedure. The roundtable agreed that the use of the LC-MS/MS procedure to measure RBC folate is premature at this time. The roundtable reviewed the reference materials available or under development at the National Institute of Standards and Technology and recognized the challenges related to, and the scientific need for, these materials. They noted the need for a commutability study for the available reference materials for serum 5MTHF and FA.</description><identifier>ISSN: 0002-9165</identifier><identifier>EISSN: 1938-3207</identifier><identifier>DOI: 10.3945/ajcn.111.013011</identifier><identifier>PMID: 21593502</identifier><identifier>CODEN: AJCNAC</identifier><language>eng</language><publisher>Bethesda, MD: American Society for Nutrition</publisher><subject>Biological and medical sciences ; Biomarkers ; Biomarkers - blood ; Chromatography ; Chromatography, Liquid ; Erythrocytes - chemistry ; Feeding. Feeding behavior ; Folic Acid - blood ; Fundamental and applied biological sciences. Psychology ; Humans ; Mass spectrometry ; Microbiological Techniques ; NHANES Monitoring of Biomarkers of Folate and Vitamin B-12 Status: a Roundtable Review ; Nutrition ; Nutrition Surveys ; Radioligand Assay ; Reference Standards ; Tandem Mass Spectrometry ; Vertebrates: anatomy and physiology, studies on body, several organs or systems ; Vitamin B</subject><ispartof>The American journal of clinical nutrition, 2011-07, Vol.94 (1), p.303S-312S</ispartof><rights>2015 INIST-CNRS</rights><rights>Copyright American Society for Clinical Nutrition, Inc. Jul 1, 2011</rights><rights>2011 American Society for Nutrition 2011</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c449t-1e6e1aa29a6f6b7297b24e89455091df5d4eae595d1f075abbb262a996e5b0bc3</citedby><cites>FETCH-LOGICAL-c449t-1e6e1aa29a6f6b7297b24e89455091df5d4eae595d1f075abbb262a996e5b0bc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,309,310,314,776,780,785,786,881,23909,23910,25118,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24302527$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21593502$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>YETLEY, Elizabeth A</creatorcontrib><creatorcontrib>PFEIFFER, Christine M</creatorcontrib><creatorcontrib>RANDY CURTIN, L</creatorcontrib><creatorcontrib>DURAZO-ARVIZU, Ramón A</creatorcontrib><creatorcontrib>ECKFELDT, John H</creatorcontrib><creatorcontrib>GREEN, Ralph</creatorcontrib><creatorcontrib>GREGORY, Jesse F</creatorcontrib><creatorcontrib>HOOFNAGLE, Andrew N</creatorcontrib><creatorcontrib>JACOBSEN, Donald W</creatorcontrib><creatorcontrib>JACQUES, Paul F</creatorcontrib><creatorcontrib>MOLLOY, Anne M</creatorcontrib><creatorcontrib>MASSARO, Joseph</creatorcontrib><creatorcontrib>PHINNEY, Karen W</creatorcontrib><creatorcontrib>MILLS, James L</creatorcontrib><creatorcontrib>NEXO, Ebba</creatorcontrib><creatorcontrib>RADER, Jeanne I</creatorcontrib><creatorcontrib>SELHUB, Jacob</creatorcontrib><creatorcontrib>SEMPOS, Christopher</creatorcontrib><creatorcontrib>SHANE, Barry</creatorcontrib><creatorcontrib>PATRICK STOVER, Sally Stabler</creatorcontrib><creatorcontrib>TAMURA, Tsunenobu</creatorcontrib><creatorcontrib>TEDSTONE, Alison</creatorcontrib><creatorcontrib>THORPE, Susan J</creatorcontrib><creatorcontrib>FAZILI, Zia</creatorcontrib><creatorcontrib>COATES, Paul M</creatorcontrib><creatorcontrib>JOHNSON, Clifford L</creatorcontrib><creatorcontrib>PICCIANO, Mary Frances</creatorcontrib><creatorcontrib>LACHER, David A</creatorcontrib><creatorcontrib>BAILEY, Regan L</creatorcontrib><creatorcontrib>BLACKMORE, Sheena</creatorcontrib><creatorcontrib>BOCK, Jay L</creatorcontrib><creatorcontrib>BRODY, Lawrence C</creatorcontrib><creatorcontrib>CARMEL, Ralph</creatorcontrib><title>Biomarkers of folate status in NHANES: a roundtable summary</title><title>The American journal of clinical nutrition</title><addtitle>Am J Clin Nutr</addtitle><description>A roundtable to discuss the measurement of folate status biomarkers in NHANES took place in July 2010. NHANES has measured serum folate since 1974 and red blood cell (RBC) folate since 1978 with the use of several different measurement procedures. Data on serum 5-methyltetrahydrofolate (5MTHF) and folic acid (FA) concentrations in persons aged ≥60 y are available in NHANES 1999-2002. The roundtable reviewed data that showed that folate concentrations from the Bio-Rad Quantaphase II procedure (Bio-Rad Laboratories, Hercules, CA; used in NHANES 1991-1994 and NHANES 1999-2006) were, on average, 29% lower for serum and 45% lower for RBC than were those from the microbiological assay (MA), which was used in NHANES 2007-2010. Roundtable experts agreed that these differences required a data adjustment for time-trend analyses. The roundtable reviewed the possible use of an isotope-dilution liquid chromatography-tandem mass spectrometry (LC-MS/MS) measurement procedure for future NHANES and agreed that the close agreement between the MA and LC-MS/MS results for serum folate supported conversion to the LC-MS/MS procedure. However, for RBC folate, the MA gave 25% higher concentrations than did the LC-MS/MS procedure. The roundtable agreed that the use of the LC-MS/MS procedure to measure RBC folate is premature at this time. The roundtable reviewed the reference materials available or under development at the National Institute of Standards and Technology and recognized the challenges related to, and the scientific need for, these materials. They noted the need for a commutability study for the available reference materials for serum 5MTHF and FA.</description><subject>Biological and medical sciences</subject><subject>Biomarkers</subject><subject>Biomarkers - blood</subject><subject>Chromatography</subject><subject>Chromatography, Liquid</subject><subject>Erythrocytes - chemistry</subject><subject>Feeding. Feeding behavior</subject><subject>Folic Acid - blood</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>Mass spectrometry</subject><subject>Microbiological Techniques</subject><subject>NHANES Monitoring of Biomarkers of Folate and Vitamin B-12 Status: a Roundtable Review</subject><subject>Nutrition</subject><subject>Nutrition Surveys</subject><subject>Radioligand Assay</subject><subject>Reference Standards</subject><subject>Tandem Mass Spectrometry</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><subject>Vitamin B</subject><issn>0002-9165</issn><issn>1938-3207</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkUtLxDAURoMozvhYu5MiiKvO5CZN2ygIOowPEF2o63DTptqx02jSCv57M8z4XGVxz_34bg4he0BHXCZijLOiHQHAiAKnAGtkCJLnMWc0WydDSimLJaRiQLa8n1EKLMnTTTJgICQXlA3JyXlt5-hejPORraLKNtiZyHfY9T6q2-j26ux2en8cYeRs35Yd6iaM-3nY-dghGxU23uyu3m3yeDF9mFzFN3eX15Ozm7hIEtnFYFIDiExiWqU6YzLTLDF5qC-ohLISZWLQCClKqGgmUGvNUoZSpkZoqgu-TU6Xua-9npuyMG3nsFGvrl60UBZr9XfS1s_qyb4rDiwTkIWAo1WAs2-98Z2a174wTYOtsb1XecY5iPBzgTz4R85s79pwXYDylPNcsgCNl1DhrPfOVN9VgKqFFrXQooIWtdQSNvZ_X_DNf3kIwOEKQF9gUzlsi9r_cAmnTLCMfwIta5VV</recordid><startdate>20110701</startdate><enddate>20110701</enddate><creator>YETLEY, Elizabeth A</creator><creator>PFEIFFER, Christine M</creator><creator>RANDY CURTIN, L</creator><creator>DURAZO-ARVIZU, Ramón A</creator><creator>ECKFELDT, John H</creator><creator>GREEN, Ralph</creator><creator>GREGORY, Jesse F</creator><creator>HOOFNAGLE, Andrew N</creator><creator>JACOBSEN, Donald W</creator><creator>JACQUES, Paul F</creator><creator>MOLLOY, Anne M</creator><creator>MASSARO, Joseph</creator><creator>PHINNEY, Karen W</creator><creator>MILLS, James L</creator><creator>NEXO, Ebba</creator><creator>RADER, Jeanne I</creator><creator>SELHUB, Jacob</creator><creator>SEMPOS, Christopher</creator><creator>SHANE, Barry</creator><creator>PATRICK STOVER, Sally Stabler</creator><creator>TAMURA, Tsunenobu</creator><creator>TEDSTONE, Alison</creator><creator>THORPE, Susan J</creator><creator>FAZILI, Zia</creator><creator>COATES, Paul M</creator><creator>JOHNSON, Clifford L</creator><creator>PICCIANO, Mary Frances</creator><creator>LACHER, David A</creator><creator>BAILEY, Regan L</creator><creator>BLACKMORE, Sheena</creator><creator>BOCK, Jay L</creator><creator>BRODY, Lawrence C</creator><creator>CARMEL, Ralph</creator><general>American Society for Nutrition</general><general>American Society for Clinical Nutrition, Inc</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7T7</scope><scope>7TS</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>P64</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20110701</creationdate><title>Biomarkers of folate status in NHANES: a roundtable summary</title><author>YETLEY, Elizabeth A ; PFEIFFER, Christine M ; RANDY CURTIN, L ; DURAZO-ARVIZU, Ramón A ; ECKFELDT, John H ; GREEN, Ralph ; GREGORY, Jesse F ; HOOFNAGLE, Andrew N ; JACOBSEN, Donald W ; JACQUES, Paul F ; MOLLOY, Anne M ; MASSARO, Joseph ; PHINNEY, Karen W ; MILLS, James L ; NEXO, Ebba ; RADER, Jeanne I ; SELHUB, Jacob ; SEMPOS, Christopher ; SHANE, Barry ; PATRICK STOVER, Sally Stabler ; TAMURA, Tsunenobu ; TEDSTONE, Alison ; THORPE, Susan J ; FAZILI, Zia ; COATES, Paul M ; JOHNSON, Clifford L ; PICCIANO, Mary Frances ; LACHER, David A ; BAILEY, Regan L ; BLACKMORE, Sheena ; BOCK, Jay L ; BRODY, Lawrence C ; CARMEL, Ralph</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c449t-1e6e1aa29a6f6b7297b24e89455091df5d4eae595d1f075abbb262a996e5b0bc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Biological and medical sciences</topic><topic>Biomarkers</topic><topic>Biomarkers - blood</topic><topic>Chromatography</topic><topic>Chromatography, Liquid</topic><topic>Erythrocytes - chemistry</topic><topic>Feeding. 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The roundtable reviewed the possible use of an isotope-dilution liquid chromatography-tandem mass spectrometry (LC-MS/MS) measurement procedure for future NHANES and agreed that the close agreement between the MA and LC-MS/MS results for serum folate supported conversion to the LC-MS/MS procedure. However, for RBC folate, the MA gave 25% higher concentrations than did the LC-MS/MS procedure. The roundtable agreed that the use of the LC-MS/MS procedure to measure RBC folate is premature at this time. The roundtable reviewed the reference materials available or under development at the National Institute of Standards and Technology and recognized the challenges related to, and the scientific need for, these materials. They noted the need for a commutability study for the available reference materials for serum 5MTHF and FA.</abstract><cop>Bethesda, MD</cop><pub>American Society for Nutrition</pub><pmid>21593502</pmid><doi>10.3945/ajcn.111.013011</doi><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0002-9165 |
| ispartof | The American journal of clinical nutrition, 2011-07, Vol.94 (1), p.303S-312S |
| issn | 0002-9165 1938-3207 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3127517 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Biological and medical sciences Biomarkers Biomarkers - blood Chromatography Chromatography, Liquid Erythrocytes - chemistry Feeding. Feeding behavior Folic Acid - blood Fundamental and applied biological sciences. Psychology Humans Mass spectrometry Microbiological Techniques NHANES Monitoring of Biomarkers of Folate and Vitamin B-12 Status: a Roundtable Review Nutrition Nutrition Surveys Radioligand Assay Reference Standards Tandem Mass Spectrometry Vertebrates: anatomy and physiology, studies on body, several organs or systems Vitamin B |
| title | Biomarkers of folate status in NHANES: a roundtable summary |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-09T07%3A32%3A33IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Biomarkers%20of%20folate%20status%20in%20NHANES:%20a%20roundtable%20summary&rft.jtitle=The%20American%20journal%20of%20clinical%20nutrition&rft.au=YETLEY,%20Elizabeth%20A&rft.date=2011-07-01&rft.volume=94&rft.issue=1&rft.spage=303S&rft.epage=312S&rft.pages=303S-312S&rft.issn=0002-9165&rft.eissn=1938-3207&rft.coden=AJCNAC&rft_id=info:doi/10.3945/ajcn.111.013011&rft_dat=%3Cproquest_pubme%3E2404918951%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=878633892&rft_id=info:pmid/21593502&rfr_iscdi=true |