Targeting ST2L Potentiates CpG-Mediated Therapeutic Effects in a Chronic Fungal Asthma Model

IL-33 and its soluble receptor and cell-associated receptor (ST2L) are all increased in clinical and experimental asthma. The present study addressed the hypothesis that ST2L impairs the therapeutic effects of CpG in a fungal model of asthma. C57BL/6 mice were sensitized to Aspergillus fumigatus and...

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Veröffentlicht in:	The American journal of pathology 2011-07, Vol.179 (1), p.104-115
Hauptverfasser:	Ramaprakash, Hemanth, Shibata, Takehiko, Duffy, Karen E, Ismailoglu, Ugur B, Bredernitz, Rachel M, Moreira, Ana Paula, Coelho, Ana L, Das, Anuk M, Fursov, Natalie, Chupp, Geoffrey L, Hogaboam, Cory M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Monoclonal - therapeutic use Aspergillosis, Allergic Bronchopulmonary - immunology Aspergillosis, Allergic Bronchopulmonary - microbiology Aspergillosis, Allergic Bronchopulmonary - prevention & control Aspergillus fumigatus - immunology Aspergillus fumigatus - metabolism Asthma - microbiology Asthma - prevention & control Biological and medical sciences Blotting, Western Bronchial Hyperreactivity - immunology Bronchial Hyperreactivity - microbiology Bronchial Hyperreactivity - prevention & control Case-Control Studies Chemokine CXCL9 - genetics Chemokine CXCL9 - metabolism Chronic Disease Chronic obstructive pulmonary disease, asthma Disease Models, Animal Enzyme-Linked Immunosorbent Assay Female Fibrosis - prevention & control Humans Immunoenzyme Techniques Immunoglobulin G - therapeutic use Investigative techniques, diagnostic techniques (general aspects) Lung - drug effects Lung - immunology Medical sciences Mice Mice, Inbred C57BL Oligodeoxyribonucleotides - therapeutic use Pathology Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Pneumology Receptors, Interleukin-1 - antagonists & inhibitors Receptors, Interleukin-1 - physiology Regular Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - genetics Toll-Like Receptor 9 - genetics Toll-Like Receptor 9 - metabolism
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