The role of leukocyte-stromal interactions in chronic inflammatory joint disease
Rheumatoid arthritis (RA) is a debilitating, chronic, persistent inflammatory disease that is characterised by painful and swollen joints. The aetiology of RA is unknown, however whereas past research has concentrated on the role of immune or inflammatory infiltrating cells in inflammation, it is be...
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| Veröffentlicht in: | Joint Bone Spine 2005, Vol.72 (1), p.10-16 |
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| creator | Burman, Angela Haworth, Oliver Bradfield, Paul Parsonage, Greg Filer, Andrew Thomas, Andrew M.C. Amft, Nicole Salmon, Mike Buckley, Christopher D. |
| description | Rheumatoid arthritis (RA) is a debilitating, chronic, persistent inflammatory disease that is characterised by painful and swollen joints. The aetiology of RA is unknown, however whereas past research has concentrated on the role of immune or inflammatory infiltrating cells in inflammation, it is becoming clear that stromal cells play a critical part in regulating the quality and duration of an inflammatory response. In this review we assess the role of fibroblasts within the inflamed synovium in modulating immune responses; in particular we examine the role of stromal cells in the switch from resolving to persistent inflammation as is found in the rheumatoid synovium. |
| doi_str_mv | 10.1016/j.jbspin.2004.03.009 |
| format | Article |
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The aetiology of RA is unknown, however whereas past research has concentrated on the role of immune or inflammatory infiltrating cells in inflammation, it is becoming clear that stromal cells play a critical part in regulating the quality and duration of an inflammatory response. 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In this review we assess the role of fibroblasts within the inflamed synovium in modulating immune responses; in particular we examine the role of stromal cells in the switch from resolving to persistent inflammation as is found in the rheumatoid synovium.</description><subject>Animals</subject><subject>Arthritis, Rheumatoid - immunology</subject><subject>Arthritis, Rheumatoid - pathology</subject><subject>Cell Communication - immunology</subject><subject>Chemokines</subject><subject>Chronic Disease</subject><subject>Cytokines</subject><subject>Humans</subject><subject>Inflammation</subject><subject>Leukocytes - cytology</subject><subject>Leukocytes - immunology</subject><subject>Rheumatoid arthritis</subject><subject>Stromal Cells - cytology</subject><subject>Synovitis</subject><subject>Synovitis - immunology</subject><subject>Synovitis - pathology</subject><issn>1297-319X</issn><issn>1778-7254</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9UU1v1DAQtVAR_YB_gFBOvSV47DhOLkioKrRSJTgUiZvlTCasQxIvtrfS_vu62hWlF04zo3nz3sw8xt4Dr4BD83Gqpj5u3VoJzuuKy4rz7hU7A63bUgtVn-RcdLqU0P08ZecxTpxzKVTzhp2CaloQtThj3-83VAQ_U-HHYqbdb4_7RGVMwS92LtyaKFhMzq8xFwVugl8d5nSc7bLY5MO-mHyGFYOLZCO9Za9HO0d6d4wX7MeX6_urm_Lu29fbq893JSoJqVRdj71tuR2w1TQACgSAtu4VyLonIIuku74hpTgOqlakSIydGlstre2VvGCfDrzbXb_QgLSmYGezDW6xYW-8deZlZ3Ub88s_GAlCABeZ4PJIEPyfHcVkFheR5tmu5HfRNFp2oNs2A-sDEIOPMdD4VwS4ebLCTOZghXmywnBpshV57MO_Cz4PHX__fAHlNz04CiaioxVpcIEwmcG7_ys8Av7-n-U</recordid><startdate>2005</startdate><enddate>2005</enddate><creator>Burman, Angela</creator><creator>Haworth, Oliver</creator><creator>Bradfield, Paul</creator><creator>Parsonage, Greg</creator><creator>Filer, Andrew</creator><creator>Thomas, Andrew M.C.</creator><creator>Amft, Nicole</creator><creator>Salmon, Mike</creator><creator>Buckley, Christopher D.</creator><general>Elsevier SAS</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>2005</creationdate><title>The role of leukocyte-stromal interactions in chronic inflammatory joint disease</title><author>Burman, Angela ; 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| ispartof | Joint Bone Spine, 2005, Vol.72 (1), p.10-16 |
| issn | 1297-319X 1778-7254 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Animals Arthritis, Rheumatoid - immunology Arthritis, Rheumatoid - pathology Cell Communication - immunology Chemokines Chronic Disease Cytokines Humans Inflammation Leukocytes - cytology Leukocytes - immunology Rheumatoid arthritis Stromal Cells - cytology Synovitis Synovitis - immunology Synovitis - pathology |
| title | The role of leukocyte-stromal interactions in chronic inflammatory joint disease |
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