Pathogenesis of Renal Injury in the Megabladder Mouse: A Genetic Model of Congenital Obstructive Nephropathy

Congenital obstructive nephropathy (CON) is the most common cause of chronic renal failure in children often leading to end-stage renal disease. The megabladder ( mgb ) mouse exhibits signs of urinary tract obstruction in utero resulting in the development of hydroureteronephrosis and progressive re...

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Veröffentlicht in:	Pediatric research 2010-12, Vol.68 (6), p.500-507
Hauptverfasser:	Ingraham, Susan E, Saha, Monalee, Carpenter, Ashley R, Robinson, Melissa, Ismail, Ihab, Singh, Sunita, Hains, David, Robinson, Michael L, Hirselj, Daniel A, Koff, Stephen A, Bates, Carlton M, McHugh, Kirk M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals basic-science-investigation Biological and medical sciences Child Cystostomy Disease Models, Animal Disease Progression Fibrosis General aspects Humans Hydronephrosis - complications Hydronephrosis - congenital Hydronephrosis - pathology Hydronephrosis - surgery Kidney - diagnostic imaging Kidney - injuries Kidney - pathology Kidney Failure, Chronic - congenital Kidney Failure, Chronic - etiology Kidney Failure, Chronic - pathology Kidney Failure, Chronic - surgery Kidneys Male Medical sciences Medicine Medicine & Public Health Mice Mice, Knockout Mice, Mutant Strains Nephritis, Interstitial - complications Nephritis, Interstitial - congenital Nephritis, Interstitial - pathology Nephritis, Interstitial - surgery Nephrology. Urinary tract diseases Pediatric Surgery Pediatrics Ultrasonography Urinary system involvement in other diseases. Miscellaneous Urinary tract. Prostate gland
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