Functional consequences of bidirectional promoters
Several studies have shown that promoters of protein-coding genes are origins of pervasive non-coding RNA transcription and can initiate transcription in both directions. However, only recently have researchers begun to elucidate the functional implications of this bidirectionality and non-coding RN...
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| Veröffentlicht in: | Trends in genetics 2011-07, Vol.27 (7), p.267-276 |
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| container_title | Trends in genetics |
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| creator | Wei, Wu Pelechano, Vicent Järvelin, Aino I Steinmetz, Lars M |
| description | Several studies have shown that promoters of protein-coding genes are origins of pervasive non-coding RNA transcription and can initiate transcription in both directions. However, only recently have researchers begun to elucidate the functional implications of this bidirectionality and non-coding RNA production. Increasing evidence indicates that non-coding transcription at promoters influences the expression of protein-coding genes, revealing a new layer of transcriptional regulation. This regulation acts at multiple levels, from modifying local chromatin to enabling regional signal spreading and more distal regulation. Moreover, the bidirectional activity of a promoter is regulated at multiple points during transcription, giving rise to diverse types of transcripts. |
| doi_str_mv | 10.1016/j.tig.2011.04.002 |
| format | Article |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Animals Biological and medical sciences Fundamental and applied biological sciences. Psychology Gene Expression Regulation Genetics of eukaryotes. Biological and molecular evolution Humans Medical Education Molecular and cellular biology Nucleosomes - genetics Promoter Regions, Genetic RNA, Untranslated - genetics Transcription, Genetic |
| title | Functional consequences of bidirectional promoters |
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