Characterization of the Cysteinyl Leukotriene 2 Receptor in Novel Expression Sites of the Gastrointestinal Tract

Cysteinyl leukotrienes (cysLTs: LTC4 , LTD4 , and LTE4 ) are pro-inflammatory lipid molecules synthesized from arachidonic acid. They exert their actions on at least two cysLT receptors (CysLT1 R and CysLT2 R). Endothelial expression and activation of these receptors is linked to vasoactive response...

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Veröffentlicht in:	The American journal of pathology 2011-06, Vol.178 (6), p.2682-2689
Hauptverfasser:	Barajas-Espinosa, Alma, Ochoa-Cortes, Fernando, Moos, Michael P, Daniel Ramirez, F, Vanner, Stephen J, Funk, Colin D
Format:	Artikel
Sprache:	eng
Schlagworte:	Action Potentials - drug effects Animals Capillary Permeability - drug effects Colitis - complications Colitis - metabolism Colitis - pathology Colon - drug effects Colon - innervation Colon - pathology Colon - physiopathology Cysteine - pharmacology Dextran Sulfate Edema - complications Edema - pathology Edema - physiopathology Extravasation of Diagnostic and Therapeutic Materials Fluorescein-5-isothiocyanate - analogs & derivatives Fluorescein-5-isothiocyanate - metabolism Ganglia, Spinal - drug effects Ganglia, Spinal - metabolism Ganglia, Spinal - pathology Ganglia, Spinal - physiopathology Gastrointestinal Tract - drug effects Gastrointestinal Tract - metabolism Gastrointestinal Tract - pathology Gastrointestinal Tract - physiopathology Intestinal Mucosa - blood supply Intestinal Mucosa - drug effects Intestinal Mucosa - metabolism Intestinal Mucosa - pathology Leukotrienes - pharmacology Mice Mice, Knockout Pathology Receptors, Leukotriene - deficiency Receptors, Leukotriene - metabolism Regular Serum Albumin - metabolism Tumor Necrosis Factor-alpha - biosynthesis Venules - drug effects Venules - metabolism Venules - pathology Venules - physiopathology
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