Mechanistic and Pharmacological Characterization of PF-04457845: A Highly Potent and Selective Fatty Acid Amide Hydrolase Inhibitor That Reduces Inflammatory and Noninflammatory Pain

The endogenous cannabinoid (endocannabinoid) anandamide is principally degraded by the integral membrane enzyme fatty acid amide hydrolase (FAAH). Pharmacological blockade of FAAH has emerged as a potentially attractive strategy for augmenting endocannabinoid signaling and retaining the beneficial e...

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Veröffentlicht in:	The Journal of pharmacology and experimental therapeutics 2011-07, Vol.338 (1), p.114-124
Hauptverfasser:	Ahn, Kay, Smith, Sarah E., Liimatta, Marya B., Beidler, David, Sadagopan, Nalini, Dudley, David T., Young, Tim, Wren, Paul, Zhang, Yanhua, Swaney, Steven, Van Becelaere, Keri, Blankman, Jacqueline L., Nomura, Daniel K., Bhattachar, Shobha N., Stiff, Cory, Nomanbhoy, Tyzoon K., Weerapana, Eranthie, Johnson, Douglas S., Cravatt, Benjamin F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amidohydrolases - antagonists & inhibitors Amidohydrolases - metabolism Animals Drug Discovery and Translational Medicine Enzyme Inhibitors - chemistry Enzyme Inhibitors - pharmacology Enzyme Inhibitors - therapeutic use Humans Inflammation - drug therapy Inflammation - enzymology Inflammation - pathology Male Mice Mice, Inbred C57BL Pain - drug therapy Pain - enzymology Piperidines - chemistry Piperidines - pharmacology Piperidines - therapeutic use Pyridazines - chemistry Pyridazines - pharmacology Pyridazines - therapeutic use Rats Rats, Sprague-Dawley Urea - analogs & derivatives Urea - chemistry Urea - pharmacology Urea - therapeutic use
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