Effects of KATP channel openers diazoxide and pinacidil in coronary-perfused atria and ventricles from failing and non-failing human hearts

Abstract This study compared the effects of ATP-regulated potassium channel (KATP ) openers, diazoxide and pinacidil, on diseased and normal human atria and ventricles. We optically mapped the endocardium of coronary-perfused right ( n = 11) or left ( n = 2) posterior atrial–ventricular free wall pr...

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Veröffentlicht in:	Journal of molecular and cellular cardiology 2011-08, Vol.51 (2), p.215-225
Hauptverfasser:	Fedorov, Vadim V, Glukhov, Alexey V, Ambrosi, Christina M, Kostecki, Geran, Chang, Roger, Janks, Deborah, Schuessler, Richard B, Moazami, Nader, Nichols, Colin G, Efimov, Igor R
Format:	Artikel
Sprache:	eng
Schlagworte:	Action Potentials - drug effects Adolescent Adult Arrhythmias Arrhythmias, Cardiac - physiopathology Cardiovascular Coronary Vessels - drug effects Coronary Vessels - metabolism Diazoxide - pharmacology Female Gene Expression Regulation - drug effects Heart Atria - drug effects Heart Atria - metabolism Heart Atria - physiopathology Heart failure Heart Failure - physiopathology Heart Ventricles - drug effects Heart Ventricles - metabolism Heart Ventricles - physiopathology Human heart IKATP Humans Ischemic heart disease KATP Channels - genetics KATP Channels - metabolism Male Middle Aged Myocardial Ischemia - physiopathology Optical mapping Pinacidil - pharmacology RNA, Messenger - genetics Vasodilator Agents - pharmacology Young Adult
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