Toxicological screening
Toxicity testing of new compounds is essential for drug development process. The preclinical toxicity testing on various biological systems reveals the species-, organ- and dose- specific toxic effects of an investigational product. The toxicity of substances can be observed by (a) studying the acci...
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| Veröffentlicht in: | Journal of pharmacology & pharmacotherapeutics 2011-04, Vol.2 (2), p.74-79 |
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| container_title | Journal of pharmacology & pharmacotherapeutics |
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| creator | Parasuraman, S |
| description | Toxicity testing of new compounds is essential for drug development process. The preclinical toxicity testing on various biological systems reveals the species-, organ- and dose- specific toxic effects of an investigational product. The toxicity of substances can be observed by (a) studying the accidental exposures to a substance (b) in vitro studies using cells/ cell lines (c) in vivo exposure on experimental animals. This review mainly focuses on the various experimental animal models and methods used for toxicity testing of substances. The pre-clinical toxicity testing helps to calculate "No Observed Adverse Effect Level" which is needed to initiate the clinical evaluation of investigational products. |
| doi_str_mv | 10.4103/0976-500X.81895 |
| format | Article |
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| ispartof | Journal of pharmacology & pharmacotherapeutics, 2011-04, Vol.2 (2), p.74-79 |
| issn | 0976-500X 0976-5018 |
| language | eng |
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| source | Sage Journals GOLD Open Access 2024; PubMed Central Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Drugs Educational Forum Health aspects Toxicity testing |
| title | Toxicological screening |
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