Individual variations in inorganic arsenic metabolism associated with AS3MT genetic polymorphisms
Individual variations in inorganic arsenic metabolism may influence the toxic effects. Arsenic (+3 oxidation state) methyltransferase (AS3MT) that can catalyze the transfer of a methyl group from S-adenosyl-l-methionine (AdoMet) to trivalent arsenical, may play a role in arsenic metabolism in humans...
Gespeichert in:
| Veröffentlicht in: | International journal of molecular sciences 2011-04, Vol.12 (4), p.2351-2382 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 2382 |
|---|---|
| container_issue | 4 |
| container_start_page | 2351 |
| container_title | International journal of molecular sciences |
| container_volume | 12 |
| creator | Agusa, Tetsuro Fujihara, Junko Takeshita, Haruo Iwata, Hisato |
| description | Individual variations in inorganic arsenic metabolism may influence the toxic effects. Arsenic (+3 oxidation state) methyltransferase (AS3MT) that can catalyze the transfer of a methyl group from S-adenosyl-l-methionine (AdoMet) to trivalent arsenical, may play a role in arsenic metabolism in humans. Since the genetic polymorphisms of AS3MT gene may be associated with the susceptibility to inorganic arsenic toxicity, relationships of several single nucleotide polymorphisms (SNPs) in AS3MT with inorganic arsenic metabolism have been investigated. Here, we summarize our recent findings and other previous studies on the inorganic arsenic metabolism and AS3MT genetic polymorphisms in humans. Results of genotype dependent differences in arsenic metabolism for most of SNPs in AS3MT were Inconsistent throughout the studies. Nevertheless, two SNPs, AS3MT 12390 (rs3740393) and 14458 (rs11191439) were consistently related to arsenic methylation regardless of the populations examined for the analysis. Thus, these SNPs may be useful indicators to predict the arsenic metabolism via methylation pathways. |
| doi_str_mv | 10.3390/ijms12042351 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3127122</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>923202712</sourcerecordid><originalsourceid>FETCH-LOGICAL-c487t-877a420eb3b6e7bc57b3f99b9d532fcbefc8c9dc24c1c82200d5133b2fc0c7ac3</originalsourceid><addsrcrecordid>eNpd0c9LwzAUB_AgipvTm2cpePBiNT_apr0IY_hjoHhwnkOSpltGm8ykney_N2VzTCHwAu_D4yVfAC4RvCOkgPd62XiEYYJJio7AECUYxxBm9PjgPgBn3i8hxASnxSkYYEQJSpJsCPjUlHqty47X0Zo7zVttjY-0Cce6OTdaRtx51ddGtVzYWvsm4t5bGbAqo2_dLqLxB3mbRXNlVBvgytabxrrVIlB_Dk4qXnt1sasj8Pn0OJu8xK_vz9PJ-DWWSU7bOKeUJxgqQUSmqJApFaQqClGUKcGVFKqSuSxKiROJZI4xhGWKCBGhByXlkozAw3buqhONKqUyreM1WzndcLdhlmv2t2P0gs3tmhGEKcI4DLjZDXD2q1O-ZY32UtU1N8p2nhXh92BPg7z-J5e2cya8jqEUZzCEAXt1u1XSWe-dqva7IMj66NhhdIFfHe6_x79ZkR_6sJd6</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1526004202</pqid></control><display><type>article</type><title>Individual variations in inorganic arsenic metabolism associated with AS3MT genetic polymorphisms</title><source>MDPI - Multidisciplinary Digital Publishing Institute</source><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><creator>Agusa, Tetsuro ; Fujihara, Junko ; Takeshita, Haruo ; Iwata, Hisato</creator><creatorcontrib>Agusa, Tetsuro ; Fujihara, Junko ; Takeshita, Haruo ; Iwata, Hisato</creatorcontrib><description>Individual variations in inorganic arsenic metabolism may influence the toxic effects. Arsenic (+3 oxidation state) methyltransferase (AS3MT) that can catalyze the transfer of a methyl group from S-adenosyl-l-methionine (AdoMet) to trivalent arsenical, may play a role in arsenic metabolism in humans. Since the genetic polymorphisms of AS3MT gene may be associated with the susceptibility to inorganic arsenic toxicity, relationships of several single nucleotide polymorphisms (SNPs) in AS3MT with inorganic arsenic metabolism have been investigated. Here, we summarize our recent findings and other previous studies on the inorganic arsenic metabolism and AS3MT genetic polymorphisms in humans. Results of genotype dependent differences in arsenic metabolism for most of SNPs in AS3MT were Inconsistent throughout the studies. Nevertheless, two SNPs, AS3MT 12390 (rs3740393) and 14458 (rs11191439) were consistently related to arsenic methylation regardless of the populations examined for the analysis. Thus, these SNPs may be useful indicators to predict the arsenic metabolism via methylation pathways.</description><identifier>ISSN: 1422-0067</identifier><identifier>ISSN: 1661-6596</identifier><identifier>EISSN: 1422-0067</identifier><identifier>DOI: 10.3390/ijms12042351</identifier><identifier>PMID: 21731446</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Arsenic - metabolism ; Gene Frequency ; Humans ; Methylation ; Methyltransferases - genetics ; Polymorphism, Single Nucleotide ; Racial Groups - genetics ; Review ; S-Adenosylmethionine - chemistry ; S-Adenosylmethionine - metabolism</subject><ispartof>International journal of molecular sciences, 2011-04, Vol.12 (4), p.2351-2382</ispartof><rights>Copyright MDPI AG 2011</rights><rights>2011 by the authors; licensee MDPI, Basel, Switzerland. 2011</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c487t-877a420eb3b6e7bc57b3f99b9d532fcbefc8c9dc24c1c82200d5133b2fc0c7ac3</citedby><cites>FETCH-LOGICAL-c487t-877a420eb3b6e7bc57b3f99b9d532fcbefc8c9dc24c1c82200d5133b2fc0c7ac3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3127122/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3127122/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,313,314,723,776,780,788,881,27899,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21731446$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Agusa, Tetsuro</creatorcontrib><creatorcontrib>Fujihara, Junko</creatorcontrib><creatorcontrib>Takeshita, Haruo</creatorcontrib><creatorcontrib>Iwata, Hisato</creatorcontrib><title>Individual variations in inorganic arsenic metabolism associated with AS3MT genetic polymorphisms</title><title>International journal of molecular sciences</title><addtitle>Int J Mol Sci</addtitle><description>Individual variations in inorganic arsenic metabolism may influence the toxic effects. Arsenic (+3 oxidation state) methyltransferase (AS3MT) that can catalyze the transfer of a methyl group from S-adenosyl-l-methionine (AdoMet) to trivalent arsenical, may play a role in arsenic metabolism in humans. Since the genetic polymorphisms of AS3MT gene may be associated with the susceptibility to inorganic arsenic toxicity, relationships of several single nucleotide polymorphisms (SNPs) in AS3MT with inorganic arsenic metabolism have been investigated. Here, we summarize our recent findings and other previous studies on the inorganic arsenic metabolism and AS3MT genetic polymorphisms in humans. Results of genotype dependent differences in arsenic metabolism for most of SNPs in AS3MT were Inconsistent throughout the studies. Nevertheless, two SNPs, AS3MT 12390 (rs3740393) and 14458 (rs11191439) were consistently related to arsenic methylation regardless of the populations examined for the analysis. Thus, these SNPs may be useful indicators to predict the arsenic metabolism via methylation pathways.</description><subject>Arsenic - metabolism</subject><subject>Gene Frequency</subject><subject>Humans</subject><subject>Methylation</subject><subject>Methyltransferases - genetics</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Racial Groups - genetics</subject><subject>Review</subject><subject>S-Adenosylmethionine - chemistry</subject><subject>S-Adenosylmethionine - metabolism</subject><issn>1422-0067</issn><issn>1661-6596</issn><issn>1422-0067</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNpd0c9LwzAUB_AgipvTm2cpePBiNT_apr0IY_hjoHhwnkOSpltGm8ykney_N2VzTCHwAu_D4yVfAC4RvCOkgPd62XiEYYJJio7AECUYxxBm9PjgPgBn3i8hxASnxSkYYEQJSpJsCPjUlHqty47X0Zo7zVttjY-0Cce6OTdaRtx51ddGtVzYWvsm4t5bGbAqo2_dLqLxB3mbRXNlVBvgytabxrrVIlB_Dk4qXnt1sasj8Pn0OJu8xK_vz9PJ-DWWSU7bOKeUJxgqQUSmqJApFaQqClGUKcGVFKqSuSxKiROJZI4xhGWKCBGhByXlkozAw3buqhONKqUyreM1WzndcLdhlmv2t2P0gs3tmhGEKcI4DLjZDXD2q1O-ZY32UtU1N8p2nhXh92BPg7z-J5e2cya8jqEUZzCEAXt1u1XSWe-dqva7IMj66NhhdIFfHe6_x79ZkR_6sJd6</recordid><startdate>20110401</startdate><enddate>20110401</enddate><creator>Agusa, Tetsuro</creator><creator>Fujihara, Junko</creator><creator>Takeshita, Haruo</creator><creator>Iwata, Hisato</creator><general>MDPI AG</general><general>Molecular Diversity Preservation International (MDPI)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>5PM</scope></search><sort><creationdate>20110401</creationdate><title>Individual variations in inorganic arsenic metabolism associated with AS3MT genetic polymorphisms</title><author>Agusa, Tetsuro ; Fujihara, Junko ; Takeshita, Haruo ; Iwata, Hisato</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c487t-877a420eb3b6e7bc57b3f99b9d532fcbefc8c9dc24c1c82200d5133b2fc0c7ac3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Arsenic - metabolism</topic><topic>Gene Frequency</topic><topic>Humans</topic><topic>Methylation</topic><topic>Methyltransferases - genetics</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Racial Groups - genetics</topic><topic>Review</topic><topic>S-Adenosylmethionine - chemistry</topic><topic>S-Adenosylmethionine - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Agusa, Tetsuro</creatorcontrib><creatorcontrib>Fujihara, Junko</creatorcontrib><creatorcontrib>Takeshita, Haruo</creatorcontrib><creatorcontrib>Iwata, Hisato</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>International journal of molecular sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Agusa, Tetsuro</au><au>Fujihara, Junko</au><au>Takeshita, Haruo</au><au>Iwata, Hisato</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Individual variations in inorganic arsenic metabolism associated with AS3MT genetic polymorphisms</atitle><jtitle>International journal of molecular sciences</jtitle><addtitle>Int J Mol Sci</addtitle><date>2011-04-01</date><risdate>2011</risdate><volume>12</volume><issue>4</issue><spage>2351</spage><epage>2382</epage><pages>2351-2382</pages><issn>1422-0067</issn><issn>1661-6596</issn><eissn>1422-0067</eissn><abstract>Individual variations in inorganic arsenic metabolism may influence the toxic effects. Arsenic (+3 oxidation state) methyltransferase (AS3MT) that can catalyze the transfer of a methyl group from S-adenosyl-l-methionine (AdoMet) to trivalent arsenical, may play a role in arsenic metabolism in humans. Since the genetic polymorphisms of AS3MT gene may be associated with the susceptibility to inorganic arsenic toxicity, relationships of several single nucleotide polymorphisms (SNPs) in AS3MT with inorganic arsenic metabolism have been investigated. Here, we summarize our recent findings and other previous studies on the inorganic arsenic metabolism and AS3MT genetic polymorphisms in humans. Results of genotype dependent differences in arsenic metabolism for most of SNPs in AS3MT were Inconsistent throughout the studies. Nevertheless, two SNPs, AS3MT 12390 (rs3740393) and 14458 (rs11191439) were consistently related to arsenic methylation regardless of the populations examined for the analysis. Thus, these SNPs may be useful indicators to predict the arsenic metabolism via methylation pathways.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>21731446</pmid><doi>10.3390/ijms12042351</doi><tpages>32</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1422-0067 |
| ispartof | International journal of molecular sciences, 2011-04, Vol.12 (4), p.2351-2382 |
| issn | 1422-0067 1661-6596 1422-0067 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3127122 |
| source | MDPI - Multidisciplinary Digital Publishing Institute; MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Arsenic - metabolism Gene Frequency Humans Methylation Methyltransferases - genetics Polymorphism, Single Nucleotide Racial Groups - genetics Review S-Adenosylmethionine - chemistry S-Adenosylmethionine - metabolism |
| title | Individual variations in inorganic arsenic metabolism associated with AS3MT genetic polymorphisms |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-02T14%3A26%3A23IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Individual%20variations%20in%20inorganic%20arsenic%20metabolism%20associated%20with%20AS3MT%20genetic%20polymorphisms&rft.jtitle=International%20journal%20of%20molecular%20sciences&rft.au=Agusa,%20Tetsuro&rft.date=2011-04-01&rft.volume=12&rft.issue=4&rft.spage=2351&rft.epage=2382&rft.pages=2351-2382&rft.issn=1422-0067&rft.eissn=1422-0067&rft_id=info:doi/10.3390/ijms12042351&rft_dat=%3Cproquest_pubme%3E923202712%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1526004202&rft_id=info:pmid/21731446&rfr_iscdi=true |