Autophagy in mammalian development and differentiation

It has been known for many decades that autophagy, a conserved lysosomal degradation pathway, is highly active during differentiation and development. However, until the discovery of the autophagy-related ( ATG ) genes in the 1990s, the functional significance of this activity was unknown. Initially...

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Veröffentlicht in:	Nature cell biology 2010-09, Vol.12 (9), p.823-830
Hauptverfasser:	Mizushima, Noboru, Levine, Beth
Format:	Artikel
Sprache:	eng
Schlagworte:	631/136/142 631/136/2086 631/80/82/39 Animals Autophagy Autophagy (Cytology) Autophagy - physiology Biomedical and Life Sciences Cancer Research Cell Biology Cell Differentiation - physiology Cell division Developmental Biology Embryonic development Embryos Endoplasmic reticulum Genes Genetic aspects Growth and Development - physiology Homeostasis - physiology Humans Life Sciences Lysosomes Mammals Mitochondria Physiological aspects Physiology Proteins review-article Stem Cells
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