Myricetin induces pancreatic cancer cell death via the induction of apoptosis and inhibition of the phosphatidylinositol 3-kinase (PI3K) signaling pathway

Abstract Pancreatic cancer is the fourth leading cause of cancer related deaths and is a disease with poor prognosis. It is refractory to standard chemotherapeutic drugs or to novel treatment modalities, making it imperative to find new treatments. In this study, using both primary and metastatic pa...

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Veröffentlicht in:	Cancer letters 2011-09, Vol.308 (2), p.181-188
Hauptverfasser:	Phillips, P.A, Sangwan, V, Borja-Cacho, D, Dudeja, V, Vickers, S.M, Saluja, A.K
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - pharmacology Apoptosis Apoptosis - drug effects Cell Line, Tumor Cell Survival Disease Models, Animal Flavonoids - pharmacology Hematology, Oncology and Palliative Medicine Humans Immunohistochemistry Infrared imaging systems Kinases Medical prognosis Metastasis Mice Mice, Nude Myricetin Orthotopic model Pancreas Pancreatic cancer Pancreatic Neoplasms - pathology Phosphatidylinositol 3-Kinase - antagonists & inhibitors Signal Transduction - drug effects Tumor Cells, Cultured Tumors
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