Effects of weight loss on serum vitamin D in postmenopausal women
Low concentrations of circulating vitamin D are common with obesity and may represent a potential mechanism explaining the elevated risk of certain cancers and cardiovascular outcomes observed in individuals who are overweight or obese. The objective of this study was to investigate the effects of 1...
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| Veröffentlicht in: | The American journal of clinical nutrition 2011-07, Vol.94 (1), p.95-103 |
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| creator | MASON, Caitlin LIREN XIAO LI LI JEFFERY, Robert W ROBIEN, Kim ALFANO, Catherine M BLACKBURN, George L MCTIERNAN, Anne IMAYAMA, Ikuyo DUGGAN, Catherine R BAIN, Carolyn FOSTER-SCHUBERT, Karen E KONG, Angela CAMPBELL, Kristin L WANG, Ching-Yun NEUHOUSER, Marian L |
| description | Low concentrations of circulating vitamin D are common with obesity and may represent a potential mechanism explaining the elevated risk of certain cancers and cardiovascular outcomes observed in individuals who are overweight or obese.
The objective of this study was to investigate the effects of 12 mo of weight loss through caloric restriction, exercise intervention, or both on serum 25-hydroxyvitamin D [25(OH)D] concentrations.
Overweight and obese postmenopausal women (n = 439) were randomly assigned to 1 of 4 groups: 1) diet modification (n = 118), 2) exercise (n = 117), 3) diet + exercise (n = 117), or 4) control (n = 87). The diet intervention was a group-based reduced-calorie program with a 10% weight-loss goal. The exercise intervention consisted of 45 min of moderate-to-vigorous intensity aerobic activity daily for 5 d/wk. Serum 25(OH)D concentrations were measured by using a competitive chemiluminescent immunoassay at baseline and 12 mo.
No significant change in serum 25(OH)D was found between the intervention and control groups. Women who lost |
| doi_str_mv | 10.3945/ajcn.111.015552 |
| format | Article |
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The objective of this study was to investigate the effects of 12 mo of weight loss through caloric restriction, exercise intervention, or both on serum 25-hydroxyvitamin D [25(OH)D] concentrations.
Overweight and obese postmenopausal women (n = 439) were randomly assigned to 1 of 4 groups: 1) diet modification (n = 118), 2) exercise (n = 117), 3) diet + exercise (n = 117), or 4) control (n = 87). The diet intervention was a group-based reduced-calorie program with a 10% weight-loss goal. The exercise intervention consisted of 45 min of moderate-to-vigorous intensity aerobic activity daily for 5 d/wk. Serum 25(OH)D concentrations were measured by using a competitive chemiluminescent immunoassay at baseline and 12 mo.
No significant change in serum 25(OH)D was found between the intervention and control groups. Women who lost <5%, 5-9.9%, 10-14.9%, or ≥15% of baseline weight had mean increases in 25(OH)D of 2.1, 2.7, 3.3, and 7.7 ng/mL, respectively (P for trend = 0.002). Baseline vitamin D status did not modify the effect of the interventions on weight loss or body-composition changes at the 12-mo follow-up.
A greater degree of weight loss, achieved through either a reduced-calorie diet or increased exercise, is associated with increased circulating 25(OH)D concentrations. This trial is registered at clinicaltrials.gov as NCT00470119.</description><identifier>ISSN: 0002-9165</identifier><identifier>EISSN: 1938-3207</identifier><identifier>DOI: 10.3945/ajcn.111.015552</identifier><identifier>PMID: 21613554</identifier><identifier>CODEN: AJCNAC</identifier><language>eng</language><publisher>Bethesda, MD: American Society for Nutrition</publisher><subject>Aged ; Biological and medical sciences ; Blood ; Caloric Restriction ; Diet (effects) ; Exercise ; Exercise (intensity) ; Feeding. Feeding behavior ; Female ; Fundamental and applied biological sciences. Psychology ; Humans ; Menopause ; Middle Aged ; Nutrition ; Nutritional Status, Dietary Intake, and Body Composition ; Obesity ; Postmenopause - blood ; Programs ; Sunlight ; Vertebrates: anatomy and physiology, studies on body, several organs or systems ; Vitamin D ; Vitamin D - analogs & derivatives ; Vitamin D - blood ; Vitamins ; Weight control ; Weight Loss ; Women</subject><ispartof>The American journal of clinical nutrition, 2011-07, Vol.94 (1), p.95-103</ispartof><rights>2015 INIST-CNRS</rights><rights>Copyright American Society for Clinical Nutrition, Inc. Jul 1, 2011</rights><rights>2011 American Society for Nutrition 2011</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a571t-6960514d1e90ab89cc90598ae84e6e82f27f9fde6d1c9159da7bb3fab90d35d63</citedby><cites>FETCH-LOGICAL-a571t-6960514d1e90ab89cc90598ae84e6e82f27f9fde6d1c9159da7bb3fab90d35d63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24302502$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21613554$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>MASON, Caitlin</creatorcontrib><creatorcontrib>LIREN XIAO</creatorcontrib><creatorcontrib>LI LI</creatorcontrib><creatorcontrib>JEFFERY, Robert W</creatorcontrib><creatorcontrib>ROBIEN, Kim</creatorcontrib><creatorcontrib>ALFANO, Catherine M</creatorcontrib><creatorcontrib>BLACKBURN, George L</creatorcontrib><creatorcontrib>MCTIERNAN, Anne</creatorcontrib><creatorcontrib>IMAYAMA, Ikuyo</creatorcontrib><creatorcontrib>DUGGAN, Catherine R</creatorcontrib><creatorcontrib>BAIN, Carolyn</creatorcontrib><creatorcontrib>FOSTER-SCHUBERT, Karen E</creatorcontrib><creatorcontrib>KONG, Angela</creatorcontrib><creatorcontrib>CAMPBELL, Kristin L</creatorcontrib><creatorcontrib>WANG, Ching-Yun</creatorcontrib><creatorcontrib>NEUHOUSER, Marian L</creatorcontrib><title>Effects of weight loss on serum vitamin D in postmenopausal women</title><title>The American journal of clinical nutrition</title><addtitle>Am J Clin Nutr</addtitle><description>Low concentrations of circulating vitamin D are common with obesity and may represent a potential mechanism explaining the elevated risk of certain cancers and cardiovascular outcomes observed in individuals who are overweight or obese.
The objective of this study was to investigate the effects of 12 mo of weight loss through caloric restriction, exercise intervention, or both on serum 25-hydroxyvitamin D [25(OH)D] concentrations.
Overweight and obese postmenopausal women (n = 439) were randomly assigned to 1 of 4 groups: 1) diet modification (n = 118), 2) exercise (n = 117), 3) diet + exercise (n = 117), or 4) control (n = 87). The diet intervention was a group-based reduced-calorie program with a 10% weight-loss goal. The exercise intervention consisted of 45 min of moderate-to-vigorous intensity aerobic activity daily for 5 d/wk. Serum 25(OH)D concentrations were measured by using a competitive chemiluminescent immunoassay at baseline and 12 mo.
No significant change in serum 25(OH)D was found between the intervention and control groups. Women who lost <5%, 5-9.9%, 10-14.9%, or ≥15% of baseline weight had mean increases in 25(OH)D of 2.1, 2.7, 3.3, and 7.7 ng/mL, respectively (P for trend = 0.002). Baseline vitamin D status did not modify the effect of the interventions on weight loss or body-composition changes at the 12-mo follow-up.
A greater degree of weight loss, achieved through either a reduced-calorie diet or increased exercise, is associated with increased circulating 25(OH)D concentrations. This trial is registered at clinicaltrials.gov as NCT00470119.</description><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Blood</subject><subject>Caloric Restriction</subject><subject>Diet (effects)</subject><subject>Exercise</subject><subject>Exercise (intensity)</subject><subject>Feeding. Feeding behavior</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>Menopause</subject><subject>Middle Aged</subject><subject>Nutrition</subject><subject>Nutritional Status, Dietary Intake, and Body Composition</subject><subject>Obesity</subject><subject>Postmenopause - blood</subject><subject>Programs</subject><subject>Sunlight</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><subject>Vitamin D</subject><subject>Vitamin D - analogs & derivatives</subject><subject>Vitamin D - blood</subject><subject>Vitamins</subject><subject>Weight control</subject><subject>Weight Loss</subject><subject>Women</subject><issn>0002-9165</issn><issn>1938-3207</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kUFP3DAQRi1EVRbaMzcUIVX0kmXGjp34goSAlkpIvdCz5Tg2ZJXYi52A-u8x2oW2HHrxaDTPn-x5hBwiLJms-KleGb9ExCUg55zukAVK1pSMQr1LFgBAS4mC75H9lFYASKtGfCR7FAUyzqsFOb9yzpopFcEVT7a_u5-KIaTc-iLZOI_FYz_psffFZZGPdUjTaH1Y6znpoXgKuflEPjg9JPt5Ww_Ir29XtxfX5c3P7z8uzm9KzWucSiEFcKw6tBJ020hjJHDZaNtUVtiGOlo76TorOjQSuex03bbM6VZCx3gn2AE52-Su53a0nbF-inpQ69iPOv5WQffq34nv79VdeFQMac0Rc8DJNiCGh9mmSY19MnYYtLdhTqqpGcNKYJ3Jr_8lERApUqBVRo_foaswR58XkfMawWomIEOnG8jEvNto3durEdSLR_XiUWWPauMx3zj6-7Nv_Ku4DHzZAjoZPbiovenTH65iQDlQ9gyCa6YA</recordid><startdate>20110701</startdate><enddate>20110701</enddate><creator>MASON, Caitlin</creator><creator>LIREN XIAO</creator><creator>LI LI</creator><creator>JEFFERY, Robert W</creator><creator>ROBIEN, Kim</creator><creator>ALFANO, Catherine M</creator><creator>BLACKBURN, George L</creator><creator>MCTIERNAN, Anne</creator><creator>IMAYAMA, Ikuyo</creator><creator>DUGGAN, Catherine R</creator><creator>BAIN, Carolyn</creator><creator>FOSTER-SCHUBERT, Karen E</creator><creator>KONG, Angela</creator><creator>CAMPBELL, Kristin L</creator><creator>WANG, Ching-Yun</creator><creator>NEUHOUSER, Marian L</creator><general>American Society for Nutrition</general><general>American Society for Clinical Nutrition, Inc</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7T7</scope><scope>7TS</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>P64</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20110701</creationdate><title>Effects of weight loss on serum vitamin D in postmenopausal women</title><author>MASON, Caitlin ; LIREN XIAO ; LI LI ; JEFFERY, Robert W ; ROBIEN, Kim ; ALFANO, Catherine M ; BLACKBURN, George L ; MCTIERNAN, Anne ; IMAYAMA, Ikuyo ; DUGGAN, Catherine R ; BAIN, Carolyn ; FOSTER-SCHUBERT, Karen E ; KONG, Angela ; CAMPBELL, Kristin L ; WANG, Ching-Yun ; NEUHOUSER, Marian L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a571t-6960514d1e90ab89cc90598ae84e6e82f27f9fde6d1c9159da7bb3fab90d35d63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Blood</topic><topic>Caloric Restriction</topic><topic>Diet (effects)</topic><topic>Exercise</topic><topic>Exercise (intensity)</topic><topic>Feeding. Feeding behavior</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Humans</topic><topic>Menopause</topic><topic>Middle Aged</topic><topic>Nutrition</topic><topic>Nutritional Status, Dietary Intake, and Body Composition</topic><topic>Obesity</topic><topic>Postmenopause - blood</topic><topic>Programs</topic><topic>Sunlight</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><topic>Vitamin D</topic><topic>Vitamin D - analogs & derivatives</topic><topic>Vitamin D - blood</topic><topic>Vitamins</topic><topic>Weight control</topic><topic>Weight Loss</topic><topic>Women</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>MASON, Caitlin</creatorcontrib><creatorcontrib>LIREN XIAO</creatorcontrib><creatorcontrib>LI LI</creatorcontrib><creatorcontrib>JEFFERY, Robert W</creatorcontrib><creatorcontrib>ROBIEN, Kim</creatorcontrib><creatorcontrib>ALFANO, Catherine M</creatorcontrib><creatorcontrib>BLACKBURN, George L</creatorcontrib><creatorcontrib>MCTIERNAN, Anne</creatorcontrib><creatorcontrib>IMAYAMA, Ikuyo</creatorcontrib><creatorcontrib>DUGGAN, Catherine R</creatorcontrib><creatorcontrib>BAIN, Carolyn</creatorcontrib><creatorcontrib>FOSTER-SCHUBERT, Karen E</creatorcontrib><creatorcontrib>KONG, Angela</creatorcontrib><creatorcontrib>CAMPBELL, Kristin L</creatorcontrib><creatorcontrib>WANG, Ching-Yun</creatorcontrib><creatorcontrib>NEUHOUSER, Marian L</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Physical Education Index</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The American journal of clinical nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>MASON, Caitlin</au><au>LIREN XIAO</au><au>LI LI</au><au>JEFFERY, Robert W</au><au>ROBIEN, Kim</au><au>ALFANO, Catherine M</au><au>BLACKBURN, George L</au><au>MCTIERNAN, Anne</au><au>IMAYAMA, Ikuyo</au><au>DUGGAN, Catherine R</au><au>BAIN, Carolyn</au><au>FOSTER-SCHUBERT, Karen E</au><au>KONG, Angela</au><au>CAMPBELL, Kristin L</au><au>WANG, Ching-Yun</au><au>NEUHOUSER, Marian L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of weight loss on serum vitamin D in postmenopausal women</atitle><jtitle>The American journal of clinical nutrition</jtitle><addtitle>Am J Clin Nutr</addtitle><date>2011-07-01</date><risdate>2011</risdate><volume>94</volume><issue>1</issue><spage>95</spage><epage>103</epage><pages>95-103</pages><issn>0002-9165</issn><eissn>1938-3207</eissn><coden>AJCNAC</coden><abstract>Low concentrations of circulating vitamin D are common with obesity and may represent a potential mechanism explaining the elevated risk of certain cancers and cardiovascular outcomes observed in individuals who are overweight or obese.
The objective of this study was to investigate the effects of 12 mo of weight loss through caloric restriction, exercise intervention, or both on serum 25-hydroxyvitamin D [25(OH)D] concentrations.
Overweight and obese postmenopausal women (n = 439) were randomly assigned to 1 of 4 groups: 1) diet modification (n = 118), 2) exercise (n = 117), 3) diet + exercise (n = 117), or 4) control (n = 87). The diet intervention was a group-based reduced-calorie program with a 10% weight-loss goal. The exercise intervention consisted of 45 min of moderate-to-vigorous intensity aerobic activity daily for 5 d/wk. Serum 25(OH)D concentrations were measured by using a competitive chemiluminescent immunoassay at baseline and 12 mo.
No significant change in serum 25(OH)D was found between the intervention and control groups. Women who lost <5%, 5-9.9%, 10-14.9%, or ≥15% of baseline weight had mean increases in 25(OH)D of 2.1, 2.7, 3.3, and 7.7 ng/mL, respectively (P for trend = 0.002). Baseline vitamin D status did not modify the effect of the interventions on weight loss or body-composition changes at the 12-mo follow-up.
A greater degree of weight loss, achieved through either a reduced-calorie diet or increased exercise, is associated with increased circulating 25(OH)D concentrations. This trial is registered at clinicaltrials.gov as NCT00470119.</abstract><cop>Bethesda, MD</cop><pub>American Society for Nutrition</pub><pmid>21613554</pmid><doi>10.3945/ajcn.111.015552</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Aged Biological and medical sciences Blood Caloric Restriction Diet (effects) Exercise Exercise (intensity) Feeding. Feeding behavior Female Fundamental and applied biological sciences. Psychology Humans Menopause Middle Aged Nutrition Nutritional Status, Dietary Intake, and Body Composition Obesity Postmenopause - blood Programs Sunlight Vertebrates: anatomy and physiology, studies on body, several organs or systems Vitamin D Vitamin D - analogs & derivatives Vitamin D - blood Vitamins Weight control Weight Loss Women |
| title | Effects of weight loss on serum vitamin D in postmenopausal women |
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