Mzb1 Protein Regulates Calcium Homeostasis, Antibody Secretion, and Integrin Activation in Innate-like B Cells

Marginal zone (MZ) B cells of the spleen and B1 cells, termed innate-like B cells, differ from follicular B cells by their attenuated Ca 2+ mobilization, fast antibody secretion, and increased cell adhesion. We identified and characterized Mzb1 as an endoplasmic reticulum-localized and B cell-specif...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Immunity (Cambridge, Mass.) Mass.), 2010-11, Vol.33 (5), p.723-735
Hauptverfasser:	Flach, Henrik, Rosenbaum, Marc, Duchniewicz, Marlena, Kim, Sola, Zhang, Shenyuan L., Cahalan, Michael D., Mittler, Gerhard, Grosschedl, Rudolf
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acids Animals Antibodies Antibodies - metabolism B-Lymphocytes - metabolism Calcium - metabolism Cell Adhesion Cell culture Cell growth Chemical bonds Homeostasis Immune system Integrins - metabolism Ligands Lipopolysaccharides - immunology Lymphocytes Membrane Glycoproteins - metabolism Mice Mice, Transgenic NFATC Transcription Factors - metabolism Protein Disulfide-Isomerases - metabolism Protein Folding Proteins - chemistry Proteins - genetics Proteins - metabolism Spleen - metabolism T-Lymphocytes - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!