Structure of the Membrane-tethering GRASP Domain Reveals a Unique PDZ Ligand Interaction That Mediates Golgi Biogenesis

Biogenesis of the ribbon-like membrane network of the mammalian Golgi requires membrane tethering by the conserved GRASP domain in GRASP65 and GRASP55, yet the tethering mechanism is not fully understood. Here, we report the crystal structure of the GRASP55 GRASP domain, which revealed an unusual ar...

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Veröffentlicht in:	The Journal of biological chemistry 2011-06, Vol.286 (23), p.20125-20129
Hauptverfasser:	Truschel, Steven T., Sengupta, Debrup, Foote, Adam, Heroux, Annie, Macbeth, Mark R., Linstedt, Adam D.
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES BASIC BIOLOGICAL SCIENCES CRYSTAL STRUCTURE Crystallography, X-Ray FUNCTIONALS Golgi Golgi Apparatus - chemistry Golgi Apparatus - genetics Golgi Apparatus - metabolism Golgi Matrix Proteins HeLa Cells Humans Intracellular Membranes - chemistry Intracellular Membranes - metabolism Membrane Biogenesis Membrane Fusion MEMBRANE PROTEINS Membrane Proteins - chemistry Membrane Proteins - genetics Membrane Proteins - metabolism Membrane Trafficking MEMBRANES PDZ Domains Protein Folding PROTEIN STRUCTURE SPECIFICITY
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