Characterization of Prefibrillar Tau Oligomers in Vitro and in Alzheimer Disease

Neurofibrillary tangles, composed of insoluble aggregates of the microtubule-associated protein Tau, are a pathological hallmark of Alzheimer disease (AD) and other tauopathies. However, recent evidence indicates that neuronal dysfunction precedes the formation of these insoluble fibrillar deposits,...

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Veröffentlicht in:	The Journal of biological chemistry 2011-07, Vol.286 (26), p.23063-23076
Hauptverfasser:	Patterson, Kristina R., Remmers, Christine, Fu, Yifan, Brooker, Sarah, Kanaan, Nicholas M., Vana, Laurel, Ward, Sarah, Reyes, Juan F., Philibert, Keith, Glucksman, Marc J., Binder, Lester I.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer Disease - metabolism Alzheimers Disease Antibodies Arachidonic Acid Biomarkers - chemistry Biomarkers - metabolism Humans Neurobiology Protein Conformation Protein Multimerization Protein Structure, Quaternary Tau tau Proteins - chemistry tau Proteins - genetics tau Proteins - metabolism
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