Prdm14 initiates lymphoblastic leukemia after expanding a population of cells resembling common lymphoid progenitors

Understanding the heterogeneous genetic mechanisms of tumor initiation in lymphoid leukemias (LL) will lead to improvements in prognostic classification and treatment regimens. In previous studies of mouse leukemias, we showed that retroviral insertion at the ecotropic viral insertion site 32 locus...

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Veröffentlicht in:	Oncogene 2011-06, Vol.30 (25), p.2859-2873
Hauptverfasser:	Dettman, E J, Simko, S J, Ayanga, B, Carofino, B L, Margolin, J F, Morse, H C, Justice, M J
Format:	Artikel
Sprache:	eng
Schlagworte:	692/420/2489/68 692/699/67/1990/283 Acute lymphocytic leukemia Animals Apoptosis Biological and medical sciences Bone marrow Breast cancer Cancer Cell Biology Cell differentiation Cell physiology Cell self-renewal Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes Cells DNA microarrays DNA-Binding Proteins Embryo cells Embryonic stem cells Estrogens Female Fundamental and applied biological sciences. Psychology Gene expression Genetic aspects Genetic Predisposition to Disease Genetics Hematologic and hematopoietic diseases Human Genetics Insertion Internal Medicine Leukemia Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Lymphatic leukemia Lymphocytes Lymphocytes B Lymphocytes T Male Medical sciences Medicine Medicine & Public Health Mesenchyme Mice Molecular and cellular biology Oncology original-article Pluripotency Polymerase chain reaction Preadipocyte factor 1 Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics Precursor Cell Lymphoblastic Leukemia-Lymphoma - pathology Progenitor cells RNA-Binding Proteins Stem cell transplantation Stem cells Transcription Factors - genetics Transcription Factors - physiology Tumors Wnt protein
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