Autophagosomal IκBα Degradation Plays a Role in the Long Term Control of Tumor Necrosis Factor-α-induced Nuclear Factor-κB (NF-κB) Activity

Transcription factor NF-κB is persistently activated in many chronic inflammatory diseases and cancers. The short term regulation of NF-κB is well understood, but little is known about the mechanisms of its long term activation. We studied the effect of a single application of TNF-α on NF-κB activit...

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Veröffentlicht in:	The Journal of biological chemistry 2011-07, Vol.286 (26), p.22886-22893
Hauptverfasser:	Colleran, Amy, Ryan, Aideen, O'Gorman, Angela, Mureau, Coralie, Liptrot, Catherine, Dockery, Peter, Fearnhead, Howard, Egan, Laurence J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer Disease Cell Death Neurodegeneration Signal Transduction Synapses Tau
Online-Zugang:	Volltext
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