Phosphorylation and Mutation of Phospholamban Alter Physical Interactions With the Sarcoplasmic Reticulum Calcium Pump

Phospholamban physically interacts with the sarcoplasmic reticulum calcium pump (SERCA) and regulates contractility of the heart in response to adrenergic stimuli. We studied this interaction using electron microscopy of 2D crystals of SERCA in complex with phospholamban. In earlier studies, phospho...

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Veröffentlicht in:	Journal of molecular biology 2011-01, Vol.405 (3), p.707-723
Hauptverfasser:	Glaves, John Paul, Trieber, Catharine A., Ceholski, Delaine K., Stokes, David L., Young, Howard S.
Format:	Artikel
Sprache:	eng
Schlagworte:	2D crystals Amino Acid Sequence Animals Ca2-transporting ATPase Calcium-Binding Proteins - chemistry Calcium-Binding Proteins - genetics Calcium-Binding Proteins - metabolism crystals data collection electron crystallography electron microscopy heart Humans Models, Molecular Molecular Sequence Data mutants Mutation phospholamban Phosphorylation Protein Binding Protein Conformation Rabbits sarcoplasmic reticulum Sarcoplasmic Reticulum - metabolism Sarcoplasmic Reticulum Calcium-Transporting ATPases - chemistry Sarcoplasmic Reticulum Calcium-Transporting ATPases - metabolism SERCA
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