Numerical classification of coding sequences
DNA sequences coding for protein may be represented by counts of nucleotides or codons. A complete reading frame may be abbreviated by its base count, e.g. A76C158G121T74, or with the corresponding codon table, e.g. (AAA)0(AAC)1(AAG)G ...(TTT)0. We propose that these numerical designations be used t...
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| Veröffentlicht in: | Nucleic acids research 1992-03, Vol.20 (6), p.1405-1410 |
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| container_title | Nucleic acids research |
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| creator | Collins, D.W Liu, C.C Jukes, T.H |
| description | DNA sequences coding for protein may be represented by counts of nucleotides or codons. A complete reading frame may be abbreviated by its base count, e.g. A76C158G121T74, or with the corresponding codon table, e.g. (AAA)0(AAC)1(AAG)G ...(TTT)0. We propose that these numerical designations be used to augment current methods of sequence annotation. Because base counts and codon tables do not require revision as knowledge of function evolves, they are well-suited to act as cross-references, for example to identify redundant GenBank entries. These descriptors may be compared, in place of DNA sequences, to extract homologous genes from large databases. This approach permits rapid searching with good selectivity. |
| doi_str_mv | 10.1093/nar/20.6.1405 |
| format | Article |
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A complete reading frame may be abbreviated by its base count, e.g. A76C158G121T74, or with the corresponding codon table, e.g. (AAA)0(AAC)1(AAG)G ...(TTT)0. We propose that these numerical designations be used to augment current methods of sequence annotation. Because base counts and codon tables do not require revision as knowledge of function evolves, they are well-suited to act as cross-references, for example to identify redundant GenBank entries. These descriptors may be compared, in place of DNA sequences, to extract homologous genes from large databases. 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| ispartof | Nucleic acids research, 1992-03, Vol.20 (6), p.1405-1410 |
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| language | eng |
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| source | MEDLINE; Oxford University Press Journals Digital Archive Legacy; NASA Technical Reports Server; PubMed Central |
| subjects | Animals Codon Databases, Factual DNA dna sequence annotations Exobiology Exons Genetic Techniques Humans indexing information processing nucleotide sequences Space life sciences |
| title | Numerical classification of coding sequences |
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