Granular expression of prolyl-peptidyl isomerase PIN1 is a constant and specific feature of Alzheimer’s disease pathology and is independent of tau, Aβ and TDP-43 pathology

Alzheimer’s disease (AD) manifests with progressive memory loss and decline of spatial awareness and motor skills. Neurofibrillary tangles (NFTs) represent one of the pathological hallmarks of AD. Previous studies suggest that the enzyme prolyl-peptidyl cis – trans isomerase PIN1 [protein interactin...

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Veröffentlicht in:	Acta neuropathologica 2011-05, Vol.121 (5), p.635-649
Hauptverfasser:	Dakson, Ayoub, Yokota, Osamu, Esiri, Margaret, Bigio, Eileen H., Horan, Michael, Pendleton, Neil, Richardson, Anna, Neary, David, Snowden, Julie S., Robinson, Andrew, Davidson, Yvonne S., Mann, David M. A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Alzheimer Disease - diagnosis Alzheimer Disease - enzymology Alzheimer Disease - pathology Amyloid beta-Peptides - metabolism Biomarkers - metabolism Cytoplasmic Granules - enzymology Cytoplasmic Granules - pathology DNA-Binding Proteins - metabolism Female Humans Inclusion Bodies - enzymology Inclusion Bodies - pathology Male Medicine Medicine & Public Health Middle Aged Neurosciences NIMA-Interacting Peptidylprolyl Isomerase Original Paper Pathology Peptidylprolyl Isomerase - biosynthesis Peptidylprolyl Isomerase - genetics Peptidylprolyl Isomerase - metabolism tau Proteins - metabolism
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