Effects of exogenous antioxidants on oxidative stress in pregnancy
The present study evaluated the effects on gestation, in terms of oxidative stress, of two antioxidant factors-vitamin E and coenzyme Q10-during pregnancy, with the purpose of applying the results in further human clinical practice. For each aspect we have studied, we used three types of female rats...
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| Veröffentlicht in: | Journal of medicine and life 2011-05, Vol.4 (2), p.163-167 |
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| creator | Staicu, M L Mureşan, A Tache, S Moldovan, R |
| description | The present study evaluated the effects on gestation, in terms of oxidative stress, of two antioxidant factors-vitamin E and coenzyme Q10-during pregnancy, with the purpose of applying the results in further human clinical practice.
For each aspect we have studied, we used three types of female rats of Wistar race (un-pregnant, primiparous, multiparous), divided in 10 rats/group. From the blood we have sampled, we have determined the oxidative stress (OS) markers: malondialdehyde (MDA) and carbonylated proteins (CP), but also the markers of the antioxidant defense: the hydrogen donor capacity of the plasma (HD) and the sulfhydryl groups (SH).
Vitamin E administration determines significant decreases of MDA and significant increases of CP and HD at primiparous, and also significant increases of SH groups at multiparous. In the case of pregnant animals that received CoQ10 in antioxidant complexes, we have observed an increase of oxidative stress (OS)-MDA in primiparous and CP in multiparous.
In the case of Vitamin E, taking into account the benefits on redox homeostasis, the decrease of OS, the authors recommend vitamin E administration during pregnancy. However, because of the increase of the OS in the case of pregnant animals, the authors do not recommend the administration of CoQ(10) in antioxidant complexes during pregnancy. |
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For each aspect we have studied, we used three types of female rats of Wistar race (un-pregnant, primiparous, multiparous), divided in 10 rats/group. From the blood we have sampled, we have determined the oxidative stress (OS) markers: malondialdehyde (MDA) and carbonylated proteins (CP), but also the markers of the antioxidant defense: the hydrogen donor capacity of the plasma (HD) and the sulfhydryl groups (SH).
Vitamin E administration determines significant decreases of MDA and significant increases of CP and HD at primiparous, and also significant increases of SH groups at multiparous. In the case of pregnant animals that received CoQ10 in antioxidant complexes, we have observed an increase of oxidative stress (OS)-MDA in primiparous and CP in multiparous.
In the case of Vitamin E, taking into account the benefits on redox homeostasis, the decrease of OS, the authors recommend vitamin E administration during pregnancy. However, because of the increase of the OS in the case of pregnant animals, the authors do not recommend the administration of CoQ(10) in antioxidant complexes during pregnancy.</description><identifier>ISSN: 1844-122X</identifier><identifier>EISSN: 1844-3117</identifier><identifier>PMID: 21776299</identifier><language>eng</language><publisher>Romania: Carol Daila University Foundation</publisher><subject>Animals ; Antioxidants - pharmacology ; Female ; Humans ; Hydrogen - blood ; Malondialdehyde - metabolism ; Oxidative Stress - drug effects ; Pregnancy ; Protein Carbonylation - drug effects ; Rats ; Rats, Wistar ; Sulfhydryl Compounds - metabolism ; Ubiquinone - administration & dosage ; Ubiquinone - analogs & derivatives ; Ubiquinone - pharmacology ; Vitamin E - administration & dosage ; Vitamin E - pharmacology</subject><ispartof>Journal of medicine and life, 2011-05, Vol.4 (2), p.163-167</ispartof><rights>Copyright Carol Davila University Foundation Apr-Jun 2011</rights><rights>Carol Davila University Press 2011</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3124270/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3124270/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21776299$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Staicu, M L</creatorcontrib><creatorcontrib>Mureşan, A</creatorcontrib><creatorcontrib>Tache, S</creatorcontrib><creatorcontrib>Moldovan, R</creatorcontrib><title>Effects of exogenous antioxidants on oxidative stress in pregnancy</title><title>Journal of medicine and life</title><addtitle>J Med Life</addtitle><description>The present study evaluated the effects on gestation, in terms of oxidative stress, of two antioxidant factors-vitamin E and coenzyme Q10-during pregnancy, with the purpose of applying the results in further human clinical practice.
For each aspect we have studied, we used three types of female rats of Wistar race (un-pregnant, primiparous, multiparous), divided in 10 rats/group. From the blood we have sampled, we have determined the oxidative stress (OS) markers: malondialdehyde (MDA) and carbonylated proteins (CP), but also the markers of the antioxidant defense: the hydrogen donor capacity of the plasma (HD) and the sulfhydryl groups (SH).
Vitamin E administration determines significant decreases of MDA and significant increases of CP and HD at primiparous, and also significant increases of SH groups at multiparous. In the case of pregnant animals that received CoQ10 in antioxidant complexes, we have observed an increase of oxidative stress (OS)-MDA in primiparous and CP in multiparous.
In the case of Vitamin E, taking into account the benefits on redox homeostasis, the decrease of OS, the authors recommend vitamin E administration during pregnancy. However, because of the increase of the OS in the case of pregnant animals, the authors do not recommend the administration of CoQ(10) in antioxidant complexes during pregnancy.</description><subject>Animals</subject><subject>Antioxidants - pharmacology</subject><subject>Female</subject><subject>Humans</subject><subject>Hydrogen - blood</subject><subject>Malondialdehyde - metabolism</subject><subject>Oxidative Stress - drug effects</subject><subject>Pregnancy</subject><subject>Protein Carbonylation - drug effects</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Sulfhydryl Compounds - metabolism</subject><subject>Ubiquinone - administration & dosage</subject><subject>Ubiquinone - analogs & derivatives</subject><subject>Ubiquinone - pharmacology</subject><subject>Vitamin E - administration & dosage</subject><subject>Vitamin E - pharmacology</subject><issn>1844-122X</issn><issn>1844-3117</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNpVkM1KAzEUhYMottS-ggT3A_mZJJ2NoKVaoeBGwV3IJJma0iZjkint2zvVUfRszoF7-e7lnIExnpVlQTEW50PGhLyNwDSlDepVMs45vQQjgoXgpKrG4H7RNFbnBEMD7SGsrQ9dgspnFw7O9N5PPPzK2e0tTDnalKDzsI127ZXXxytw0ahtstPBJ-D1YfEyXxar58en-d2qaAkSucCsbhTTCpGKCY20oswwbk2t2UxUxmCFuKg5QYphVJtG9UKmUiWtLeUa0Qm4_ea2Xb2zRlufo9rKNrqdikcZlJP_J969y3XYS4pJScQJcDMAYvjobMpyE7ro-5_lTPCKnxrpl67_XvnF_1RGPwEq_WwM</recordid><startdate>20110515</startdate><enddate>20110515</enddate><creator>Staicu, M L</creator><creator>Mureşan, A</creator><creator>Tache, S</creator><creator>Moldovan, R</creator><general>Carol Daila University Foundation</general><general>Carol Davila University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>BYOGL</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>PHGZM</scope><scope>PHGZT</scope><scope>PJZUB</scope><scope>PKEHL</scope><scope>PPXIY</scope><scope>PQEST</scope><scope>PQGLB</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>5PM</scope></search><sort><creationdate>20110515</creationdate><title>Effects of exogenous antioxidants on oxidative stress in pregnancy</title><author>Staicu, M L ; Mureşan, A ; Tache, S ; Moldovan, R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p207t-15bfa5ca02957c0ca35d56edbc5879dd1a067b620a510bdfaaaa0d9a43be36c03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Animals</topic><topic>Antioxidants - pharmacology</topic><topic>Female</topic><topic>Humans</topic><topic>Hydrogen - blood</topic><topic>Malondialdehyde - metabolism</topic><topic>Oxidative Stress - drug effects</topic><topic>Pregnancy</topic><topic>Protein Carbonylation - drug effects</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Sulfhydryl Compounds - metabolism</topic><topic>Ubiquinone - administration & dosage</topic><topic>Ubiquinone - analogs & derivatives</topic><topic>Ubiquinone - pharmacology</topic><topic>Vitamin E - administration & dosage</topic><topic>Vitamin E - pharmacology</topic><toplevel>online_resources</toplevel><creatorcontrib>Staicu, M L</creatorcontrib><creatorcontrib>Mureşan, A</creatorcontrib><creatorcontrib>Tache, S</creatorcontrib><creatorcontrib>Moldovan, R</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection (Proquest)</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>ProQuest Natural Science Collection</collection><collection>East Europe, Central Europe Database</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biological Sciences</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>Biological Science Database</collection><collection>ProQuest Central (New)</collection><collection>ProQuest One Academic (New)</collection><collection>ProQuest Health & Medical Research Collection</collection><collection>ProQuest One Academic Middle East (New)</collection><collection>ProQuest One Health & Nursing</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Applied & Life Sciences</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of medicine and life</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Staicu, M L</au><au>Mureşan, A</au><au>Tache, S</au><au>Moldovan, R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of exogenous antioxidants on oxidative stress in pregnancy</atitle><jtitle>Journal of medicine and life</jtitle><addtitle>J Med Life</addtitle><date>2011-05-15</date><risdate>2011</risdate><volume>4</volume><issue>2</issue><spage>163</spage><epage>167</epage><pages>163-167</pages><issn>1844-122X</issn><eissn>1844-3117</eissn><abstract>The present study evaluated the effects on gestation, in terms of oxidative stress, of two antioxidant factors-vitamin E and coenzyme Q10-during pregnancy, with the purpose of applying the results in further human clinical practice.
For each aspect we have studied, we used three types of female rats of Wistar race (un-pregnant, primiparous, multiparous), divided in 10 rats/group. From the blood we have sampled, we have determined the oxidative stress (OS) markers: malondialdehyde (MDA) and carbonylated proteins (CP), but also the markers of the antioxidant defense: the hydrogen donor capacity of the plasma (HD) and the sulfhydryl groups (SH).
Vitamin E administration determines significant decreases of MDA and significant increases of CP and HD at primiparous, and also significant increases of SH groups at multiparous. In the case of pregnant animals that received CoQ10 in antioxidant complexes, we have observed an increase of oxidative stress (OS)-MDA in primiparous and CP in multiparous.
In the case of Vitamin E, taking into account the benefits on redox homeostasis, the decrease of OS, the authors recommend vitamin E administration during pregnancy. However, because of the increase of the OS in the case of pregnant animals, the authors do not recommend the administration of CoQ(10) in antioxidant complexes during pregnancy.</abstract><cop>Romania</cop><pub>Carol Daila University Foundation</pub><pmid>21776299</pmid><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Antioxidants - pharmacology Female Humans Hydrogen - blood Malondialdehyde - metabolism Oxidative Stress - drug effects Pregnancy Protein Carbonylation - drug effects Rats Rats, Wistar Sulfhydryl Compounds - metabolism Ubiquinone - administration & dosage Ubiquinone - analogs & derivatives Ubiquinone - pharmacology Vitamin E - administration & dosage Vitamin E - pharmacology |
| title | Effects of exogenous antioxidants on oxidative stress in pregnancy |
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