Extracellular Superoxide Dismutase in Macrophages Augments Bacterial Killing by Promoting Phagocytosis

Extracellular superoxide dismutase (EC-SOD) is abundant in the lung and limits inflammation and injury in response to many pulmonary insults. To test the hypothesis that EC-SOD has an important role in bacterial infections, wild-type and EC-SOD knockout (KO) mice were infected with Escherichia coli...

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Veröffentlicht in:	The American journal of pathology 2011-06, Vol.178 (6), p.2752-2759
Hauptverfasser:	Manni, Michelle L, Tomai, Lauren P, Norris, Callie A, Thomas, L. Michael, Kelley, Eric E, Salter, Russell D, Crapo, James D, Chang, Ling-Yi L, Watkins, Simon C, Piganelli, Jon D, Oury, Tim D
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Escherichia coli - cytology Extracellular Space - enzymology Humans Inflammation - microbiology Inflammation - pathology Intracellular Space - metabolism Investigative techniques, diagnostic techniques (general aspects) Lung - microbiology Lung - pathology Macrophages - cytology Macrophages - enzymology Macrophages - ultrastructure Medical sciences Mice Mice, Inbred C57BL Mice, Knockout Microbial Viability Oxidants - metabolism Pathology Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Phagocytosis Pneumonia - microbiology Pneumonia - pathology Regular Superoxide Dismutase - metabolism Superoxide Dismutase - ultrastructure
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